[Incamake]
Artemisinin (QHS) ni igitabo cyitwa sesquiterpene lactone kirimo ikiraro cya peroxy gitandukanijwe nubuvuzi bwibimera bwubushinwa Artemisia annua L. Artemisinin ifite imiterere yihariye, ikora neza kandi ifite uburozi buke.Ifite anti-tumor, anti-tumor, anti-bacterial, anti-malariya, hamwe ningaruka zongera imiti.Ifite ingaruka zidasanzwe muburyo bwo gukoresha ubwonko no guhohotera nabi.Nibiyobyabwenge byonyine bizwi ku rwego mpuzamahanga byo kurwanya malariya mu Bushinwa.Yabaye imiti myiza yo kuvura malariya isabwa n’umuryango w’ubuzima ku isi.
[Imiterere yumubiri nubumashini]
Artemisinin ni urushinge rutagira ibara rufite ibara rya 156 ~ 157 ° C. Rishobora gushonga byoroshye muri chloroform, acetone, Ethyl acetate na benzene.Irashobora gushonga muri Ethanol, ether, gushonga gato muri peteroli ikonje, kandi hafi yo kudashonga mumazi.Kubera itsinda ryayo ryihariye rya peroxy, ntirishobora gushyuha kandi ryangirika byoroshye bitewe nubushuhe, bushyushye kandi bugabanya ibintu.
[Ibikorwa bya farumasi]
1. Ingaruka zo kurwanya malariya Artemisinin ifite imiti yihariye ya farumasi kandi ifite ingaruka nziza zo kuvura malariya.Mubikorwa bya antimalarial artemisinin, artemisinin itera gusenyuka burundu imiterere yinzoka ibangamira imikorere ya membrane-mitochondrial ya malariya parasite.Isesengura ryibanze ryiki gikorwa ni ubu buryo bukurikira: itsinda rya peroxy mumiterere ya molekuline ya artemisinin itanga radicals yubusa ikoresheje okiside, kandi radicals yubuntu ihuza na poroteyine ya malariya, bityo igakora ku miterere ya membrane ya protozoa, ikangiza membrane, ibisasu bya kirimbuzi na plasma membrane.Mitochondriya yarabyimbye kandi imbere n'inyuma biratandukana, amaherezo bisenya imiterere ya selile n'imikorere ya parasite ya malariya.Muri ubu buryo, chromosomes muri nucleus ya malariya parasite nayo yibasiwe.Ubushakashatsi bwa optique na electronique bwerekana ko artemisinin ishobora kwinjira muburyo bwimiterere ya Plasmodium, ishobora guhagarika neza intungamubiri zitangwa na Plasmodium iterwa na selile itukura, bityo bikabangamira imikorere ya membrane-mitochondrial ya Plasmodium (Aho guhungabanya imikorere yayo folate metabolism, amaherezo itera gusenyuka burundu parasite ya malariya.Gukoresha artemisinin bigabanya kandi cyane urugero rwa isoleucine yatewe na Plasmodium, bityo bikabuza guhuza poroteyine muri Plasmodium.
Byongeye kandi, ingaruka ziterwa na artemisinine nazo zijyanye n'umuvuduko wa ogisijeni, kandi umuvuduko mwinshi wa ogisijeni uzagabanya ubukana bwa artemisinine kuri P. falciparum ikomoka muri vitro.Kurimbuka kwa malariya na artemisinin bigabanijwemo ubwoko bubiri, bumwe ni ugusenya byimazeyo malariya;ikindi nukwangiza selile yamaraso itukura ya malariya, biganisha ku rupfu rwa malariya.Ingaruka ya antimalarial ya artemisinin igira ingaruka itaziguye kuri erythrocyte ya Plasmodium.Nta ngaruka zingenzi zigaragara mbere na erythrocytike.Bitandukanye nizindi antimalariyale, uburyo bwa antimalarial artemisinin bushingira cyane cyane kuri peroxyl mumiterere ya molekuline ya artemisinin.Kubaho kwa peroxyl bigira uruhare rukomeye mubikorwa bya antimalarial artemisinin.Niba nta tsinda rya peroxide, artemisinin izabura ibikorwa bya antimalarial.Kubwibyo, birashobora kuvugwa ko uburyo bwa antimalarial artemisinin bufitanye isano rya hafi no kwangirika kwamatsinda ya peroxyl.Usibye ingaruka nziza yo kwica kuri malariya, artemisinin igira n'ingaruka zimwe na zimwe zo kubuza izindi parasite.
2. Ingaruka zo kurwanya ibibyimba Artemisinin igira ingaruka zigaragara zo gukura kw'ingirabuzimafatizo zitandukanye nka kanseri y'umwijima, kanseri y'ibere na kanseri y'inkondo y'umura.Ubushakashatsi butari buke bwerekanye ko artemisinin ifite uburyo bumwe bwo kurwanya malariya na antikanseri, aribyo kurwanya malariya na anti-kanseri ikorwa na radicals yubuntu iterwa no kumena ikiraro cya peroxy mumiterere ya molekuline ya artemisinin.Kandi inkomoko imwe ya artemisinin iratoranya kubuza ubwoko butandukanye bwibibyimba.Igikorwa cya artemisinin kuri selile yibibyimba gishingiye ku kwinjiza selile apoptose kugirango irangize kwica selile.Muri izo ngaruka zimwe na zimwe, dihydroartemisinin ibuza gukora hypoxia itera ibintu byongera itsinda rya ogisijeni ikora.Kurugero, nyuma yo gukora kuri selile ya selile ya leukemia, artemisinin irashobora kongera intungamubiri ya calcium yo mu nda ihindura uburyo bwimikorere ya selile yayo, idakora gusa Calpain mungirangingo ya leukemia, ahubwo inateza imbere kurekura ibintu bya apoptotique.Wihutishe inzira ya apoptose.
3. Ingaruka zo gukingira Artemisinin igira ingaruka kumikorere yubudahangarwa.Ukurikije ko urugero rwa artemisinin n'ibiyikomokaho bidatera cytotoxicity, artemisinin irashobora kubuza lymphocyte mitogen T neza, bityo bikaba bishobora gutuma lymphocytes ziyongera mu mbeba.Artesunate irashobora kongera ibikorwa byuzuzanya bya serumu yimbeba mukuzamura ingaruka zubudahangarwa budasanzwe.Dihydroartemisinin irashobora kubuza mu buryo butaziguye ikwirakwizwa rya lymphocytes B no kugabanya ururenda rwa autoantibodies na lymphocytes B, bityo bikabuza ubudahangarwa bw'umubiri.
4. Igikorwa cyo kurwanya antifungal Igikorwa cya antifungal ya artemisinin kigaragarira mukubuza ibihumyo.Ifu ya Artemisinin na decoction igira ingaruka zikomeye zo kubuza epidermidis ya Staphylococcus, antacracis ya Bacillus, diphtheria na catarrhalis, kandi ikagira n'ingaruka zimwe na zimwe kuri Pseudomonas aeruginosa, Shigella, Mycobacterium igituntu na Staphylococcus aureus.Kubuzwa.
5. Anti-Pneumocystis carinii pneumonia ingaruka Artemisinin isenya cyane cyane imiterere ya sisitemu ya Pneumocystis carinii membrane, itera vacuole muri cytoplazme na pack ya sporozoite trophozoite, mitochondria kubyimba, guturika kwa kirimbuzi hamwe no gusenya ibibazo bya endoplasmic. impinduka zubaka.
6. Ingaruka zo kurwanya inda Imiti ya Artemisinin ifite ubumara bwo guhitamo insoro.Igipimo cyo hasi kirashobora gutuma insoro zipfa no gukuramo inda.Irashobora gutezwa imbere nk'imiti ikuramo inda.
7. Anti-Schistosomiasis Itsinda rikora anti-schistosomiasis ni ikiraro cya peroxy, kandi uburyo bwacyo bwo kuvura ni ukugira ingaruka ku isukari ya metabolisme yinyo.
8. Ingaruka z'umutima-Artemisinin zirashobora gukumira cyane aritthmia iterwa no guhuza imiyoboro y'amaraso, ishobora gutinza cyane itangira rya arththmia iterwa na calcium chloride na chloroform, kandi bikagabanya cyane fibrillation ya ventricular.
9. Kurwanya fibrosis Bifitanye isano no guhagarika ikwirakwizwa rya fibroblast, kugabanya synthesis ya kolagen, hamwe no kwangirika kwa anti-histamine.
10. Izindi ngaruka Dihydroartemisinin igira ingaruka zikomeye zo kubuza Leishmania donovani kandi ifitanye isano na dose.Artemisia annua ikuramo nayo yica Trichomonas vaginalis na lysate amoeba trophozoites.
Igihe cyo kohereza: Nyakanga-19-2019