Ubushakashatsi busanga amoxicillin yo mu kanwa itekanye kandi ifite akamaro kubagore batwite allergique kuri penisiline

Kanada: Abagore batwite, bafite amateka ya allergie ya penisiline bashoboye kurangiza neza umunwaamoxicilliningingo idakenewe kwipimisha mbere yuruhu, nkuko ingingo yasohotse muriIkinyamakuru cya Allergie na Immunology Clinical: Mubikorwa.

Mubantu batandukanye barwayi, penisiline allergie de-label yasanze ifite umutekano kandi igenda neza kubantu bafite ibyago bike.Kwipimisha byerekana ko abantu barenga 90% atari allergiki.Nubwo gutwita bitongera ibyago bya allergie ya penisiline, abagore batwite usanga akenshi mubushakashatsi bwinshi.Ubu bushakashatsi bwakozwe na Raymond Mak hamwe nitsinda ryumutekano waAmoxicillinku bagore batwite.

Hagati ya Nyakanga 2019 na Nzeri 2021, abaganga bo mu bitaro by’abagore n’ikigo nderabuzima cya BC bahaye ibibazo bitaziguye ku bagore 207 batwite bafite hagati y’ibyumweru 28 na 36 batwite.Kuberako aba badamu bose bari bafite amanota ya PEN-FAST ya 0, yemejwe, point-of-care-penisilline allergie igikoresho cyo kuvura giteganya ko bishoboka kwipimisha uruhu rwiza, bose basanze bafite ibyago bike cyane.Aba badamu bagaragaye isaha imwe nyuma yo gufata 500 mg yaamoxicillinmu kanwa.Abaganga bavura ibimenyetso byabo byingenzi mugitangira, nyuma yiminota 15, nisaha imwe.Abarwayi batagaragaje ibimenyetso byerekana ibisubizo bya IgE bahujwe birukanwe n'amabwiriza yo kuvugana n’ivuriro niba bafite impungenge zo gutinda.

Iby'ingenzi byagaragaye muri ubu bushakashatsi byari ibi bikurikira:

1. Ntabwo hypersensitivite yahise cyangwa yatinze muri 203 muri aba bantu.

2. Abarwayi bane basigaye (1.93%) barwaye maculopapular rashes, bavuwe na betamethasone valerate 0.1% amavuta na antihistamine.

3. Igipimo cya 1.93% cyagereranijwe nikigereranyo cya 1.99% mubantu bakuze badatwite naho 2,5% mubantu batwite.

4. Nta bantu basabaga epinephrine cyangwa barwaye anaphylaxis, kandi nta numwe winjiye mubitaro bivuye kwipimisha.

Mu gusoza, nk'uko abashakashatsi babitangaza, kugabanya ibisabwa mu gupima uruhu rwa penisiline byagabanya ibiciro bya reagent, igihe cy’ivuriro, ndetse no gukenera gusura inzobere zidasanzwe, ibyo byose bikaba byazamura ubuvuzi bw’abarwayi mu gihe cyo kubyara no kubyara.Kubindi bimenyetso bifatika, birakenewe ko hakorwa iperereza rinini.

ref:Mak, R., Zhang, BY, Paquette, V., Erdle, SC, Van Schalkwyk, JE, Wong, T., Watt, M., & Elwood, C. (2022).Umutekano wibibazo byo munwa kuri Amoxicillin mubarwayi batwite mubitaro bya Tertiary byo muri Kanada.Mu Kinyamakuru cya Allergie na Immunology Clinical: Mubikorwa.Elsevier BV.