Cov me nyuam mos thiab cov me nyuam hnub nyoog 9 hli mus rau 4 xyoos nrog kev noj zaub mov tsis muaj hlau tsis txaus ntshav ntshav muaj qhov nce ntxiv hauv hemoglobin concentration nrog ferrous sulfate ntau dua li cov hlau-polysaccharide complexes ntawm 12 lub lis piam, raws li kev soj ntsuam randomized luam tawm hauv JAMA.Loj.
Iron-deficiency anemia nyob rau hauv cov menyuam mos thiab cov menyuam yaus - feem ntau tshwm sim los ntawm kev noj cov nyuj ntau dhau los yog kev pub niam mis ntev uas tsis muaj hlau ntxiv - cuam tshuam ntau dua 1 billion tus neeg thoob ntiaj teb hauv xyoo 2010, 3% ntawm lawv muaj hnub nyoog 1 txog 2 xyoos Cov menyuam yaus hauv Asmeskas .Nws feem ntau tshwm sim hauv cov menyuam yaus uas loj hlob sai thiab tuaj yeem ua rau muaj kev ntxhov siab, ua tsis taus pa, pica, thiab cov kab mob neurodevelopmental nyob rau lub sijhawm luv.
Ferrous sulfate, hlau ntsev, yog cov qauv kev kho mob rau cov zaub mov tsis muaj hlau tsis txaus anemia.Txawm li cas los xij, cov hlau-polysaccharide complex uas muaj ferric hlau (NovaFerrum, Gensavis Pharmaceuticals) tuaj yeem siv los ua lwm txoj hauv kev vim nws tuaj yeem txhim kho kev siab ntev thiab saj.
Jacquelyn M. Powers, MD, MS, Tsev Kawm Ntawv Tshuaj, Baylor Assistant xibfwb ntawm Pediatrics thiab Hematology hais tias / Oncology, thiab cov npoj yaig tau sau tseg. "Kev sim kuaj ob peb lub hlis dhau los qhia txog kev xaiv cov qauv hlau, kev siv tshuaj, thiab lub sijhawm ntawm kev kho mob, tsis hais txog lub hauv paus etiology, hnub nyoog, lossis poj niam txiv neej ntawm cov neeg cuam tshuam."
Lub hwj chim thiab cov npoj yaig tau soj ntsuam cov hlau-polysaccharide complexes hauv 80 tus menyuam mos thiab cov menyuam yaus hnub nyoog 9 txog 48 lub hlis (hnub nyoog nruab nrab, 22 lub hlis; 55% txiv neej; 61% Neeg Mev dawb) nrog kev noj zaub mov tsis muaj hlau tsis txaus anemia Puas muaj txiaj ntsig zoo dua.ferrous sulfatence hemoglobin concentration.
Thaum lub Cuaj Hlis 2013 thiab Kaum Ib Hlis 2015, cov kws tshawb fawb tau muab cov menyuam yaus tau txais 3 mg / kg ntawm cov hlau hlau ib hnub ib zaug raws li ferrous sulfate tee (n = 40) lossis hlau-polysaccharide complex tee (n = 40) = 40) rau 12 lub lis piam. .
Cov niam txiv lossis cov neeg saib xyuas raug qhia kom noj tshuaj txhua hnub thaum sawv ntxov, kom tsis txhob muab cov tshuaj sib xyaw nrog cov zaub mov lossis dej haus, thiab kom tsis txhob muaj mis nyuj rau 1 teev tom qab kev tswj hwm tshuaj.Cov kws tshawb fawb kuj pom zoo kom cov niam txiv thiab cov neeg saib xyuas txwv tsis pub noj mis nyuj rau ib teev. ntau tshaj 600 ml ib hnub twg.
Kev hloov pauv hauv hemoglobin ntawm 12 lub lis piam ua haujlwm yog thawj qhov kawg. Cov ntsiab lus thib ob suav nrog ua tiav kev daws teeb meem ntawm cov hlau tsis muaj ntshav liab, kev hloov pauv hauv cov ntshav ferritin thiab tag nrho cov hlau-txhim kho muaj peev xwm, thiab cov teebmeem tsis zoo.
Tsib caug cuaj tus neeg koom ua tiav qhov kev sim, 28 los ntawm pawg ferrous sulfate thiab 31 los ntawm pawg hlau-polysaccharide complex.
Los ntawm lub hauv paus rau lub lim tiam 12, txhais tau tias hemoglobin nce ntawm 7.9 g / dL mus rau 11.9 g / dL hauv pawg ferrous sulfate thiab los ntawm 7.7 g / dL rau 11.1 g / dL hauv pawg hlau-polysaccharide complex, qhov sib txawv ntau dua ntawm 1 g / dL (95% CI, 0.4-1.6; P < .001) nrog ferrous sulfate.
Piv nrog rau cov pab pawg hlau polysaccharide, cov menyuam mos thiab menyuam yaus hauv pawg ferrous sulfate tau nce siab dua ntawm kev tshem tawm cov hlau deficiency anemia (29% vs 6%; P = .04).Qhov nruab nrab cov ntshav ferritin qib nce ntawm 3 ng / mL mus rau 15.6 ng / mL nyob rau hauv pawg ferrous sulfate thiab los ntawm 2 ng / mL mus rau 7.5 ng / mL nyob rau hauv cov hlau-polysaccharide complex pawg, nrog ib tug ntau dua sib txawv ntawm 10.2 ng / mL (95 ng / mL).% CI, 6.2-14.1;P <.001) nrog ferrous sulfate.
Qhov nruab nrab ntawm tag nrho cov hlau-binding muaj peev xwm txo los ntawm 501 µg / dL mus rau 389 µg / dL, thaum ferrous sulfate txo los ntawm 506 µg / dL mus rau 417 µg / dL, thiab cov hlau-polysaccharide complex yog -50 µg / dL (95% CI. , -86 rau -14; P < .001) thiab ferrous sulfate.
Kev mob raws plab tau tshwm sim ntau dua nrog cov hlau-polysaccharide complexes dua nrog ferrous sulfate (58% vs 35%; P = .04).
Cov kws tshawb fawb tau sau tseg tias 50 feem pua ntawm cov niam txiv thiab cov neeg zov me nyuam tau tshaj tawm nyuaj rau kev tswj hwm cov hlau-polysaccharide complex, piv nrog 65 feem pua ntawm cov pab pawg ferrous sulfate.
Cov kev txwv ntawm txoj kev tshawb no suav nrog tias nws tau ua nyob rau hauv tsev kho mob menyuam yaus hauv tsev kho mob thiab muaj qhov tsis sib xws ntawm cov neeg tau nyiaj tsawg thiab cov neeg tsawg tsawg uas muaj ntshav tsis txaus, txog 23% ntawm cov neeg uas xav tau ntshav ntshav ua ntej tso npe kawm.
"Cov txiaj ntsig no yuav tsum pab ua kom muaj kev sim tshuaj ntxiv txhawm rau ntsuas qis lossis tsawg dua cov koob tshuaj ntawm qhov ncauj," Powers thiab cov npoj yaig tau sau. "Cov txiaj ntsig xav tau tuaj yeem suav nrog kev txhim kho cov neeg mob ua raws li kev ua raws li cov neeg mob thiab txhim kho kev nqus hlau, ua rau muaj txiaj ntsig zoo dua hematologic teb. "- Chuck Gormley
Kev Tshaj Tawm: Gensavis Pharmaceuticals tau pab nyiaj rau txoj kev tshawb fawb no.Cov kws tshawb fawb qhia tsis muaj qhov cuam tshuam txog nyiaj txiag.
Post lub sij hawm: Mar-21-2022