Kugwiritsa ntchito ma multivitamin pakati pa azaka zapakati, amuna okalamba kumabweretsa kuchepa pang'ono kwa khansa, kafukufuku amapeza

“Multivitaminsndizowonjezera zakudya zowonjezera, zomwe zimatengedwa nthawi zonse ndi gawo limodzi mwa magawo atatu a akuluakulu aku US.Ntchito yachikhalidwe ya multivitamin tsiku lililonse ndikupewa kuperewera kwa zakudya.Kuphatikizika kwa mavitamini ndi michere yofunika yomwe ili mu ma multivitamini kumatha kuwonetsa zakudya zopatsa thanzi monga kudya zipatso ndi ndiwo zamasamba, zomwe zakhala zikukhudzidwa modzichepetsa komanso mosagwirizana ndi chiopsezo cha khansa m'maphunziro ena, koma osati onse.Maphunziro owonetsetsa akugwiritsa ntchito ma multivitamin kwa nthawi yayitali komanso kumapeto kwa khansa kwakhala kosagwirizana.Pakalipano, mayesero akuluakulu osasinthika omwe amayesa mavitamini ndi mchere wambiri pamtundu umodzi kapena wochepa kwambiri wa khansa nthawi zambiri apeza kuti alibe mphamvu, "adatero kumbuyo kwa magazini."Ngakhale kusowa kwa chidziwitso chotsimikizika chokhudza ubwino wamultivitaminspopewa matenda aakulu, kuphatikizapo khansa, amuna ndi akazi ambiri amawatenga pachifukwa chimenechi.”

J. Michael Gaziano, MD, MPH, wa Brigham and Women Hospital ndi Harvard Medical School, Boston, (komanso Contributing Editor,JAMA), ndi anzake adasanthula deta kuchokera ku Physicians 'Health Study (PHS) II, kuyesa kokha kwakukulu, kosasintha, kopanda khungu, koyang'aniridwa ndi placebo komwe kumayesa zotsatira za nthawi yaitali za multivitamin wamba popewa matenda aakulu.Kuyesaku kudayitanitsa madotolo achimuna a 14,641 aku US azaka zopitilira 50, kuphatikiza amuna 1,312 omwe ali ndi khansa pambiri yawo yachipatala.Iwo adalembedwa mu phunziro la multivitamin lomwe linayamba mu 1997 ndi chithandizo ndikutsatira mpaka June 1, 2011. Ophunzira adalandira multivitamin tsiku lililonse kapena placebo yofanana.Chotsatira chachikulu cha kafukufukuyu chinali khansa yathunthu (kupatulapo khansa yapakhungu ya nonmelanoma), yokhala ndi khansa ya prostate, colorectal, ndi khansa ina yapamalo omwe ali pakati pazigawo zomaliza.

Ophunzira a PHS II adatsatiridwa kwa zaka pafupifupi 11.2.Pa chithandizo cha multivitamin, panali milandu 2,669 yotsimikizika ya khansa, kuphatikiza milandu 1,373 ya khansa ya prostate ndi 210 ya khansa ya colorectal, pomwe amuna ena adakumana ndi zochitika zingapo.Amuna onse a 2,757 (18.8 peresenti) adamwalira panthawi yotsatila, kuphatikizapo 859 (5.9 peresenti) chifukwa cha khansa.Kuwunika kwa datayo kunawonetsa kuti amuna omwe amamwa ma multivitamin adachepetsa pang'ono 8 peresenti ya chiwerengero chonse cha khansa.Amuna omwe amamwa ma multivitamin adachepetsanso khansa yamtundu wa epithelial cell.Pafupifupi theka la khansa zonse zomwe zimachitika ndi khansa ya prostate, ambiri mwa iwo anali atangoyamba kumene.Ofufuzawo sanapeze zotsatira za multivitamin pa khansa ya prostate, pomwe ma multivitamin amachepetsa kwambiri chiopsezo cha khansa yathunthu kupatula khansa ya prostate.Panalibe kuchepetsedwa kwakukulu kwapang'onopang'ono kwa khansa yapayekha, kuphatikiza khansa ya colorectal, mapapo, ndi chikhodzodzo, kapena kufa kwa khansa.

Kugwiritsa ntchito ma multivitamin tsiku lililonse kumalumikizidwanso ndi kuchepa kwa khansa yathunthu pakati pa amuna a 1,312 omwe ali ndi mbiri yoyambira ya khansa, koma izi sizinasiyane kwambiri ndi zomwe zidawonedwa pakati pa amuna a 13,329 poyamba opanda khansa.

Ofufuzawo adawona kuti kuchuluka kwa khansa pakuyesa kwawo kudakhudzidwa ndi kuchuluka kwa kuwunika kwa prostate-specific antigen (PSA) komanso kupezeka kwa khansa ya prostate pakutsata kwa PHS II kuyambira kumapeto kwa zaka za m'ma 1990."Pafupifupi theka la khansa zonse zomwe zatsimikiziridwa mu PHS II zinali khansa ya prostate, yomwe ambiri analipo kale, khansa ya prostate yotsika yomwe imakhala ndi moyo wambiri.Kuchepetsa kwakukulu kwa khansa yonse yochotsa khansa ya prostate kukuwonetsa kuti kugwiritsa ntchito ma multivitamin tsiku lililonse kumatha kukhala ndi phindu lalikulu pakuzindikira matenda a khansa. "

Olembawo akuwonjezera kuti ngakhale mavitamini ndi michere yambiri yomwe ili mu kafukufuku wa PHS II wa multivitamin adalemba maudindo a chemopreventive, ndizovuta kudziwa mwatsatanetsatane njira iliyonse yomwe ingathandizire kuti munthu kapena magawo angapo a ma multivitamin awo oyesedwa achepetse chiopsezo cha khansa."Kuchepa kwa chiwopsezo cha khansa mu PHS II akuti kuphatikiza kwakukulu kwa mavitamini ndi michere yocheperako yomwe ili mu PHS II multivitamin, m'malo motsindika pamayesero amtundu wapamwamba wamankhwala omwe adayesedwa kale, kungakhale kofunika kwambiri popewa khansa. .…

"Ngakhale kuti chifukwa chachikulu chotengera ma multivitamini ndikupewa kuperewera kwa zakudya m'thupi, izi zimapereka chithandizo chothandizira kugwiritsa ntchito ma multivitamini popewa khansa kwa amuna azaka zapakati ndi akulu," ofufuzawo adamaliza.