Makanda ndi ana a miyezi 9 mpaka zaka 4 omwe ali ndi vuto la kuchepa kwa magazi m'thupi anali ndi kuwonjezeka kwakukulu kwa hemoglobini ndi ferrous sulfate kusiyana ndi iron-polysaccharide complexes pa masabata a 12, malinga ndi kafukufuku wachipatala wopangidwa mwachisawawa wofalitsidwa mu JAMA.Chachikulu.
Kuperewera kwa magazi m'thupi mwa makanda ndi ana aang'ono - makamaka chifukwa chomwa mkaka wa ng'ombe mopitirira muyeso kapena kuyamwitsa kwa nthawi yayitali popanda chitsulo chokwanira - kunakhudza anthu oposa 1 biliyoni padziko lonse lapansi mu 2010, 3% mwa iwo anali ana azaka 1 mpaka 2 ku America. .Nthawi zambiri zimachitika mwa ana omwe akukula mofulumira ndipo angayambitse kupsa mtima, malaise, pica, ndi matenda a neurodevelopmental aifupi ndi aatali.
Ferrous sulphate, mchere wachitsulo, ndiwo mankhwala ochizira matenda a kuchepa kwa magazi m'thupi.
"Kulephera kwa mankhwala kumakhala kofala chifukwa cha mankhwala osagwiritsa ntchito mankhwala, zotsatirapo zoipa zomwe zimagwirizanitsidwa ndi kuwonjezereka, komanso kusowa kwa malangizo oyendetsera umboni," anatero Jacquelyn M. Powers, MD, MS, School of Medicine, Baylor Assistant Professor of Pediatrics and Hematology. /Oncology, ndi anzawo adalemba."Mayesero ochepa chabe azachipatala amadziwitsa kusankha kwa chitsulo, kuchuluka kwa mlingo, ndi nthawi ya chithandizo, mosasamala kanthu za chiyambi, zaka, kapena kugonana kwa anthu omwe akhudzidwa."
Akuluakulu ndi anzawo adayesa ma iron-polysaccharide complexes mu makanda 80 ndi ana a miyezi 9 mpaka 48 (zaka zapakatikati, miyezi 22; 55% amuna; 61% white Hispanic) okhala ndi chitsulo chosowa magazi m'thupi.ferrous sulphatekuti muwonjezere kuchuluka kwa hemoglobin.
Pakati pa September 2013 ndi November 2015, ochita kafukufuku anapatsa ana kuti alandire 3 mg / kg yachitsulo kamodzi patsiku ngati madontho a ferrous sulfate (n = 40) kapena iron-polysaccharide complex drops (n = 40) = 40) kwa masabata a 12. .
Makolo kapena osamalira analangizidwa kuti azipereka mlingo wa tsiku ndi tsiku pogona, kupewa kusakaniza mlingo ndi chakudya kapena zakumwa zilizonse, komanso kupewa mkaka kwa ola la 1 pambuyo poyendetsa mankhwala ophunzirira. 600 ml tsiku lililonse.
Kusintha kwa hemoglobini pa masabata a 12 kunagwiritsidwa ntchito ngati mapeto oyambirira.Mapeto achiwiri anaphatikizapo kuthetsa kwathunthu kwa kuchepa kwachitsulo m'magazi, kusintha kwa seramu ferritin ndi mphamvu zonse zomangira chitsulo, ndi zotsatira zake zoipa.
Anthu makumi asanu ndi anayi mphambu asanu ndi anayi adamaliza mayeserowo, 28 kuchokera ku gulu la ferrous sulfate ndi 31 kuchokera ku gulu la iron-polysaccharide complex.
Kuyambira pachiyambi mpaka sabata la 12, hemoglobini imachokera ku 7.9 g/dL kufika 11.9 g/dL mu ferrous sulfate gulu ndi kuchokera 7.7 g/dL kufika 11.1 g/dL mu gulu la iron-polysaccharide complex, kusiyana kwakukulu kwa 1 g / dL (95% CI, 0.4-1.6; P <.001) ndi ferrous sulfate.
Poyerekeza ndi gulu la chitsulo cha polysaccharide, makanda ndi ana omwe ali m'gulu la ferrous sulfate anali ndi ziwopsezo zapamwamba za kukhululukidwa kwathunthu kwa kuchepa kwa magazi m'thupi (29% vs 6%; P = .04) . 15.6 ng / mL mu gulu la ferrous sulfate ndi kuchokera ku 2 ng / mL mpaka 7.5 ng / mL mu gulu la iron-polysaccharide complex, ndi kusiyana kwakukulu kwa 10.2 ng / mL (95 ng / mL).% CI, 6.2-14.1;P <.001) ndi ferrous sulfate.
Kuchuluka kwachitsulo kumangiriza kutsika kuchokera ku 501 µg/dL kufika ku 389 µg/dL, pamene ferrous sulfate inatsika kuchokera ku 506 μg/dL kufika ku 417 µg/dL, ndipo chitsulo-polysaccharide chovuta chinali -50 µg/dC (95%). , -86 mpaka -14; P <.001) ndi ferrous sulfate.
Kutsekula m'mimba kunali kofala kwambiri ndi iron-polysaccharide complexes kusiyana ndi ferrous sulfate (58% vs 35%; P = .04).
Ofufuzawo adawona kuti 50 peresenti ya makolo ndi osamalira adanenanso kuti akuvutika kuwongolera zovuta za iron-polysaccharide, poyerekeza ndi 65 peresenti ya gulu la ferrous sulfate.
Zochepa za kafukufukuyu zinaphatikizapo kuti zinachitikira ku chipatala cha ana a maphunziro apamwamba ndipo anali ndi chiwerengero chochepa cha odwala omwe ali ndi ndalama zochepa komanso ochepa omwe ali ndi vuto la kuchepa kwa magazi m'thupi, pafupifupi 23% mwa iwo ankafuna kuikidwa magazi asanalembetsedwe.
"Zotsatirazi ziyenera kuthandizira kupititsa patsogolo mayesero azachipatala kuti awonenso mlingo wocheperako kapena wocheperako wachitsulo chapakamwa," a Powers ndi anzake adalemba." Zotsatira zoyembekezeka zingaphatikizepo kutsata bwino kwa odwala komanso kuyamwa kwachitsulo, zomwe zimapangitsa kuti pakhale kuyankha bwino kwa hematologic."- Chuck Gormley
Kuwulura: Gensavis Pharmaceuticals ndi omwe adapereka ndalama pa kafukufukuyu.Ofufuzawo akuti palibe zowulula zofunikira pazachuma.
Nthawi yotumiza: Mar-21-2022