Indications
This product is suitable for Streptococcus (except Enterococcus), Pneumococcus, Neisseria gonorrhoeae, Staphylococcus catarrhalis, Escherichia coli, Klebsiella, and Serratia that are sensitive to cefixime , Proteus, influenza bacillus, etc. caused by the following infections are effective. Acute attack of chronic bronchitis, acute bronchitis with bacterial infection, bronchiectasis with infection, pneumonia, pyelonephritis, cystitis, gonococcal urethritis, acute biliary system bacterial infection (cholecystitis, cholangitis) scarlet fever ; Otitis media, sinusitis.
Pharmacological action
1 Pharmacological action: This product is a broad-spectrum antibiotic, which has antibacterial activity against some Gram-positive bacteria and negative bacteria, especially Streptococcus (except Enterococcus) and Pneumococcus among Gram-positive bacteria. , Neisseria gonorrhoeae, Branhamella, Escherichia coli, Klebsiella, Serratia, Proteus, influenza bacilli, etc. among Gram-negative bacteria have strong antibacterial effects, and their mechanism of action is bactericidal sexual. This product has strong stability to β-lactamase produced by various bacteria, and shows superior antibacterial effect on β-lactamase-producing bacteria. The mechanism of action of this product is to prevent the synthesis of bacterial cell walls, and its action point varies with the bacterial species. It has high affinity with 1 (la, lb, 1c) and 3 of penicillin-binding protein (PBP). 2 Toxicology study (1) Acute toxicity (LD50mg/kg) (2) Subacute and chronic toxicity Oral administration of 100, 320 and 1,000 mg/kg for adult SD rats for 13 weeks, and 100, 200 and 400 mg for adult dogs /kg orally administered for 5 weeks, all experiments found no abnormalities. Orally administered to immature SD rats (aged 4 days) for 22 days, spermatocytes were found to decrease in the dose group above 10,000 mg/kg, and weight gain accompanied by a decrease in testis weight was found in the dose group of 3,200 mg/kg Inhibition, but the above-mentioned situation was not found in the experiment of 3,200mg/kg orally administered to immature rats at 21 days of development for 5 weeks and 100, 200, 400mg/kg orally administered to immature dogs for 5 weeks. In the experiment of oral administration of 100, 320 and 1,000 mg/kg to adult SD rats for 53 weeks, changing the dosage found that the weight gain of female rats given 1000 mg/kg was inhibited, and the urine protein of male rats was inhibited. amount increased. Increased kidney weight and chronic kidney disease were enhanced. (3) Effects on the reproductive system Oral administration of 100-1,000 mg/kg before pregnancy and early pregnancy in SD rats, and 320-3,200 mg/kg in the period of organogenesis, perinatal period and lactation period Its influence on the reproductive system was not found to affect the reproductive ability and teratogenicity of rats, and no abnormalities were found in the growth, development and reproductive ability of newborn mice. 3 Effects on the kidneys: Give rabbits 1000mgkg of the drug orally at a time, observe its effects on the kidneys, and find no abnormalities. Oral administration of 560 mg/kg to SD rats combined with diuretics did not cause any abnormalities after medication for 2 consecutive weeks, nor did there appear to be any deterioration of renal function caused by diuretics. 4 Antigenicity The antigenicity of this drug to various animals is the same as or slightly weaker than that of cephalexin. The drug does not induce antigenicity, nor is it immunologically cross-reactive with cephalexin, cefaclor and ceftiazoxime.
Post time: Jan-09-2023