Chloramphenicol Sodium Succinatendi ufa woyera kapena wachikasu-woyera wa hygroscopic.1.4 g ya chinthu cha monograph pafupifupi pafupifupi 1 g ya chloramphenicol.
Kusamala
Chtoramphenicot ndi contraindicated odwala ndi mbiri ya hypersensitivity kapena poizoni anachita mankhwala.Siyenera kuperekedwa mwadongosolo kwa matenda ang'onoang'ono kapena prophylaxis.Kugwiritsa ntchito munthawi yomweyo chtoramphenicot ndi mankhwala ena omwe amachepetsa maliro a m`mafupa kuyenera kupewedwa.Kutsekedwa kwafupika kuyenera kuperekedwa kwa odwala omwe ali ndi vuto la chiwindi.Chloramphemcol ikhoza kusokoneza kukula kwa chitetezo chamthupi ndipo sayenera kuperekedwa panthawi yobaya katemera.
Kuyanjana
Chloramphenicol imapangidwa m'chiwindi ndipo imatha kuyanjana ndi mankhwala omwe amapangidwa ndi hepatic microsomal enzymes.Mwachitsanzo, chloramphenicol timapitiriza zotsatira za coumarm anticoagulants monga dicoumarol ndi warfarin sodium, ena hypoglycemic monga chlorpropamide ndi tolbutamide, ndi antiepiteptics monga phenytoin, ndipo akhoza kuchepetsa kagayidwe wa cuctophosphamufe kuti yogwira mawonekedwe.Kumbali ina, kagayidwe ka chloramphemcol kachulukidwe ndi ma enzymes a chiwindi monga phenobarbitone kapena nfampicin.Zotsatira zotsutsana zanenedwa ndi paracetamol ndi phenytoin.Chloramphenicol amachepetsa mphamvu ya chitsulo ndi vitamini Bi2 mwa odwala omwe ali ndi vuto la kuchepa kwa magazi komanso kusokoneza njira zakulera zamkamwa.
Antimicrobial Action
Chloramphe.nicol ndi g bacteriostatic antibiotic yokhala ndi zochita zambiri zolimbana ndi mabakiteriya a gram-positive ndi gram-negative, komanso zamoyo zina.
Ntchito ndi Administration
V Udindo, wa chloranphenicol woyambitsa zotsatira zowopsa, makamaka aplasia ya m'mafupa,.yachepetsa kwambiri ntchito yake yachipatala, ngakhale kuti imagwiritsidwabe ntchito kwambiri m'mayiko ena.Siziyenera kukhala giyen mwadongosolo, chifukwa matenda ang'onoang'ono komanso kuchuluka kwa magazi nthawi zambiri kumakhala koyenera panthawi ya chithandizo.Ma cephalosporins a m'badwo wachitatu tsopano amakondedwa chifukwa cha zizindikiro zambiri zakale za chlorampheniclo.Pachifukwa ichi, pali zizindikiro zochepa zodziwika bwino zogwiritsira ntchito chloramphenicol.Amagwiritsidwa ntchito kwambiri pa matenda a typhoid ndi matenda ena a salmonella, ngakhale kuti sathetsa boma la wopeza.Chloramphenicol ndi m'malo mwa m'badwo wachitatu cephalosporin pochiza bacterial meningitis, ponseponse movutikira komanso motsutsana ndi tizilombo tating'onoting'ono monga Haemophtlus tnfluenzae.Zagwiritsidwa ntchito pochiza matenda aakulu a anaerobic, patricularly mu abscesses mu ubongo, ndi matenda omwe ali pansi pa diaphragm kumene Bacteroides fragitis nthawi zambiri amakhudzidwa;komabe, mankhwala ena nthawi zambiri amawakonda.Ngakhale kuti tetracyclines amakhalabe mankhwala omwe amasankhidwa pa matenda a rickettsial monga typhus ndi s,potted fevers, chforamphenicol amagwiritsidwanso ntchito ngati njira ina yomwe tetracyclines, sangaperekedwe.
Matenda ena a bakiteriya omwe chloramphenicol angagwiritsidwe ntchito ngati m'malo mwa mankhwala ena monga anthrax, matenda oopsa a Campylobacter fetus, ehrlichiosis, gastro-ententis, gas gangrene, granuloma inguinale, matenda oopsa a Haemophitus influenzae kupatula meninjitisi (mwachitsanzo, epiglottitis), listeriosis, metioidosis yoopsa, mliri (makamaka ngati meningitis yayamba), psittacosis, tularaemia (makamaka[y pamene akuganiziridwa kuti meningitis), ndi matenda a Whipple.Chifukwa, zambiri za matendawa ndi chithandizo chawo..
Chioramphenicol imagwiritsidwa ntchito kwambiri pamankhwala apakhungu, khutu komanso, makamaka, zotupa zamaso, ngakhale kuti ambiri mwa awa ndi ofatsa komanso odziletsa.Amagwiritsidwanso ntchito pamitu m pochiza matenda a skm.Mlingo amawonetsedwa m'magawo a chloramphenicol m'munsi ndipo ndi ofanana kaya ndi pakamwa kapena kudzera m'mitsempha.Kwa akulu ndi ana, mlingo wamba ndi 5O mg pa kilogalamu ya kulemera kwa thupi tsiku lililonse m'maola 6 aliwonse;mpaka 100 mg pa kilogalamu imodzi patsiku atha kupatsidwa matenda oumitsa khosi kapena matenda oopsa chifukwa cha tizilombo tosamva mphamvu, ngakhale kuti Mlingo wokwerawu uyenera kuchepetsedwa posachedwa.Kuchepetsa nsk wa muyambirenso analimbikitsa kuti mankhwala contmued pambuyo kutentha kwa wodwalayo kubwerera mwakale kwa masiku 4 m nckettsial matenda ndi 8 mpaka 10 masiku tayifodi lever.
Ngati palibe njira ina yogwiritsira ntchito çhloramphenicol, asanakwane komanso achikulire, ana akhanda amatha kupatsidwa Mlingo watsiku ndi tsiku wa 25 mg pa kilogalamu ya kulemera kwa thupi ndi makanda opitilira zaka 2, mpaka 50 mg. pa kg tsiku lililonse, m 4 anagawa Mlingo: Momtoring wa plasma woipa n`kofunika kupewa kawopsedwe.
Odwala ndi mkhutu he.patic ntchito kapena kwambiri aimpso inipainnent mlingo wa chloramphenicol angafunikire recfuced chifukwa kuchepa cimelabolism kapena excretion.
Mankhwalawa diso mfections chloramphenicol nthawi ntchito monga 0,5% njira kapena 1% mafuta.
Zotsatira zake
Chloramphemcol imatha kuyambitsa zovuta komanso nthawi zina zowopsa.Zina mwazowopsa zake zimaganiziridwa kuti zimachitika chifukwa cha kaphatikizidwe ka mapuloteni a mitochondnal.Choyipa chachikulu kwambiri cha chloramphemcol ndi kupsinjika kwa m'mafupa, komwe kumatha kutenga mitundu iwiri yosiyana.Yoyamba ndi yodziwika bwino yokhudzana ndi kupsinjika kwamankhwala komwe kumachitika nthawi zambiri pamene kuchuluka kwa plasma-chloramphenicol kupitilira 25 ug permL ndipo kumadziwika ndi ma morphological chap m m'mafupa, kuchepa kwachitsulo, reticulocylopenia anemia, leukopenia ndi thrombocytopenia.Izi zikhoza kukhala chifukwa chopinga wa kaphatikizidwe mapuloteni mu mitochomária m`mafupa maselo., Hypersensitivity zimachitikira mctuding totupa, malungo, ndi angioedema zikhoza kuchitika makamaka apakhungu ntchito;Anaphylaxis yachitika koma ndizosowa, mawonekedwe a Jansch-Herxheimer amathanso kuchitika.Zizindikiro za m'mimba monga nseru, kusanza, ndi kutsekula m'mimba zimatha kutsatiridwa ndi kumwa.Kusokonezeka kwa zomera za m'kamwa ndi m'mimba, kungayambitse stomatitis, glossitis, ndi kuyabwa kwa rectum, Odwala amatha kumva kukoma kowawa kwambiri potsatira mofulumira mtsempha wa chloramphenicot sodium succinate.
Kuchulukitsa
Makala haemoperfusion anapezeka kuti ndi wapamwamba kwambiri kuposa kusinthana kuikidwa magazi mu remval wa chloramphenicol mawonekedwe magazi, ngakhale kuti mot kuteteza imfa ma 7-sabata zakubadwa mfant ndi imvi mwana syndrome kutsatira vuto crosage.
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