Jarirai da yara 'yan watanni 9 zuwa 4 masu shekaru tare da ƙarancin ƙarancin ƙarfe na abinci mai gina jiki sun sami ƙaruwa mafi girma a cikin haemoglobin tare da ferrous sulfate fiye da rukunin ƙarfe-polysaccharide a cikin makonni 12, bisa ga gwajin gwaji na asibiti da aka buga a JAMA.Babban.
Rashin ƙarancin ƙarfe a cikin jarirai da yara ƙanana - wanda aka fi sani da yawan shan nonon saniya ko tsawaita shayarwa ba tare da ingantaccen ƙarfe ba - ya shafi mutane fiye da biliyan 1 a duniya a cikin 2010, 3% daga cikinsu yara ne masu shekaru 1 zuwa 2 a Amurka. .Yawanci yana faruwa a cikin yara masu girma da sauri kuma yana iya haifar da rashin jin daɗi, rashin jin daɗi, pica, da gajere da kuma dogon lokaci na rashin lafiyar neurodevelopment.
Ferrous sulfate, Gishiri na baƙin ƙarfe, shine ma'auni na maganin rashin abinci mai gina jiki-rashin anemia. Duk da haka, wani hadadden ƙarfe-polysaccharide wanda ke dauke da ferric iron (NovaFerrum, Gensavis Pharmaceuticals) za a iya amfani dashi azaman madadin saboda yana iya inganta haƙuri da dandano.
"Rashin jiyya ya kasance na kowa saboda rashin bin magani, mummunan tasirin da ke tattare da wuce gona da iri, da kuma rashin ka'idodin gudanarwa na tushen shaida," in ji Jacquelyn M. Powers, MD, MS, Makarantar Medicine, Baylor Mataimakin Farfesa na Pediatrics da Hematology. / Oncology, da abokan aiki sun rubuta.''Yan gwaje-gwaje na asibiti da bazuwar bazuwar sun ba da sanarwar zaɓin ƙirar ƙarfe, tsarin allurai, da tsawon lokacin jiyya, ba tare da la'akari da asalin ilimin ilimin ilimin halitta, shekaru, ko jima'i na mutanen da abin ya shafa ba."
Mahukunta da abokan aiki sun kimanta rukunin ƙarfe-polysaccharide a cikin jarirai 80 da yara 9 zuwa watanni 9 zuwa 48 (tsakanin shekaru, watanni 22; 55% namiji; 61% farin Hispanic) tare da ƙarancin ƙarfe na baƙin ƙarfe anemia Shin yana da inganci fiye daferrous sulfatedon ƙara haemoglobin taro.
Tsakanin Satumba 2013 da Nuwamba 2015, masu bincike sun ba da izini ga yara don karɓar 3 mg / kg na ƙarfe na ƙarfe sau ɗaya kowace rana kamar yadda ferrous sulfate drops (n = 40) ko iron-polysaccharide complex drops (n = 40) = 40) na makonni 12. .
An umurci iyaye ko masu kulawa da su gudanar da maganin yau da kullum a lokacin kwanta barci, don kauce wa haɗuwa da kashi tare da kowane abinci ko abin sha, da kuma guje wa madara na tsawon sa'a 1 bayan gudanar da maganin binciken. matsakaicin 600 ml kowace rana.
Canje-canje a cikin haemoglobin a cikin makonni 12 ya kasance a matsayin matsayi na farko. Ƙarshen na biyu ya haɗa da cikakken ƙuduri na anemia rashi na baƙin ƙarfe, canje-canje a cikin matakan ferritin na jini da jimlar ƙarfin ƙarfe na ƙarfe, da kuma mummunan tasiri.
Mahalarta hamsin da tara sun kammala gwajin, 28 daga rukunin ferrous sulfate da 31 daga rukunin hadaddun ƙarfe-polysaccharide.
Daga asali zuwa mako na 12, ma'anar haemoglobin ya karu daga 7.9 g / dL zuwa 11.9 g / dL a cikin rukunin sulfate na ferrous kuma daga 7.7 g / dL zuwa 11.1 g / dL a cikin rukunin hadaddun baƙin ƙarfe-polysaccharide, babban bambanci na 1 g / dL (95% CI, 0.4-1.6; P <.001) tare da ferrous sulfate.
Idan aka kwatanta da ƙungiyar polysaccharide na baƙin ƙarfe, jarirai da yara a cikin rukuni na sulfate na ferrous suna da mafi girma yawan adadin anemia na rashin ƙarfi na baƙin ƙarfe (29% vs 6%; P = .04) .Matsakaicin matsakaicin ƙwayar ferritin ya karu daga 3 ng / mL zuwa 15.6 ng / ml a cikin rukuni na sulfate na ferrous kuma daga 2 ng / ml zuwa 7.5 ng / mL a cikin rukuni na baƙin ƙarfe-polysaccharide, tare da babban bambanci na 10.2 ng / ml (95 ng / ml).% CI, 6.2-14.1;P <.001) tare da ferrous sulfate.
Matsakaicin jimlar ƙarfin ɗaurin ƙarfe ya ragu daga 501 μg/dL zuwa 389 μg/dL, yayin da ferrous sulfate ya ragu daga 506 μg/dL zuwa 417 μg/dL, kuma hadadden ƙarfe-polysaccharide shine –50 μg/dL (95% CI). , -86 zuwa -14; P <.001) da kuma ferrous sulfate.
Zawo ya fi kowa tare da rukunin ƙarfe-polysaccharide fiye da tare da sulfate na ƙarfe (58% vs 35%; P = .04).
Masu binciken sun lura cewa kashi 50 cikin 100 na iyaye da masu kulawa sun ba da rahoton wahalar gudanar da hadadden ƙarfe-polysaccharide, idan aka kwatanta da kashi 65 na rukunin sulfate na ferrous.
Iyakokin binciken sun haɗa da cewa an gudanar da shi a asibitin kula da manyan makarantu na yara kuma yana da ƙayyadaddun kaso na masu karamin karfi da marasa lafiya marasa lafiya da ke fama da cutar anemia mai tsanani, kusan kashi 23% daga cikinsu suna buƙatar ƙarin jini kafin yin rajista.
"Waɗannan sakamakon ya kamata su taimaka ƙara ƙarin gwaje-gwaje na asibiti don kimanta ƙananan ko žasa da yawa na baƙin ƙarfe na baki," Powers da abokan aiki sun rubuta." Sakamakon da ake tsammanin zai iya haɗawa da ingantacciyar yarda da haƙuri da haɓakar ƙwayar ƙarfe, wanda ya haifar da mafi kyawun amsawar jini."- Chuck Gormley
Bayyanawa: Kamfanin Gensavis Pharmaceuticals ya tallafa wa wannan binciken. Masu binciken ba su bayar da rahoton wani bayanin kuɗi da ya dace ba.
Lokacin aikawa: Maris 21-2022