Ma antibayotiki ambiri,Amoxicillin-clavulanate, ikhoza kupititsa patsogolo matumbo ang'onoang'ono mwa ana omwe ali ndi vuto la kuyenda, malinga ndi kafukufuku yemwe akupezeka mu June print edition ya Journal of Pediatric Gastroenterology and Nutrition kuchokera ku Nationalwide Children's Hospital.
Amoxicillan-clavulanate, yomwe imadziwikanso kuti Augmentin, imagwiritsidwa ntchito kwambiri pochiza kapena kupewa matenda omwe amayamba chifukwa cha mabakiteriya.Komabe, zanenedwanso kuti zimawonjezera kuyenda kwamatumbo ang'onoang'ono mwa anthu athanzi ndipo zakhala zikugwiritsidwa ntchito pochiza kuchuluka kwa mabakiteriya kwa odwala omwe akutsekula m'mimba kosatha.
Zizindikiro za m'mimba zam'mimba monga nseru, kusanza, kupweteka kwa m'mimba, kukhuta msanga komanso kutsekula m'mimba ndizofala kwa ana.Ngakhale kupita patsogolo kwaukadaulo wozindikira matenda oyenda motility, padakalibe kusowa kwa mankhwala ochizira matenda am'mimba am'mimba.
"Pali kufunikira kwakukulu kwa mankhwala atsopano kuti athetse zizindikiro zapamwamba za m'mimba mwa ana," anatero Carlo Di Lorenzo, MD, wamkulu wa Gastroenterology, Hepatology and Nutrition ku Nationalwide Children's Hospital ndi mmodzi mwa olemba maphunziro."Mankhwala omwe amagwiritsidwa ntchito pano nthawi zambiri amapezeka pokhapokha, amakhala ndi zotsatirapo zoyipa kapena sagwira ntchito mokwanira pamatumbo aang'ono ndi akulu."
Kuti awone ngati amoxicillin-clavulanate ingakhale njira yatsopano yochizira matenda a m'mimba, ofufuza a Nationwide Children's adafufuza odwala 20 omwe amayenera kukayezetsa atroduodenal manometry.Pambuyo poika catheter, gululo limayang'anira kuyenda kwa mwana aliyense panthawi yosala kudya kwa maola atatu.Anawo analandira mlingo umodzi waAmoxicillin-clavulanatem'matumbo, mwina ola limodzi musanadye kapena ola limodzi mutatha kudya, kenako ndikuwunikidwa kwa ola limodzi kutsatira.
Kafukufukuyu anasonyeza zimenezoAmoxicillin-clavulanateadayambitsa magulu a kufalikira kwamatumbo mkati mwa matumbo aang'ono, ofanana ndi omwe amawonedwa pagawo lachitatu la duodenal ya interdigestive motility process.Kuyankha uku kudachitika mwa ambiri mwa omwe adachita nawo phunzirolo mphindi 10-20 zoyambirira ndipo zidawonekera kwambiri atapatsidwa amoxicillin-clavulanate asanadye.
"Kuyambitsa gawo lachitatu la preprandial duodenal kumatha kufulumizitsa matumbo ang'onoang'ono, kukhudza matumbo a microbiome ndikuthandizira kupewa kukula kwa mabakiteriya ang'onoang'ono," adatero Dr. Di Lorenzo.
Dr. Di Lorenzo akunena kuti amoxicillin-clavulanate ikhoza kukhala yothandiza kwambiri kwa odwala omwe ali ndi kusintha kwa gawo lachitatu la duodenal, zizindikiro zosatha za kutsekeka kwa m'mimba komanso omwe amadyetsedwa mwachindunji m'matumbo aang'ono ndi machubu odyetsera a m'mimba kapena opaleshoni ya jejunostomy.
Ngakhale amoxicillin-clavulanate ikuwoneka kuti imakhudza kwambiri matumbo ang'onoang'ono, njira zomwe zimagwirira ntchito sizidziwika bwino.Dr. Di Lorenzo akunenanso kuti zovuta zogwiritsira ntchito amoxicillin-clavulanate monga prokinetic agent ndi kulowetsa kwa bakiteriya kukana, makamaka kuchokera ku mabakiteriya a gram-negative monga E. coli ndi Klebsiella ndikupangitsa kuti Clostridium difficile induced colitis.
Komabe, akuti kufufuza kwina kwaubwino wa amoxicillin-clavulanate munthawi yayitali m'matumbo am'mimba ndikofunikira."Kuchepa kwa njira zochizira zomwe zilipo pakadali pano kungavomereze kugwiritsa ntchito amoxicillin-clavulanate mwa odwala osankhidwa omwe ali ndi vuto lamatumbo ang'onoang'ono omwe njira zina sizinathandize," adatero.
Nthawi yotumiza: May-11-2022