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Kwa nthawi yopitilira chaka chimodzi, Adeola Fowotade wakhala akuyesera kulemba anthu kuti akayesetse kulandira chithandizo chamankhwala a COVID-19. Cholinga chake ndikupeza anthu 50 odzipereka - anthu omwe adapezeka ndi COVID-19 omwe ali ndi zizindikiro zochepa kapena zowopsa komanso omwe angapindule ndi malo ogulitsa mankhwala. m’mwezi wa January ndi February. Patatha miyezi isanu ndi itatu, analembera anthu 44 okha.
"Odwala ena anakana kutenga nawo mbali mu phunziroli atayandikira, ndipo ena adavomereza kuti asiye pakati pa mayesero," adatero Fowotade. Pomwe chiwerengero cha milandu chinayamba kutsika mu March, zinali zosatheka kupeza otenga nawo mbali.Izi zinapangitsa kuti mayeserowo adziwike. monga NACOVID, ndizovuta kumaliza." Sitinathe kukwaniritsa kukula kwa zitsanzo zomwe tinakonza," adatero.
Mavuto a Fowotade akuwonetsa zovuta zomwe mayesero ena akukumana nawo ku Africa - vuto lalikulu kumayiko akukontinenti omwe alibe mwayi wopeza katemera wokwanira wa COVID-19. Katemera pang'ono. Izi ndizotsika pang'ono poyerekeza ndi mayiko omwe ali ndi ndalama zochepa. Ziwerengero zikusonyeza kuti mayiko a mu Africa sadzakhala ndi mlingo wokwanira kuti atemere 70% ya anthu onse a ku Africa mpaka osachepera September 2022.
Izi zikusiya njira zingapo zothanirana ndi mliriwu. perekani chilolezo kwa mankhwala opangidwa ndi mapiritsi a molnupiravir kwa opanga komwe angagwiritsidwe ntchito kwambiri, koma mafunso akadali okhudza kuchuluka kwa ndalama ngati atavomerezedwa. Zotsatira zake, Africa ikupeza mankhwala otsika mtengo, opezeka mosavuta omwe angachepetse zizindikiro za COVID-19, kulemetsa kwa matenda pamadongosolo azachipatala, ndikuchepetsa kufa.
Kufufuzaku kwakumana ndi zopinga zambiri. Mwa mayesero pafupifupi 2,000 omwe akufufuza chithandizo chamankhwala cha COVID-19, pafupifupi 150 okha ndi omwe adalembetsedwa ku Africa, ochulukirapo ku Egypt ndi South Africa, malinga ndi Clinictrials.gov, nkhokwe yoyendetsedwa ndi United. Kuperewera kwa mayeso ndi vuto, akutero Adeniyi Olagunju, dokotala wazachipatala ku yunivesite ya Liverpool ku UK komanso wofufuza wamkulu wa NACOVID. zochepa kwambiri, adatero. ”Onjezaninso pakuchepa kwa katemera,” adatero Oragonju.
Mabungwe ena akuyesera kuthana ndi vutoli. ANTICOV, pulogalamu yoyendetsedwa ndi bungwe lopanda phindu la Drugs for Neglected Diseases Initiative (DNDi), pano ndiyo kuyesa kwakukulu mu Africa. Kafukufuku wina wotchedwa Repurposing Anti-Infectives for COVID-19 Therapy (ReACT) - wogwirizana ndi bungwe lopanda phindu la Medicines for Malaria Venture - adzayesa chitetezo ndi mphamvu ya kubwezeretsanso mankhwala ku South Africa. za zomangamanga, ndi zovuta zolembera anthu omwe atenga nawo gawo pazoyeserera ndizomwe zimalepheretsa izi.
"Kum'mwera kwa Sahara ku Africa, dongosolo lathu lachipatala lagwa," adatero Samba Sow, wofufuza wamkulu wa dziko ku ANTICOV ku Mali.Izi zimapangitsa kuti mayesero akhale ovuta, koma ofunikira, makamaka pozindikira mankhwala omwe angathandize anthu kumayambiriro kwa matendawa. ndi kupewa kugonekedwa m’chipatala. Kwa iye ndi anthu ena ambiri amene amaphunzira za matendawa, ndi mpikisano wolimbana ndi imfa.” Sitingadikire mpaka wodwala adwale kwambiri,” iye anatero.
Mliri wa coronavirus wakulitsa kafukufuku wachipatala ku Africa. Katswiri wa katemera Duduzile Ndwandwe amatsata kafukufuku wamankhwala oyesera ku Cochrane South Africa, gawo la bungwe lapadziko lonse lomwe limawunikanso umboni wa zaumoyo, ndipo adati Pan-African Clinical Trials Registry idalembetsa mayeso 606 mu 2020. , poyerekeza ndi 2019 408 (onani 'Mayesero a Zachipatala ku Africa').Pofika mu Ogasiti chaka chino, idalembetsa mayeso 271, kuphatikiza kuyesa kwa katemera ndi mankhwala.Ndwandwe adati: "Tawona mayesero ambiri akukulitsa kuchuluka kwa COVID-19."
Mu Marichi 2020, bungwe la World Health Organisation (WHO) lidayambitsa mayeso a Solidarity Trial, kafukufuku wapadziko lonse lapansi wamankhwala anayi omwe atha kudwala COVID-19. Ndi mayiko awiri okha aku Africa omwe adatenga nawo gawo gawo loyamba la kafukufukuyu. .Vuto lopereka chithandizo chamankhwala kwa odwala omwe akudwala kwambiri lalepheretsa mayiko ambiri kulowa nawo, anatero Quarraisha Abdool Karim, katswiri wa miliri wa pa yunivesite ya Columbia ku New York City, ku Durban, South Africa.” Uwu ndi mwayi wofunika kwambiri womwe tinaphonya.” Adati, koma zikhazikitsa njira yoyesereranso chithandizo chamankhwala a COVID-19. Mu Ogasiti, World Health Organisation idalengeza gawo lotsatira la kuyesa kwa mgwirizano, komwe kudzayesa mankhwala ena atatu. Mayiko ena asanu a ku Africa adatenga nawo gawo.
Mlandu wa NACOVID wopangidwa ndi Fowotade akufuna kuyesa chithandizo chophatikiza pa anthu 98 ku Ibadan ndi malo ena atatu ku Nigeria. sanakumanepo, Olagunju adati gululi likukonzekera zolembedwa kuti zifalitsidwe ndipo akuyembekeza kuti zomwe zafotokozedwazo zipereka zidziwitso zamphamvu ya mankhwalawa.
Mayesero a South African ReACT, omwe athandizidwa ku Seoul ndi kampani yopanga mankhwala ya ku South Korea ya Shin Poong Pharmaceutical, akufuna kuyesa mitundu inayi ya mankhwala omwe agwiritsidwanso ntchito: mankhwala oletsa malungo artesunate-amodiaquine ndi pyrrolidine-artesunate;Favipiravir, mankhwala a chimfine omwe amagwiritsidwa ntchito limodzi ndi nitre;ndi sofosbuvir ndi daclatasvir, mankhwala opha tizilombo toyambitsa matenda omwe amagwiritsidwa ntchito pochiza matenda a chiwindi C.
Kugwiritsa ntchito mankhwala obwezeretsanso kumakhala kokongola kwambiri kwa ochita kafukufuku ambiri chifukwa ikhoza kukhala njira yotheka kwambiri yopezera chithandizo mwamsanga chomwe chingagawidwe mosavuta.Kusowa kwa Africa kwa kafukufuku wa mankhwala osokoneza bongo, chitukuko ndi kupanga kumatanthauza kuti mayiko sangathe kuyesa mankhwala atsopano ndi mankhwala ochuluka. .Kuyesetsa kumeneku n’kovuta kwambiri, akutero Nadia Sam-Agudu, katswiri wa matenda opatsirana a ana pa yunivesite ya Maryland yemwe amagwira ntchito ku Nigeria Institute of Human Virology ku Abuja.” Ngati n’kotheka, chithandizochi chingalepheretse matenda aakulu ndi kugona m’chipatala, komanso mwina [imitsani] kupitiliza kufalitsa," adawonjezera.
Mlandu waukulu kwambiri padziko lonse lapansi, ANTICOV, udakhazikitsidwa mu Seputembara 2020 ndikuyembekeza kuti chithandizo chanthawi yayitali chingalepheretse COVID-19 kusokoneza machitidwe azaumoyo aku Africa. Faso, Guinea, Mali, Ghana, Kenya ndi Mozambique. Cholinga chake ndi kulemba anthu 3,000 m'maiko 13.
Wogwira ntchito kumanda ku Dakar, Senegal, mu Ogasiti pomwe funde lachitatu la matenda a COVID-19 lidagunda. Ngongole ya zithunzi: John Wessels/AFP/Getty
ANTICOV ikuyesa mphamvu ya mankhwala osakaniza awiri omwe akhala ndi zotsatira zosakanikirana kwinakwake.Yoyamba imasakaniza nitazoxanide ndi ciclesonide yopumira, corticosteroid yomwe imagwiritsidwa ntchito pochiza mphumu.Wachiwiri amaphatikiza artesunate-amodiaquine ndi antiparasitic drug ivermectin.
Kugwiritsa ntchito ivermectin mumankhwala azinyama komanso kuchiza matenda ena onyalanyazidwa mwa anthu kwadzetsa mikangano m'maiko ambiri. Ku Egypt, kafukufuku wamkulu wochirikiza kugwiritsa ntchito ivermectin kwa odwala a COVID-19 adachotsedwa ndi seva yosindikizira itatha kusindikizidwa pakati pa milandu yolakwika ndi kubera. (Olemba kafukufukuyu akuti osindikiza sanawapatse mpata wodziteteza.) Ndemanga yaposachedwa ya Cochrane Infectious Diseases Group sinapeze umboni wotsimikizira kugwiritsa ntchito ivermectin pochiza matenda a COVID-19 (M. Popp et al. Cochrane Database Syst. Rev. 7, CD015017; 2021).
Nathalie Strub-Wourgaft, yemwe amayendetsa kampeni ya DNDi ya COVID-19, adati pali chifukwa chomveka choyesera mankhwalawa ku Africa. atapezeka kuti akusowa, DNDi yakonzeka kuyesa mankhwala ena.
"Nkhani ya ivermectin yakhala ndi ndale," adatero Salim Abdool Karim, katswiri wa miliri komanso mkulu wa bungwe la Durban-based Center for AIDS Research ku South Africa (CAPRISA)." , ndiye kuti ndi maganizo abwino.”
Kutengera zomwe zilipo mpaka pano, kuphatikiza kwa nitazoxanide ndi ciclesonide kumawoneka ngati kolimbikitsa, Strub-Wourgaft adati. -Wourgaft adati ANTICOV ikukonzekera kuyesa mkono watsopano ndipo idzapitiriza kugwiritsa ntchito zida ziwiri zomwe zilipo kale.
Kuyamba kuyesa kunali kovuta, ngakhale kwa DNDi yemwe ali ndi chidziwitso chochuluka cha ntchito ku Africa.Kuvomerezedwa ndi malamulo ndi vuto lalikulu, adatero Strub-Wourgaft. ndondomeko yochitira kafukufuku wophatikizana wa maphunziro a zachipatala m'mayiko a 13. Izi zikhoza kufulumizitsa zovomerezeka zovomerezeka ndi zamakhalidwe abwino. "Zimatithandiza kusonkhanitsa mayiko, olamulira ndi mamembala a bungwe loyang'anira chikhalidwe," adatero Strub-Wourgaft.
Nick White, katswiri wazachipatala yemwe ndi wapampando wa COVID-19 Clinical Research Consortium, mgwirizano wapadziko lonse lapansi kuti apeze mayankho ku COVID-19 m'maiko opeza ndalama zochepa, adati ngakhale njira ya WHO inali yabwino, koma zimatenga nthawi yayitali kuti avomerezedwe. , ndipo kafukufuku m'mayiko osauka ndi apakati ndi abwino kusiyana ndi kafukufuku m'mayiko olemera.Zifukwa zikuphatikizapo malamulo okhwima okhwima m'mayikowa, komanso maulamuliro omwe sali bwino pakuchita kafukufuku wa makhalidwe abwino ndi malamulo.Izi ziyenera kusintha, White adati.
Koma zovuta sizikuthera pamenepo. Mlandu ukangoyamba, kusowa kwa zinthu ndi magetsi kungalepheretse kupita patsogolo, adatero Fowotade. Adasunga zitsanzo za COVID-19 mufiriji -20 ° C panthawi yamagetsi pachipatala cha Ibadan. ikufunikanso kunyamula zitsanzozo kupita ku Ed Center, ulendo wa maola awiri pagalimoto, kuti akafufuzidwe.
Olagunju adawonjezeranso kuti mayiko ena atasiya kupereka ndalama m'malo odzipatula a COVID-19 m'zipatala zawo, kulembera anthu omwe atenga nawo mayeso kudakhala kovuta kwambiri. Popanda izi, odwala okhawo omwe angakwanitse kulipira amaloledwa. mlandu wa ndalama zodzipatula komanso malo ochizira.Palibe amene ankayembekezera kuti asokonezedwa,” adatero Olagunju.
Ngakhale ili ndi zida zambiri, Nigeria sichita nawo gawo pa ANTICOV. ”Aliyense akupewa mayesero azachipatala ku Nigeria chifukwa tilibe bungweli, "atero a Oyewale Tomori, katswiri wazachipatala komanso wapampando wa Unduna wa Unduna wa COVID-19 ku Nigeria. Komiti ya Akatswiri, yomwe imagwira ntchito kuti ipeze njira zogwirira ntchito komanso njira zabwino zothanirana ndi COVID-19.
Babatunde Salako, mkulu wa bungwe la Nigerian Institute of Medical Research ku Lagos, akutsutsa. Salako adati dziko la Nigeria lili ndi chidziwitso chochita mayesero a zachipatala, komanso kulemba anthu ogwira ntchito m'chipatala komanso komiti yowona bwino zamakhalidwe abwino yomwe imagwirizanitsa kuvomereza kwa mayesero a zachipatala ku Nigeria." mawu a zomangamanga, inde, akhoza kukhala ofooka;ikhoza kuthandizirabe mayesero azachipatala, "adatero.
Ndwandwe akufuna kulimbikitsa ofufuza ambiri a ku Africa kuti alowe nawo m'mayesero a zachipatala kuti nzika zake zikhale ndi mwayi wopeza chithandizo chodalirika chamankhwala.Mayesero a m'deralo angathandize ofufuza kuti adziwe mankhwala othandiza.Angathe kuthana ndi zosowa zenizeni m'malo otsika kwambiri ndikuthandizira kukonza zotsatira za thanzi, akutero Hellen Mnjalla. , woyang'anira mayesero achipatala a Wellcome Trust Research Program ku Kenya Institute of Medical Research ku Kilifi.
"COVID-19 ndi matenda opatsirana atsopano, choncho tikufunika mayesero azachipatala kuti timvetsetse momwe izi zingathandizire anthu aku Africa," adawonjezera Ndwandwe.
Salim Abdul Karim akuyembekeza kuti vutoli lilimbikitsa asayansi aku Africa kuti akhazikitse ntchito zina zopangira kafukufuku zomwe zidamangidwa pofuna kuthana ndi mliri wa HIV/AIDS.” Maiko ena monga Kenya, Uganda ndi South Africa ali ndi zida zotukuka kwambiri.Koma madera ena satukuka,” adatero.
Kuti achulukitse mayeso azachipatala a chithandizo cha COVID-19 ku Africa, Salim Abdool Karim akupereka malingaliro opanga bungwe monga Consortium for Clinical Trials of COVID-19 Vaccines (CONCVACT; yopangidwa ndi African Centers for Disease Control and Prevention mu Julayi 2020) Bungwe la African Union - bungwe la kontinenti loimira mayiko 55 a mu Africa - lili ndi udindo waukulu kunyamula udindo umenewu." adatero Salim Abdul Karim.
Mliri wa COVID-19 ungathe kuthetsedwa kokha chifukwa cha mgwirizano wapadziko lonse komanso mgwirizano wachilungamo, a Sow adati. "Polimbana ndi matenda opatsirana padziko lonse lapansi, dziko silingakhale lokha - ngakhale kontinenti," adatero.
11/10/2021 Kufotokozera: Nkhani yoyambirira ya nkhaniyi inanena kuti pulogalamu ya ANTICOV idayendetsedwa ndi DNDi.M'malo mwake, DNDi ikugwirizana ndi ANTICOV, yomwe imayendetsedwa ndi ma 26 othandizana nawo.
Nthawi yotumiza: Apr-07-2022