Chloramphenicol sodium succinatefari ne ko rawaya-fari hygroscopic foda.1.4 g na abu guda ɗaya yana kusan daidai da 1 g na chloramphenicol.
Rigakafi
Chtoramphenicot an hana shi a cikin marasa lafiya da ke da tarihin hauhawar jini ko amsa mai guba ga miyagun ƙwayoyi.Kada a taɓa ba shi tsarin tsarin don ƙananan cututtuka ko don rigakafi.gudanarwa lokaci guda na chtoramphenicot tare da wasu magungunan da za a iya rage kumburin kasusuwa ya kamata a guji.Ya kamata a ba da rangwamen rufewa ga marasa lafiya da rashin aikin hanta.Chloramhemcol na iya tsoma baki tare da haɓakar rigakafi kuma bai kamata a ba shi yayin rigakafin aiki ba.
Mu'amala
Chloramphenicol yana aiki a cikin hanta kuma yana iya, sabili da haka, yin hulɗa tare da magungunan da ke daidaitawa ta hanyar hanta microsomal enzymes.Misali, chloramphenicol yana inganta tasirin coumarm anticoagulants kamar dicoumarol da warfarin sodium, wasu hypoglycemic irin su chlorpropamide da tolbutamide, da magungunan kashe kwayoyin cuta irin su phenytoin, kuma yana iya rage metabolism na cuctophosphamufe zuwa yanayin aikinsa.Sabanin haka, ana iya lalata metabolism na chloramphemcol ta hanyar masu sarrafa enzymes na hanta kamar phenobarbitone ko nfampicin.An ba da rahoton sakamako masu karo da juna tare da paracetamol da phenytoin.Chloramphenicol na iya rage tasirin baƙin ƙarfe da bitamin Bi2 a cikin marasa lafiya masu fama da rashin ƙarfi kuma yana lalata aikin maganin hana haihuwa.
Ayyukan Antimicrobial
Chloramphe.nicol ne g bacteriostatic kwayoyin cuta witi fadi da kewayon mataki a kan duka Gram-positive da Gram-korau kwayoyin cuta, da kuma wasu sauran kwayoyin.
Amfani da Gudanarwa
V Alhaki, na chloranphenicol zuwa tsokanar illa mai barazanar rayuwa, musamman aplasia-lare-layi,.ya iyakance amfaninsa na asibiti sosai, kodayake har yanzu ana amfani da shi sosai a wasu ƙasashe.Bai kamata ya zama giyen ba a tsarin, don ƙananan cututtuka da ƙididdigar jini na yau da kullum yawanci yana da kyau a lokacin jiyya.Cefalosporins na ƙarni na uku yanzu ana fifita su don yawancin tsoffin alamun chlorampheniclo.A sakamakon haka, akwai 'yan alamomi marasa ma'ana don amfani da chloramphenicol.An yi amfani da shi a cikin mummunar cutar taifot da sauran cututtuka na salmonella, ko da yake baya kawar da halin da ake ciki.Chloramphenicol shine madadin cephalosporin na ƙarni na uku a cikin maganin cutar sankarau na kwayan cuta, duka a cikin epirically da kuma ga ƙwayoyin cuta kamar Haemophtlus tnfluenzae.An yi amfani da shi wajen maganin cututtuka masu tsanani na anaerobic, patricularly a cikin ƙananan ƙwayoyin kwakwalwa, da kuma cututtuka da ke ƙasa da diaphragm inda Bacteroides fragitis yakan haifar da shi;duk da haka, ana fi son sauran kwayoyi.Ko da yake tetracyclines sun kasance maganin da za a zabi a cikin cututtuka na rickettsial kamar typhus da s, zazzaɓi, chforamphenicol kuma ana amfani dashi azaman madadin inda tetracyclines, ba za a iya ba.
Sauran cututtuka na kwayan cuta da za a iya amfani da chloramphenicol a matsayin madadin wasu magunguna sun haɗa da anthrax, cututtuka masu tsanani tare da tayin Campylobacter, ehrlichiosis, gastro-ententis mai tsanani, , gas gangrene, granuloma inguinale, cututtuka masu tsanani na Haemophilus influenzae banda meningitis (misali a cikin ciki). epiglottitis), listeriosis, metioidosis mai tsanani, annoba (musamman idan sankarau ya tasowa), psittacosis, tularaemia (musamman[y lokacin da ake zargin sankarau), da cutar Whipple.Don cikakkun bayanai game da waɗannan cututtukan da maganin su..
Ana amfani da Chioramphenicol sosai a cikin jiyya na waje, na kunne da kuma, m musamman, mfections ido, duk da cewa yawancin waɗannan suna da sauƙi kuma suna da kansu.Hakanan ana amfani da shi a kai a kai m maganin cututtukan skm.Ana bayyana allurai m sharuddan tushen chloramphenicol kuma suna kama da ko ana gudanar da su ta baki ko ta hanyar jijiya.Ga manya da yara, kashi na yau da kullun shine 5O MG a kowace kilogiram na nauyin jiki kowace rana a cikin raba allurai kowane sa'o'i 6;har zuwa 100 MG a kowace kilogiram kowace rana ana iya ba da ciwon sankarau ko cututtuka masu tsanani saboda kwayoyin halitta masu juriya masu matsakaici, ko da yake ya kamata a rage yawan allurai da wuri-wuri.Don rage nsk na sake dawowa an ba da shawarar cewa a ci gaba da magani bayan yanayin zafi na majiyyaci ya dawo daidai don ƙarin kwanaki 4 m cututtuka na nckettsial kuma na kwanaki 8 zuwa 10 a cikin lever na typhoid.
Inda babu wani madadin yin amfani da çhloramphenicol, wanda bai kai ba da kuma cikakken tern, ana iya ba da jarirai na yau da kullun na 25 MG kowace kilogiram na nauyin jiki da cikakken jarirai sama da shekaru 2 makonni, ana iya ba su har zuwa 50 MG. a kowace kilogiram na yau da kullun, m 4 raba allurai: Motar da adadin plasma yana da mahimmanci don, guje wa guba.
A cikin marasa lafiya da ke da rauni na aikin he.patic ko mai tsanani na renal inipainent, adadin chloramphenicol na iya buƙatar sakewa saboda raguwar cimelabolism ko fitarwa.
A cikin kula da mfections ido chloramphenicol yawanci ana amfani dashi azaman 0.5% bayani ko azaman maganin shafawa na 1%.
Mummunan Tasiri
Chloramhemcol na iya haifar da mummunan tasiri kuma wani lokacin m.Wasu daga cikin gubarsa ana tsammanin suna da tasiri akan haɗakar furotin mitochondnal.Mafi munin illar chloramhemcol shine baƙin ciki na bargon ƙashi, wanda zai iya ɗaukar nau'ikan nau'ikan 2 daban-daban.Na farko shine yanayin juzu'i mai jujjuyawa na gama gari wanda ke faruwa yawanci lokacin da adadin plasma-chloramphenicol ya wuce 25 ug permL kuma yana da alaƙa da yanayin yanayin yanayin ƙasusuwan kasusuwa, rage amfani da ƙarfe, reticulocylopenia anemia, leucopenia da thrombocytopenia.Wannan sakamako na iya zama saboda hana haɗin gina jiki a cikin mitochomária na ƙwayoyin kasusuwa na kasusuwa.Anaphylaxis ya faru amma yana da wuya, halayen Jansch-Herxheimer na iya faruwa.Alamomin ciki ciki har da tashin zuciya, amai, da gudawa na iya biyo bayan gudanar da baki.Rushewar flora na baka da na hanji, na iya haifar da stomatitis, glossitis, da kumburin hanji, marasa lafiya na iya samun ɗanɗano mai ɗaci bayan saurin sarrafa chloramphenicot sodium succinate.
Yawan wuce gona da iri
An gano ciwon hanta na gawayi ya fi musanya ƙarin jini a cikin ɓangarorin nau'in chloramphenicol, duk da cewa ya hana mutuwar ɗan mako 7 da ciwon toka mai launin toka biyo bayan kuskuren crosage.
Lokacin Shelf:
Shekara uku
