Ụmụaka na ụmụaka dị ọnwa 9 ruo afọ 4 nwere anaemia na-edozi ahụ na-edozi ahụ nwere mmụba dị ukwuu na mkpokọta hemoglobin na ferrous sulfate karịa nke nwere ígwè-polysaccharide complexes na izu 12, dịka nyocha ụlọ ọgwụ na-enweghị usoro nke e bipụtara na JAMA.Nnukwu.
Anaemia erughi ígwè na ụmụ ọhụrụ na ụmụntakịrị - nke a na-ebutekarị site na ịṅụbiga mmanya ókè ma ọ bụ inye nwa ara ogologo oge na-enweghị mgbakwunye ígwè kwesịrị ekwesị - metụtara ihe karịrị ijeri mmadụ 1 n'ụwa nile na 2010, 3% n'ime ha bụ 1 ruo 2 ụmụaka nọ na America. .Ọ na-emekarị n'ime ụmụaka na-eto ngwa ngwa ma nwee ike ịkpata mgbakasị ahụ, ahụ erughị ala, pica, na nsogbu neurodevelopmental nke mkpụmkpụ na ogologo oge.
Ferrous sulfate, Nnu ígwè, bụ ọgwụgwọ ọkọlọtọ maka anaemia na-edozi ahụ na-edozi ahụ. Otú ọ dị, ígwè-polysaccharide mgbagwoju nke nwere ígwè ferric (NovaFerrum, Gensavis Pharmaceuticals) nwere ike iji mee ihe dị ka ihe ọzọ n'ihi na ọ nwere ike melite ndidi na uto.
"Ọgwụgwọ ọgwụgwọ na-adịkarị n'ihi ọgwụ na-adịghị anabata ọgwụ, mmetụta ọjọọ ndị metụtara ịṅụbiga mmanya ókè, na enweghị ụkpụrụ nduzi nlekọta na-egosi," Jacquelyn M. Powers, MD, MS, Ụlọ Akwụkwọ Ọgwụ, Baylor Assistant Prọfesọ nke Pediatrics na Hematology kwuru. / Oncology, na ndị ọrụ ibe dere. "Ọnwụnwa ole na ole na-enweghị usoro na-egosi nhọrọ nhazi ígwè, usoro dose, na oge ọgwụgwọ, n'agbanyeghị ọdịdị etiology, afọ, ma ọ bụ mmekọahụ nke ndị ọ metụtara."
Ndị ikike na ndị ọrụ ibe nyochara ogige iron-polysaccharide na ụmụ ọhụrụ 80 na ụmụaka 9 ruo ọnwa 48 (afọ etiti, ọnwa 22; 55% nwoke; 61% ọcha Hispanic) na ụkọ iron erughi anaemia Ọ dị irè karịaferrous sulfateiji mụbaa mkpokọta hemoglobin.
N'agbata Septemba 2013 na Nọvemba 2015, ndị nchọpụta ahụ kenyere ụmụaka ka ha nata 3 mg / kg nke iron elemental otu ugboro kwa ụbọchị dị ka ferrous sulfate drops (n = 40) ma ọ bụ iron-polysaccharide complex drops (n = 40) = 40) maka izu iri na abụọ. .
A gwara ndị nne na nna ma ọ bụ ndị nlekọta ka ha na-edozi dose ahụ kwa ụbọchị n'oge ụra, iji zere ịgwakọta dose ahụ na nri ma ọ bụ ihe ọṅụṅụ ọ bụla, na izere mmiri ara ehi maka awa 1 mgbe nchịkwa nke ọgwụ ọmụmụ. kacha 600 ml kwa ụbọchị.
Mgbanwe na hemoglobin na izu iri na abụọ na-eje ozi dị ka isi njedebe. Ihe njedebe nke abụọ gụnyere mkpebi zuru oke nke ụkọ iron erughi anaemia, mgbanwe nke serum ferritin ọkwa na ngụkọta ígwè-ejikọta ike, na mmetụta ọjọọ.
Ndị sonyere iri ise na itoolu mechachara nnwale ahụ, 28 sitere na otu ferrous sulfate na 31 sitere na otu iron-polysaccharide complex.
Site na ntọala ruo izu 12, pụtara hemoglobin mụbara site na 7.9 g/dL ruo 11.9 g/dL na ferrous sulfate otu yana site na 7.7 g/dL ruo 11.1 g/dL na iron-polysaccharide complex group, nnukwu ọdịiche nke 1 g / dL (95% CI, 0.4-1.6; P <.001) na ferrous sulfate.
E jiri ya tụnyere ndị otu polysaccharide iron, ụmụ ọhụrụ na ụmụaka nọ na ferrous sulfate Group nwere ọnụ ọgụgụ dị elu nke mgbaghara zuru oke nke ụkọ iron erughi anaemia (29% vs 6%; P = .04) .Mkpụrụ ndụ serum ferritin dị n'etiti mụbara site na 3 ng/mL ruo 15.6 ng / mL na ferrous sulfate otu na site na 2 ng / mL ka 7.5 ng / mL na ígwè-polysaccharide mgbagwoju otu, na nnukwu ọdịiche nke 10.2 ng / mL (95 ng / mL).% CI, 6.2-14.1;P <.001) na ferrous sulfate.
Ngụkọta ọnụ ike njide ígwè gbadara site na 501 µg/dL ruo 389 μg/dL, ebe ferrous sulfate belatara site na 506 µg/dL ruo 417 μg/dL, na ígwè-polysaccharide complex bụ -50 μg/dL (95% CI). , -86 ruo -14; P <.001) na ferrous sulfate.
Ọrịa afọ ọsịsa na-enwekarị ogige iron-polysaccharide karịa na ferrous sulfate (58% vs 35%; P = .04).
Ndị nchọpụta ahụ kwuru na pasent 50 nke ndị nne na nna na ndị nlekọta na-akọ na ọ na-esiri ha ike ijikwa ígwè-polysaccharide mgbagwoju anya, ma e jiri ya tụnyere pasent 65 nke ìgwè sulfate ferrous.
Oke nke ọmụmụ ahụ gụnyere na a na-eduzi ya n'ụlọ ọgwụ ụmụaka na-elekọta ụlọ akwụkwọ sekọndrị ma nwee ọnụ ọgụgụ na-ezighị ezi nke ndị na-enweghị ego na ndị na-arịa ọrịa dị nta na-arịa ọrịa anaemia siri ike, ihe dị ka 23% n'ime ha chọrọ mmịnye ọbara tupu ha edebanye aha.
"Nsonaazụ ndị a kwesịrị inye aka mee ka nyocha ọzọ ụlọ ọgwụ iji nyochaa obere ma ọ bụ obere oge nke ígwè ọnụ," Ike na ndị ọrụ ibe dere." Nsonaazụ a na-atụ anya ya nwere ike ịgụnye nrubeisi nke ndị ọrịa na mmụba ígwè, na-ebute nzaghachi hematologic dị mma karị."- Chuck Gormley
Nkpughe: Gensavis Pharmaceuticals kwadoro ọmụmụ ihe a. Ndị nyocha ahụ akọpụtaghị nkwupụta ego dị mkpa.
Oge nzipu: Mar-21-2022