News.pharmnet.com.cn 2021-11-25 China News Network
Pa Novembara 23, Chongqing GAOJIN Biotechnology Co., Ltd. (yomwe tsopano imadziwika kuti "GAOJIN biotechnology") ya m'chigawo cha Chongqing high tech Zone idalengeza kuti kutengera non radioactive isotope boron-10, idapanga bwino woyamba BPA boroni mankhwala zotupa zoipa monga khansa ya pakhungu, khansa ya muubongo ndi glioma, amene ankachitira ndi BNCT, ndicho boroni nyutroni adani mankhwala Mpaka mphindi 30 akhoza kuchiza zosiyanasiyana khansa yeniyeni.
BNCT ndi imodzi mwa njira zothandizira khansa padziko lonse lapansi.Imawononga maselo a khansa kudzera mu atomiki ya nyukiliya m'maselo otupa.Mfundo yake yochiritsira ndi: choyamba jekeseni boroni yopanda poizoni komanso yopanda vuto yomwe munali mankhwala mwa wodwalayo.Mankhwalawa akalowa m'thupi la munthu, amalunjika mwachangu ndikuunjikana m'maselo enaake a khansa.Panthawiyi, kuwala kwa neutron komwe kulibe kuwonongeka pang'ono kwa thupi la munthu kumagwiritsidwa ntchito poyatsa.Neutroni ikagundana ndi boron kulowa m'maselo a khansa, "nyukiliya" yamphamvu imapangidwa, kutulutsa ray yowopsa kwambiri ya ayoni.Mtundu wa ray ndi waufupi kwambiri, womwe ungathe kupha maselo a khansa popanda kuwononga minofu yozungulira.Ukadaulo wosankhidwa wa radiotherapy womwe umangopha maselo a khansa popanda kuwononga minyewa yabwinobwino amatchedwa boron neutron capture therapy.
Pakali pano, mankhwala a BPA boron okhala ndi GAOJIN biological code of "gjb01" amaliza kafukufuku wamankhwala a API ndi kukonzekera, ndipo amaliza kutsimikizira ndondomeko yokonzekera.Pambuyo pake, itha kugwiritsidwa ntchito m'mabungwe a R & D a BNCT neutron therapy zida ku China kuti achite kafukufuku wofunikira, kuyesa komanso kugwiritsa ntchito kuchipatala.Ndikoyenera kudziwa kuti kupanga woyendetsa ndi njira yofunikira yosinthira zopambana zasayansi ndiukadaulo kukhala mphamvu zogwira ntchito, ndipo kupambana kapena kulephera kwa chitukuko chazochita bwino kumatengera kupambana kapena kulephera kwa oyendetsa ndege.
Mu Marichi 2020, steboronine, chida choyamba cha BNCT padziko lonse lapansi komanso mankhwala oyamba a boron padziko lonse lapansi, adavomerezedwa kuti azitha kutsatsa ku Japan chifukwa cha khansa yapamutu komanso yapakhosi yosasinthika.Kuphatikiza apo, mazana amayesero azachipatala achitidwa mu zotupa muubongo, khansa ya khansa ya m'mapapo, khansa ya m'mapapo, pleural mesothelioma, khansa ya chiwindi, ndi khansa ya m'mawere, ndipo zidziwitso zochiritsira zapezeka.
Cai Shaohui, wachiwiri kwa manejala wamkulu komanso mtsogoleri wa polojekiti ya GAOJIN biology, adati index yonse ya "gjb01" imagwirizana kwathunthu ndi mankhwala a steboronine omwe adalembedwa ku Japan, ndipo mtengo wake ndiwokwera kwambiri.Akuyembekezeka kugwiritsidwa ntchito kuchipatala mu 2023 ndipo akuyembekezeka kukhala mankhwala oyamba kutchulidwa a BNCT anti-cancer boron ku China.
Cai Shaohui adati, "mkhalidwe wapamwamba wa chithandizo cha BNCT ndi wosakayikitsa.Pachimake ndi mankhwala boron.Cholinga cha biology yapamwamba ya Jin ndikupangitsa kuti chithandizo cha BNCT cha China chifike pamlingo wotsogola padziko lonse lapansi.Mtengo wa chithandizo ukhoza kuyendetsedwa bwino pafupifupi yuan 100,000, kuti odwala khansa athe kulandira chithandizo chamankhwala komanso kukhala ndi ndalama zochiritsira.
"Thandizo la BNCT limatha kutchedwa 'ngale pa korona' ya chithandizo cha khansa chifukwa cha mtengo wake wotsika, chithandizo chachifupi (mphindi 30-60 nthawi iliyonse, chithandizo chachangu kwambiri chimatha kuchiritsidwa kamodzi kapena kawiri), zisonyezo zazikulu komanso zotsika. zotsatira zake."Wang Jian, CEO wa GAOJIN biology, adati chinsinsi chofunikira kwambiri ndikutsata ndikukonzekera mankhwala a boron, Imatsimikizira ngati chithandizocho chingathe kuchiza mitundu yambiri ya khansa.
Nthawi yotumiza: Nov-25-2021