Kafukufuku wapeza kuti amoxicillin wapakamwa ndi wotetezeka komanso wogwira ntchito kwa amayi apakati omwe sakugwirizana ndi penicillin

Canada: Azimayi apakati, omwe anali ndi mbiri yakale ya penicillin sagwirizana ndi zinthu zina zomwe ankatha kukwanitsa kumwa molunjikaamoxicillinzovuta popanda kufunikira koyezetsa khungu m'mbuyomu, inatero nkhani yomwe idasindikizidwa muThe Journal of Allergy and Clinical Immunology: Mukuchita.

M'magulu osiyanasiyana odwala, penicillin allergy de-labeling apezeka kuti ndi otetezeka komanso opambana mwa anthu omwe ali pachiwopsezo chochepa.Mayeso akuwonetsa kuti anthu opitilira 90% sakhala ndi matupi awo poyamba.Ngakhale kuti kutenga pakati sikuwonjezera chiopsezo cha penicillin ziwengo, amayi oyembekezera nthawi zambiri amachotsedwa kafukufuku wambiri.Kafukufukuyu adachitidwa ndi Raymond Mak ndi gulu pachitetezo chaAmoxicillinmwa amayi apakati.

Pakati pa Julayi 2019 ndi Seputembala 2021, asing'anga pachipatala cha BC Women's Hospital ndi Health Center adapereka zovuta zapakamwa kwa amayi oyembekezera 207 azaka zapakati pa 28 ndi 36 milungu yoyembekezera.Chifukwa amayiwa onse anali ndi PEN-FAST ya 0, chida chotsimikizirika, chothandizira chithandizo chamankhwala cha penicillin chomwe chimayembekezera mwayi woyezetsa khungu, onsewo anali pachiwopsezo chochepa kwambiri.Amayi awa adawonedwa kwa ola limodzi atatha kumwa 500 mgamoxicillinpakamwa.Madokotala adatenga zizindikiro zawo zoyambirira, mphindi 15 pambuyo pake, ndi ola limodzi pambuyo pake.Odwala omwe sanawonetse zizindikiro za mayankho a IgE-mediated adachotsedwa ndi malangizo oti alankhule ndi chipatala ngati akuda nkhawa ndi kuchedwa.

Zotsatira zazikulu za kafukufukuyu zinali motere:

1. Panalibe hypersensitivity yachangu kapena yochedwa mu 203 mwa anthuwa.

2. Odwala anayi otsala (1.93%) anali ndi zotupa za benign maculopapular, zomwe zinachitidwa ndi betamethasone valerate 0.1% mafuta ndi antihistamines.

3. Kuyankha kwa 1.93% kunali kofanana ndi chiwerengero cha 1.99% chomwe chinanenedwa kale mwa anthu akuluakulu omwe sali oyembekezera komanso 2.5% mwa omwe ali ndi pakati.

4. Panalibe anthu omwe amafunikira epinephrine kapena anaphylaxis, ndipo palibe amene adaloledwa kuchipatala chifukwa cha kuyezetsa.

Pomaliza, malinga ndi ochita kafukufuku, kuchepetsa kufunikira koyezetsa khungu la penicillin kungachepetse mtengo wa reagent, nthawi yachipatala, komanso kufunikira koyendera akatswiri ang'onoang'ono, zomwe zingalimbikitse chisamaliro cha odwala panthawi yobereka komanso yobereka.Kuti mupeze umboni wamphamvu, kufufuza kwina kwakukulu kumafunika.

ref:Mak, R., Zhang, BY, Paquette, V., Erdle, SC, Van Schalkwyk, JE, Wong, T., Watt, M., & Elwood, C. (2022).Chitetezo cha Direct Oral Challenge kwa Amoxicillin mwa Odwala Oyembekezera pachipatala cha Canada Tertiary Hospital.Mu Journal of Allergy and Clinical Immunology: Mukuchita.Elsevier BV.