Impinja n’abana kuva ku mezi 9 kugeza ku myaka 4 bafite ikibazo cyo kubura intungamubiri za fer nke zidafite ubwiyongere bukabije bwa hémoglobine hamwe na sulfate ferrous ugereranije n’ibyuma bya polysaccharide mu byumweru 12, nkuko byagaragajwe n’ikigereranyo cy’amavuriro cyashyizwe ahagaragara muri JAMA.Kinini.
Amaraso make yo kubura fer ku bana bato ndetse nabana bato - bikunze guterwa no kunywa cyane amata yinka cyangwa konsa igihe kirekire nta byuma byongeweho neza - byibasiye abantu barenga miliyari 1 kwisi yose muri 2010, 3% muribo bari bafite hagati yimyaka 1 na 2 muri Amerika .Bisanzwe bibaho mubana bakura vuba kandi birashobora gutera uburakari, kurwara, pica, hamwe nigihe gito kandi kirekire.
Sulfate ya ferrous, umunyu w'icyuma, nubuvuzi busanzwe bwo kubura intungamubiri zidafite intungamubiri.Nyamara, uruganda rwicyuma-polysaccharide rurimo fer fer (NovaFerrum, Pharmaceuticals ya Gensavis) rushobora gukoreshwa mubindi kuko bishobora guteza imbere kwihanganira uburyohe.
Jacquelyn M. Powers, MD, MS, Ishuri ry'Ubuvuzi, Umuyobozi wungirije wa Baylor ushinzwe ubuvuzi bw'abana na Hematology, yagize ati: "Kunanirwa kwivuza ni ibisanzwe bitewe n'imiti itayubahiriza, ingaruka mbi ziterwa no kunywa birenze urugero, ndetse no kutagira umurongo ngenderwaho wo kuyobora." / Oncology, na bagenzi be baranditse. ”Ibigeragezo bike byateganijwe byerekana ko umuntu atoranya ibyuma, uburyo bwo gufata imiti, ndetse n'igihe cyo kwivuza, hatitawe ku miterere ya etiologiya, imyaka, cyangwa igitsina cy'abantu bafite ingaruka.”
Imbaraga na bagenzi be basuzumye ibyuma-polysaccharide yibice 80 byabana bato n’amezi 9 kugeza 48 (imyaka yo hagati, amezi 22; 55% byigitsina gabo; 61% byera Hispanic) hamwe na anemia yo kubura intungamubiri Ese birakora neza kurutasulfate ferrouskongera ingufu za hemoglobine.
Hagati ya Nzeri 2013 na Ugushyingo 2015, abashakashatsi batanze ku bushake abana kwakira mg / kg 3 z'icyuma cy'ibanze rimwe na rimwe nk'ibitonyanga bya ferrous sulfate (n = 40) cyangwa ibyuma bya polysaccharide bigabanuka (n = 40) = 40) mu byumweru 12 .
Ababyeyi cyangwa abarezi basabwe gutanga ikinini cya buri munsi mugihe cyo kuryama, kwirinda kuvanga ikinini nibiryo cyangwa ibinyobwa, no kwirinda amata mugihe cyisaha 1 nyuma yubuyobozi bwibiyobyabwenge. Abashakashatsi kandi basaba ko ababyeyi nabarezi bagabanya amata kugeza a ntarengwa ya 600ml kumunsi.
Guhindura hemoglobine mubyumweru 12 byabaye iherezo ryibanze.Icyiciro cya kabiri cyarimo gukemura byuzuye kubura amaraso make, impinduka za serumu ferritine hamwe nubushobozi bwo guhuza ibyuma, hamwe ningaruka mbi.
Abitabiriye 59 barangije igeragezwa, 28 bo mu itsinda rya sulfate ferrous na 31 bo mu itsinda ry’icyuma-polysaccharide.
Kuva kuri baseline kugeza icyumweru cya 12, bivuze ko hemoglobine yiyongereye kuva kuri 7.9 g / dL igera kuri 11,9 g / dL mumatsinda ya sulfate ferrous no kuva 7.7 g / dL ikagera kuri 11.1 g / dL mumatsinda yibyuma bya polysaccharide, itandukaniro rinini rya 1 g / dL (95% CI, 0.4-1.6; P <.001) hamwe na sulfate ferrous.
Ugereranije nitsinda ryicyuma cyitwa polysaccharide, impinja nabana bo mumatsinda ya ferrous sulfate bari bafite igipimo kinini cyo gukuraho burundu kubura amaraso make (29% vs 6%; P = .04) .Urwego rwa serumu ferritine rwiyongereye kuva kuri 3 ng / mL kugeza 15,6 ng / mL mu itsinda rya sulfate ferrous no kuva kuri 2 ng / mL kugeza kuri 7.5 ng / mL mu itsinda rya fer-polysaccharide, hamwe n’itandukaniro rinini rya 10.2 ng / mL (95 ng / mL).% CI, 6.2-14.1;P <.001) hamwe na sulfate ferrous.
Ubushobozi rusange bwo guhuza ibyuma bwagabanutse kuva kuri 501 µg / dL bugera kuri 389 µg / dL, mugihe sulfate ferrous yagabanutse ikava kuri 506 µg / dL ikagera kuri 417 µg / dL, naho icyuma-polysaccharide cyari –50 µg / dL (95% CI , –86 kugeza –14; P <.001) na sulfate ferrous.
Indwara y'impiswi yari ikunze kugaragara hamwe na fer-polysaccharide kuruta sulfate ferrous (58% vs 35%; P = .04).
Abashakashatsi bavuze ko 50 ku ijana by'ababyeyi n'abarezi bavuze ko bigoye gucunga uruganda rukora fer-polysaccharide, ugereranije na 65 ku ijana by'itsinda rya sulfate ferrous.
Intambamyi z’ubushakashatsi zirimo ko zakorewe mu bitaro byita ku bana bo mu cyiciro cya gatatu kandi zikaba zifite umubare utagereranywa w’abarwayi bafite amikoro make ndetse n’abarwayi bake bafite ikibazo cyo kubura amaraso make, hafi 23% muri bo bakaba bakeneye guterwa amaraso mbere yo kwiyandikisha.
Powers na bagenzi be baranditse bati: "Ibi bisubizo bigomba gufasha kwihutisha ibizamini byo kwa muganga kugira ngo hamenyekane urugero rwa fer yo mu kanwa cyangwa nkeya cyane."- Chuck Gormley
Kumenyekanisha: Pharmaceuticals ya Gensavis yateye inkunga ubu bushakashatsi. Abashakashatsi bavuga ko nta mpapuro zerekana imari.
Igihe cyo kohereza: Werurwe-21-2022