ʻO nā pēpē a me nā keiki 9 mahina a hiki i 4 mau makahiki me ka meaʻai iron-deficiency anemia i ʻoi aku ka nui o ka hoʻonui ʻana i ka neʻe ʻana o ka hemoglobin me ka ferrous sulfate ma mua o ka hao-polysaccharide complexes i nā wiki he 12, e like me ka hoʻokolohua hoʻokolohua randomized i paʻi ʻia ma JAMA.Nui.
ʻO ka anemia nele i ka hao i nā kamaliʻi a me nā keiki liʻiliʻi - ka mea maʻamau ma muli o ka ʻai nui ʻana i ka waiū bipi a i ʻole ka hānai lōʻihi ʻana me ka hoʻohui ʻole ʻana i ka hao - ua hoʻopilikia ʻia ma mua o 1 biliona kānaka ma ka honua holoʻokoʻa i ka makahiki 2010, 3% o lākou he mau keiki 1 a 2 mau makahiki ma ʻAmelika. .He mea maʻamau ia i nā keiki ulu wikiwiki a hiki ke hoʻoulu i ka huhū, ka malaise, ka pica, a me nā maʻi neurodevelopmental pōkole a lōʻihi.
Ferrous sulfate, he paʻakai hao, ʻo ia ka lāʻau lapaʻau maʻamau no ka anemia hemahema hao.
"He mea maʻamau ka hana ʻole ʻana ma muli o ka mālama ʻole ʻana i ka lāʻau lapaʻau, nā hopena ʻino e pili ana i ka overdose, a me ka nele o nā alakaʻi alakaʻi e pili ana i nā hōʻikeʻike," wahi a Jacquelyn M. Powers, MD, MS, School of Medicine, Baylor Assistant Professor of Pediatrics and Hematology Ua kākau ʻo Oncology, a me nā hoa hana.
Ua loiloi nā mana a me nā hoa hana i ka hao-polysaccharide complexes i loko o 80 pēpē a me nā keiki 9 a 48 mahina (median makahiki, 22 mahina; 55% kāne; 61% keʻokeʻo Hispanic) me ka meaʻai iron deficiency anemia Ua ʻoi aku ka maikaʻi ma mua oferrous sulfatee hoʻonui i ka pae hemoglobin.
Ma waena o Kepakemapa 2013 a me Nowemapa 2015, ua hoʻokaʻawale nā mea noiʻi i nā keiki e loaʻa i ka 3 mg / kg o ka hao elemental i kēlā me kēia lā e like me ka hāʻule ʻana o ka sulfate ferrous (n = 40) a i ʻole nā hāʻule o ka iron-polysaccharide complex (n = 40) = 40) no 12 pule. .
Ua aʻo ʻia nā mākua a i ʻole nā mea mālama e hāʻawi i ka lāʻau i kēlā me kēia lā i ka wā e moe ai, e pale i ka hui ʻana i ka ʻai me kekahi meaʻai a mea inu paha, a e pale i ka waiū no 1 hola ma hope o ka hoʻohana ʻana i ka lāʻau noiʻi. ka nui o 600ml i kēlā me kēia lā.
ʻO ka hoʻololi ʻana i ka hemoglobin i nā pule he 12 i lawelawe ʻia ma ke ʻano he hopena mua. ʻO nā hopena hope loa i komo i ka hoʻonā piha ʻana o ka anemia deficiency hao, nā loli i nā pae ferritin serum a me ka nui o ka mana paʻa hao, a me nā hopena ʻino.
He kanalimakūmāiwa mau mea komo i hoʻopau i ka hoʻokolokolo, 28 mai ka hui ferrous sulfate a me 31 mai ka hui paʻakikī iron-polysaccharide.
Mai ka papa kuhikuhi a hiki i ka pule 12, ua hoʻonui ʻia ka hemoglobin mai 7.9 g/dL a i 11.9 g/dL i ka hui ferrous sulfate a mai 7.7 g/dL a i 11.1 g/dL i ka hui hao-polysaccharide complex, ʻoi aku ka ʻokoʻa o 1 g / dL (95% CI, 0.4-1.6; P <.001) me ka ferrous sulfate.
Ke hoʻohālikelikeʻia me ka hui polysaccharide hao,ʻo nā kamaliʻi a me nā keiki i loko o ka hui ferrous sulfate he kiʻekiʻe aʻe o ka hoʻopau pihaʻana o ka anemia hemahema hao (29% vs 6%; P = .04) . 15.6 ng/mL i ka hui ferrous sulfate a mai ka 2 ng/mL a i ka 7.5 ng/mL i ka hui hao-polysaccharide paʻakikī, me ka ʻokoʻa nui o 10.2 ng/mL (95 ng/mL).% CI, 6.2-14.1;P <.001) me ka ferrous sulfate.
Ua emi mai ka nui o ka mana hoʻopaʻa hao mai 501 µg/dL a i 389 µg/dL, a ua emi iho ka ferrous sulfate mai 506 µg/dL a i 417 µg/dL, a ʻo ka hao-polysaccharide complex he –50 µg/dL (95% , -86 a i -14; P <.001) a me ka ferrous sulfate.
ʻOi aku ka maʻamau o ka maʻi maʻi me ka hao-polysaccharide complexes ma mua o ka ferrous sulfate (58% vs 35%; P = .04).
Ua ʻike nā mea noiʻi he 50 pakeneka o nā mākua a me nā mea mālama i hōʻike i ka paʻakikī o ka lawelawe ʻana i ka paʻakikī iron-polysaccharide, i hoʻohālikelike ʻia me 65 pakeneka o ka hui ferrous sulfate.
ʻO nā palena o ke aʻo ʻana, ua mālama ʻia ia ma kahi halemai keiki mālama kula kiʻekiʻe a loaʻa ka hapa like ʻole o ka poʻe maʻi haʻahaʻa a me nā mea liʻiliʻi me ka anemia koʻikoʻi, ma kahi o 23% o lākou i koi ʻia i ke kahe koko ma mua o ke kākau inoa ʻana.
"Pono kēia mau hopena e kōkua i ka hoʻāʻo hou ʻana i nā lāʻau lapaʻau e loiloi i ka haʻahaʻa a i ʻole ka liʻiliʻi pinepine o ka hao waha," i kākau ai ʻo Powers a me nā hoa hana.– ʻO Chuck Gormley
Hōʻike: Na Gensavis Pharmaceuticals i kākoʻo i kēia haʻawina. ʻAʻole hōʻike nā mea noiʻi i nā hōʻike kālā pili.
Ka manawa hoʻouna: Mar-21-2022