Mmetụta mgbochi ịba nke artemisinin

[Nlebanya]
Artemisinin (QHS) bụ akwụkwọ akụkọ sesquiterpene lactone nwere àkwà mmiri peroxy dịpụrụ adịpụ na ọgwụ herbal Chinese Artemisia annua L. Artemisinin nwere nhazi pụrụ iche, arụmọrụ dị elu na nsi dị ala.Ọ nwere mgbochi tumor, mgbochi tumo, mgbochi nje, mgbochi ịba, na mgbochi na-akwalite ọgwụ mmetụta.Ọ nwere mmetụta pụrụ iche na mmetọ ụdị ụbụrụ na mmetọ ọjọọ.Ọ bụ naanị ọgwụ ịba na mba ụwa amatala na China.Ọ bụrụla ọgwụ kacha mma maka ọgwụgwọ ịba nke Òtù Ahụ Ike Ụwa tụrụ aro.
[Ihe gbasara anụ ahụ na kemịkalụ]
Artemisinin bụ kristal agịga na-enweghị agba nke nwere ebe mgbaze nke 156 ~ 157 Celsius C. Ọ dị mfe soluble na chloroform, acetone, ethyl acetate na benzene.Ọ na-agbaze na ethanol, ether, soluble ntakịrị na mmanụ mmanụ oyi, na ọ fọrọ nke nta ka ọ ghara ịsacha ya na mmiri.N'ihi otu peroxy pụrụ iche, ọ na-esighi ike ikpo ọkụ ma na-emebi ngwa ngwa site na mmetụta nke mmiri, ọkụ na ibelata ihe.
[Pharmacological omume]
1. Mgbochi ịba mmetụta Artemisinin nwere ihe pụrụ iche na-emepụta ọgwụ na-enwe mmetụta ọgwụgwọ dị mma na ịba.N'ime ihe mgbochi ịba nke artemisinin, artemisinin na-akpata nkwụsị nke nhazi nke ikpuru kpamkpam site na itinye aka na akpụkpọ ahụ-mitochondrial ọrụ nke nje ịba.Isi nyocha nke usoro a bụ nke a: otu peroxy dị na molecular Ọdịdị nke artemisinin na-emepụta free radicals site oxidation, na free radicals na-ejikọta protein ịba, si otú ahụ na-eme ihe na akpụkpọ ahụ nke parasitic protozoa, na-ebibi akpụkpọ ahụ. akpụkpọ anụ ahụ na plasma ọbara.Mitochondria fụrụ akpụ na akpụkpọ ahụ dị n'ime na nke dị n'èzí na-apụ apụ, mechaa mebie nhazi cell na ọrụ nke nje ịba.N'ime usoro a, chromosomes dị na nucleus nke nje ịba na-emetụtakwa.Nleba anya na eletrọnịkị microscopy na-egosi na artemisinin nwere ike banye ozugbo n'ụdị akpụkpọ ahụ nke Plasmodium, nke nwere ike igbochi nri nri nke mkpụrụ ndụ ọbara uhie nke Plasmodium dabere na ya, wee si otú a na-egbochi ọrụ akpụkpọ ahụ-mitochondrial nke Plasmodium (Kama ịkpaghasị ya. folate metabolism, ọ na-emecha na-eduga na ndakpọ zuru oke nke nje ịba ahụ, itinye artemisinin na-ebelatakwa oke isoleucine nke Plasmodium na-etinye, si otú ahụ na-egbochi njikọ nke protein na Plasmodium.
Tụkwasị na nke ahụ, mmetụta antimalarial nke artemisinin na-emetụtakwa ikuku oxygen, na ikuku oxygen dị elu ga-ebelata ịdị irè nke artemisinin na P. falciparum omenala in vitro.A na-ekewa mbibi nke nje ịba site na artemisinin ụzọ abụọ, otu bụ ibibi nje ịba ozugbo;nke ọzọ bụ imebi mkpụrụ ndụ ọbara uhie nke nje ịba, nke na-eduga na ọnwụ nke nje ịba.Mmetụta antimalarial nke artemisinin nwere mmetụta igbu mmadụ ozugbo na akụkụ erythrocyte nke Plasmodium.Enweghị mmetụta dị ịrịba ama na usoro tupu na extra-erythrocytic.N'adịghị ka ọgwụ ịba ndị ọzọ, usoro mgbochi ịba nke artemisinin na-adabere karịsịa na peroxyl na nhazi ihe omimi nke artemisinin.Ọnụnọ nke otu peroxyl na-ekere òkè dị mkpa na ọrụ mgbochi ịba nke artemisinin.Ọ bụrụ na enweghị otu peroxide, artemisinin ga-atụfu ọrụ mgbochi ịba.Ya mere, enwere ike ikwu na usoro antimalarial nke artemisinin nwere njikọ chiri anya na mmeghachi omume decomposition nke ìgwè peroxil.Na mgbakwunye na mmetụta dị mma igbu ya na nje ịba, artemisinin nwekwara mmetụta mgbochi ụfọdụ na nje ndị ọzọ.
2. Mgbochi tumor mmetụta Artemisinin nwere doro anya inhibitory mmetụta na uto nke dị iche iche akpụ mkpụrụ ndụ dị ka imeju cancer mkpụrụ ndụ, ara cancer mkpụrụ ndụ na cervical cancer mkpụrụ ndụ.Ọtụtụ nchọpụta egosila na artemisinin nwere otu usoro eji eme ihe megide ịba na mgbochi ọrịa kansa, ya bụ, mgbochi ịba na mgbochi ọrịa kansa site na free radicals nke peroxy bridge breaks na molecular Ọdịdị nke artemisinin.Na otu artemisinin derivative bụ nhọrọ maka igbochi ụdị mkpụrụ ndụ etuto dị iche iche.Omume artemisinin na mkpụrụ ndụ etuto na-adabere na ntinye nke apoptosis cell iji mechaa igbu mkpụrụ ndụ tumo.N'otu mmetụta ahụ mgbochi ịba, dihydroartemisinin na-egbochi mkpali nke ihe na-akpata hypoxia site na ịbawanye otu oxygen na-emeghachi omume.Dịka ọmụmaatụ, mgbe ọ rụsịrị ọrụ na akpụkpọ ahụ nke mkpụrụ ndụ leukemia, artemisinin nwere ike ịbawanye ụba nke calcium intracellular site na ịgbanwe permeability nke akpụkpọ ahụ cell ya, nke na-abụghị nanị na-eme ka calpain dị na sel leukemia, kamakwa na-akwalite mwepụta nke ihe apoptotic.Mee ngwa ngwa nke apoptosis.
3. Mmetụta immunomodulatory Artemisinin nwere mmetụta nchịkwa na usoro ahụ ji alụso ọrịa ọgụ.N'okpuru ọnọdụ na usoro onunu ogwu nke artemisinin na usoro ya anaghị akpata cytotoxicity, artemisinin nwere ike igbochi T lymphocyte mitogen nke ọma, wee si otú a mee ka mmụba nke lymphocytes splin na ụmụ oke.Artesunate nwere ike ịbawanye mkpokọta mmeju nke serum mouse site n'ịkwalite mmetụta nke mgbochi na-abụghị nke akọwapụtara.Dihydroartemisinin nwere ike igbochi mmụba nke lymphocytes B ozugbo wee belata nzuzo nke autoantibodies site na B lymphocytes, si otú a na-egbochi mmeghachi omume mgbochi ihu ọchị.
4. Arụ ọrụ antifungal A na-egosipụta mmetụta antifungal nke artemisinin na mgbochi ya nke fungi.Artemisinin slag ntụ ntụ na decoction nwere mmetụta mgbochi siri ike na Staphylococcus epidermidis, Bacillus anthracis, diphtheria na catarrhalis, ma nweekwa mmetụta ụfọdụ na Pseudomonas aeruginosa, Shigella, Mycobacterium ụkwara nta na Staphylococcus aureus.Mgbochi.
5. Anti-Pneumocystis carinii ka oyi baa mmetụta Artemisinin tumadi na-ebibi Ọdịdị nke Pneumocystis carinii membrane system, na-eme ka vacuoles na cytoplasm na ngwugwu nke sporozoite trophozoites, mitochondria mbufụt, nuclear akpụkpọ mgbawa, ọzịza nke endoplasmic reticulum, dị otú ahụ discaps. ultrastructural mgbanwe.
6. Mgbochi ime mmetụta ọgwụ Artemisinin nwere oke nhọrọ toxicity na embrayo.Obere doses nwere ike ime ka embrayo nwụọ wee bute ime ime.Enwere ike ịmepụta ya dị ka ọgwụ ite ime.
7. Anti-Schistosomiasis Otu mgbochi schistosomiasis nọ n'ọrụ bụ àkwà mmiri peroxy, na usoro ọgwụgwọ ya bụ imetụta metabolism shuga nke ikpuru.
8. Mmetụta obi obi Artemisinin nwere ike igbochi arrhythmia nke ọma site na ligation nke akwara obi, nke nwere ike igbu oge mmalite nke arrhythmia nke calcium chloride na chloroform kpatara, ma na-ebelata ventricular fibrillation nke ukwuu.
9. Mgbochi fibrosis Ọ na-emetụta igbochi fibroblast proliferation, ibelata njikọ nke collagen, na antihistamine-induced collagen decomposition.
10. Mmetụta ndị ọzọ Dihydroartemisinin nwere mmetụta mgbochi dị ịrịba ama na Leishmania donovani ma na-ejikọta dose.Artemisia annua wepụ na-egbukwa Trichomonas vaginalis na lysate amoeba trophozoites.