Sodium ya Chloramphenicolni ifu yera cyangwa umuhondo-yera ya hygroscopique.1,4 g ya monografiya ihwanye na 1 g ya chloramphenicol.
Kwirinda
Chtoramphenicot irwanya-abarwayi bafite amateka ya hyperensitivite cyangwa uburozi bwibiyobyabwenge.Ntigomba na rimwe guhabwa gahunda yo kwandura kworoheje cyangwa kuri prophylaxis.ubuyobozi bujyanye na chtoramphenicot hamwe nindi miti ishobora kugabanya amagufwa-marrow funetion igomba kwirindwa.Kugabanya gufunga bigomba guhabwa abarwayi bafite imikorere yumwijima.Chloramphemcol irashobora kubangamira iterambere ryubudahangarwa kandi ntigomba gutangwa mugihe cyo gukingira gukomeye.
Imikoranire
Chloramphenicol ihindurwa mu mwijima bityo rero, irashobora gukorana n'imiti ikoreshwa na enzymes ya microsomal.Kurugero, chloramphenicol yongerera imbaraga antikagulant ya coumarm nka dicoumarol na sodium ya warfarin, hypoglycemic nka chlorpropamide na tolbutamide, hamwe na antepiteptike nka fenytoin, kandi bishobora kugabanya metabolisme ya cuctophosphamufe.Ibinyuranye na metabolism ya chloramphemcol irashobora kongerwa na mducers ya enzymes ya hepatike nka phenobarbitone cyangwa nfampicin.Ibisubizo bivuguruzanya byavuzwe hamwe na parasetamol na phenytoin.Chloramphenicol irashobora kugabanya ingaruka za fer na vitamine Bi2 kubarwayi badafite amaraso kandi bikabangamira imikorere yo kuboneza urubyaro.
Igikorwa cyo kurwanya mikorobe
Chloramphe.
Imikoreshereze n'Ubuyobozi
V Inshingano, ya chloranphenicol itera ubuzima-bwangiza ingaruka mbi cyane cyane amagufwa-mar-umurongo aplasia,.yagabanije cyane akamaro kayo kamavuriro, nubwo iracyakoreshwa cyane mubihugu bimwe.Ntigomba na rimwe kuba giyen kuri gahunda, kuko kwandura kworoheje no kubara amaraso bisanzwe mubisanzwe mugihe cyo kuvura.Igisekuru cya gatatu cephalosporine ubu itoneshwa kuri byinshi byabanje kwerekana chlorampheniclo.Hano haribintu bike bidasobanutse byerekana gukoresha chloramphenicol.Yakoreshejwe muri tifoyide ikabije nizindi ndwara za salmonellal, nubwo idakuraho leta yinjiza.Chloramphenicol ni ubundi buryo bwa cephalosporine yo mu gisekuru cya gatatu mu kuvura meningite ya bagiteri, haba mu buryo bworoshye ndetse no kurwanya ibinyabuzima byoroshye nka Haemophtlus tnfluenzae.Yakoreshejwe mu kuvura indwara zikomeye za anaerobic, mu buryo bwihariye mu ibisebe byo mu bwonko, no mu ndwara ziri munsi ya diafragma aho Bacteroides fragitis ikunze kuba;icyakora, ubundi biyobyabwenge bikunzwe.Nubwo tetracycline ikomeza kuvura ot kwandura indwara ya tifusi na s, ibibyimba byanduye, chforamphenicol nayo ikoreshwa nkubundi buryo tetracycline, idashobora gutangwa.
Izindi ndwara ziterwa na bagiteri aho chloramphenicol ishobora gukoreshwa nk'indi miti irimo antarakera, kwandura indwara zikomeye hamwe n'inda ya Campylobacter, ehrlichiose, gastro-ententis, gas gangrene, granuloma inguinale, kwandura ibicurane bya Haemophitus uretse meningite (urugero nko muri meningite). epiglottitis), listeriyose, metioidose ikabije, icyorezo (cyane cyane iyo meningite ikuze), psittacose, tularaemia (especial [y iyo meningite ikekwa), n'indwara ya Whipple.Kuri, ibisobanuro birambuye kuri ziriya ndwara no kuvura ..
Chioramphenicol ikoreshwa cyane mubuvuzi bwibanze, bwamatwi na m, cyane cyane kwandura amaso, nubwo ibyinshi muribi byoroheje kandi byigenga.Irakoreshwa kandi cyane m kuvura indwara ya skm.Dose igaragazwa m mvugo ya chloramphenicol base kandi irasa niyo yatanzwe numunwa cyangwa imitsi.Kubantu bakuru nabana, ikinini gisanzwe ni 5O mg kuri kg uburemere bwumubiri burimunsi mubice bigabanijwe buri masaha 6;kugeza kuri mg 100 kuri kg buri munsi birashobora guhabwa m meningite cyangwa kwandura gukabije bitewe n’ibinyabuzima birwanya ubukana, nubwo iyi dosiye yo hejuru igomba kugabanuka vuba bishoboka.Kugirango ugabanye nsk yo kwisubiramo byasabwe ko ubuvuzi bugomba kwanduzwa nyuma yubushyuhe bwumurwayi bumaze gusubira muminsi yindi minsi 4 m nckettsial no muminsi 8 kugeza 10 mumyanya ya tifoyide.
Ahatariho ubundi buryo bwo gukoresha çhloramphenicol, imburagihe na tern yuzuye, neonates irashobora gutanga dosiye ya buri munsi ya 25 mg kuri kg-uburemere bwumubiri hamwe nimpinja zuzuye zirengeje ibyumweru 2, ay gutangwa kugeza kuri mg 50 kuri kg buri munsi, m 4 igabanijwe: Gukuramo plasma yibyingenzi ni ngombwa kugirango wirinde uburozi.
Ku barwayi bafite ubumuga bwa he.imikorere ya patique cyangwa impyiko zikomeye zidakabije urugero rwa chloramphenicol rushobora gukenera kubisubiramo kubera kugabanuka kwimisemburo cyangwa gusohoka.
Mu kuvura indwara zamaso chloramphenicol ikoreshwa nkigisubizo cya 0.5% cyangwa nkamavuta ya 1%.
Ingaruka mbi
Chloramphemcol irashobora gutera ingaruka zikomeye kandi rimwe na rimwe zica.Bimwe muburozi bwabyo bikekwa ko biterwa n'ingaruka za synthesis ya mitochondnal.Ingaruka mbi cyane ya chloramphemcol ni ihungabana ryayo igufwa, rishobora gufata uburyo 2 butandukanye.Iya mbere ni ikinini gikunze kugaragara kijyanye no kwiheba bibaho mubisanzwe iyo plasma-chloramphenicol yibanda kuri 25 ug permL kandi ikarangwa na morphologie m igufwa ryamagufwa, kugabanuka kwicyuma, reticulocylopenia anemia, leucopenia na trombocytopenia.Izi ngaruka zishobora guterwa no kubuza intungamubiri za poroteyine muri mitochomária ya selile marrow selile.anaphylaxis yabayeho ariko ni gake, reaction ya Jansch-Herxheimer nayo ishobora kubaho.Ibimenyetso bya gastrointestinal harimo isesemi, kuruka, no gucibwamo birashobora gukurikiza ubuyobozi bwo munwa.Guhungabana kw'ibimera byo mu kanwa no mu mara, bishobora gutera stomatite, glossite, hamwe no kurwara urukiramende, abarwayi barashobora kugira uburyohe bukaze nyuma yubuyobozi bwihuse bwimitsi ya chororamphenicot sodium.
Kurenza urugero
Byaragaragaye ko amakara yamakara aruta kure cyane guhinduranya amaraso mu kuvanaho amaraso ya chloramphenicol, nubwo byabujije urupfu mafant wibyumweru 7 hamwe na syndrome yumwana wumukara nyuma yikosa ryambukiranya.
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