Chloramphenicol Sodium Succinateupfu chena kana yero-chena hygroscopic.1.4 g yezvinhu zvemonograph inenge yakaenzana ne1 g yechloramphenicol.
Precaution
Chtoramphenicot inopesana-inoratidzirwa kune varwere vane nhoroondo ye hypersensitivity kana chepfu maitiro kumushonga.Izvo hazvifanirwe kupihwa systemicity kune diki hutachiona kana yeprophylaxis.kupindirana kwekutonga kwechtoramphenicot nemamwe madhiragi anokodzera kushungurudza mapfupa-mwongo mafiro anofanira kudziviswa.Kuvhara kwakaderedzwa kunofanirwa kupihwa kune varwere vane kusagadzikana kwechiropa basa.Chloramphemcol inogona kukanganisa kukura kwekudzivirira uye haifanirwe kupihwa panguva yekudzivirira inoshanda.
Kudyidzana
Chloramphenicol inogadzirwa muchiropa uye inogona, naizvozvo, kupindirana nemishonga inogadziriswa nehepatic microsomal enzymes.Semuenzaniso, chloramphenicol inowedzera migumisiro ye coumarm anticoagulants yakadai se dicoumarol uye warfarin sodium, imwe hypoglycemic yakadai se chlorpropamide uye tolbutamide, uye antiepiteptics yakadai se phenytoin, uye inogona kuderedza metabolism ye cuctophosphamufe kune iyo inoshanda fomu.Sezvineiwo, metabolism yechloramphemcol inogona kuwanda nevanogadzira maenzayimu ehepatic akadai se phenobarbitone kana nfampicin.Kupokana mhedzisiro yakataurwa neparacetamol uye phenytoin.Chloramphenicol inogona kuderedza mhedzisiro yesimbi uye vhitamini Bi2 muvarwere vane anemia uye kukanganisa mashandiro emishonga yekudzivirira nemuromo.
Antimicrobial Action
Chloramphe.nicol is g bacteriostatic antibiotic witi yakafara spektimu yechiito inorwisa ese mabhakitiriya eGram-posi-tive neGram-negative, pamwe chete nezvimwe zvipenyu.
Zvishandiso uye Kutungamira
V Mhosva, yekloranphenicol kukonzeresa mhedzisiro inotyisidzira hupenyu, kunyanya bone-mar-row aplasia,.yakaganhurira zvakanyanya kubatsira kwayo kuchipatara, kunyangwe ichiri kushandiswa zvakanyanya mune dzimwe nyika.Haifanire kunge iri giyen systemically, nekuti hutachiona hudiki uye huwandu hweropa hunowanzo kurudzirwa panguva yekurapa.Yechitatu-chizvarwa cephalosporins ikozvino yafarirwa kune akawanda ekare anoratidza chlorampheniclo.Naizvozvo, pane zvishoma zviratidzo zvisina kujeka zvekushandiswa kwechloramphenicol.Yakashandiswa muhutu hwakanyanya hwetyphoid uye zvimwe zvirwere zve salmonella, kunyange zvazvo zvisingabvisi hurumende yekuwana.Chloramphenicol ndiyo imwe nzira kune yechitatu-chizvarwa cephalosporin mukurapwa kwebhakitiriya meningitis, zvese epirirically uye nekurwisa tupukanana senge Haemophtlus tnfluenzae.Yakashandiswa mukurapa zvirwere zvakanyanya anaerobic, patricularly muuropi abscesses, uye mune zvirwere pasi pe diaphragm apo Bacteroides fragitis inowanzobatanidzwa;zvisinei, mimwe mishonga inowanzofarirwa.Kunyange zvazvo tetracyclines inoramba iri kurapwa kwechisarudzo muhosha dze rickettsial dzakadai setyphus uye s,potted fevers, chforamphenicol inoshandiswawo seimwe nzira iyo tetracyclines, haigone kupiwa.
Zvimwe zvirwere zvebhakitiriya umo chloramphenicol inogona kushandiswa seimwe nzira kune mamwe madhiragi zvinosanganisira anthrax, zvakanyanya systemic zvirwere neCampylobacter fetus, ehrlichiosis, gastro-ententis, , gas gangrene, granuloma inguinale, zvirwere zvakanyanya Haemophitus influenzae kunze kwe meningitis (semuenzaniso epiglottitis), listeriosis, metioidosis yakakomba, denda (kunyanya kana meningitis ikakura), psittacosis, tularaemia (kunyanya[y apo meningitis inofungidzirwa), uye chirwere cheWhipple.Nekuti, ruzivo rwezvirwere izvi uye kurapwa kwavo..
Chioramphenicol inoshandiswa zvakanyanya mukurapa kwemusoro, kwezeve uye, kunyanya, maziso emeso, zvisinei nekuti mazhinji aya akapfava uye selflimitmg.Inoshandiswawo pamusoro m kurapwa kwe skm zvirwere.Madhosi anotaridzwa m mazwi echloramphenicol base uye akafanana angave achipihwa nemuromo kana mutsinga.Kune vakuru nevana, iyo yakajairika dose i5O mg pakg yehuremu hwemuviri zuva nezuva muzvikamu zvakakamurwa maawa matanhatu ega ega;kusvika ku 100 mg pakg zuva rega rega inogona kupiwa m meningitis kana zvirwere zvakakomba nekuda kwezvipenyu zvine mwero, kunyange zvazvo mishonga iyi yakakwirira inofanira kuderedzwa nokukurumidza sezvinobvira.Kuti uderedze nsk yekudzoka zvakare, zvakakurudzirwa kuti kurapwa kuitwe mushure mekunge tembiricha yemurwere yadzokera kune yakajairika kune mamwe mazuva mana m nckettsial zvirwere uye kwemazuva 8 kusvika gumi mune lever yetyphoid.
Kana pasina imwe nzira yekushandiswa kwe çhloramphenicol, nguva isati yakwana uye yakazara-tern, vechidiki vanogona kupiwa madosi ezuva nezuva e25 mg pakg yehuremu hwemuviri uye vacheche venguva yakazara vanopfuura zera remavhiki maviri, vanogona kupihwa kusvika ku50 mg. pakg zuva nezuva, m 4 akakamurwa madosi: Momtoring yeplasma concentrations kwakakosha kuti, udzivise chepfu.
Mune varwere vakaremara he.patic function kana yakanyanya renal inipainnent muyero wechloramphenicol ungangoda kuderedzwa nekuda kwekuderera kwechimelabolism kana kubuda.
Mukurapa kwemaziso chloramphenicol inowanzoiswa se 0.5% solution kana se 1% yekuzora.
Migumisiro Yakashata
Chloramphemcol inogona kukonzera zvakakomba uye dzimwe nguva zvinouraya zvakaipa.Humwe hwehupfu hwayo hunofungidzirwa kuve nekuda kwemhedzisiro pamitochondnal protein synthesis.Iyo yakanyanya senous yakaipa mhedzisiro ye chloramphemcol kuderera kwayo kwemwongo, iyo inogona kutora maviri akasiyana mafomu.Yokutanga ndeyekuora mwoyo kunowanzoitika kana plasma-chloramphenicol inopfuura 25 ug permL uye inoratidzirwa ne morphological chaps m mwongo, kuderera kwesimbi kushandiswa, reticulocylopenia anemia, leukopenia uye thrombocytopenia.Mhedzisiro iyi inogona kunge yakakonzerwa nekudziviswa kweprotein synthesis mumitochomária yemasero emapfupa., Hypersensitivity reactions mctuding rashes, fever, uye angioedema inogona kuitika kunyanya mushure mekushandiswa kwemusoro;anaphylaxis yakaitika asi isingawanzoitiki, Jansch-Herxheimer-senge maitiro anogona kuitika.Zviratidzo zvemudumbu zvinosanganisira kuda kurutsa, kurutsa, uye manyoka zvinogona kutevedzera kubatwa nemuromo.Kuvhiringidzwa kwemaruva emukanwa uye emudumbu, zvinogona kukonzera stomatitis, glossitis, uye rectal irntation, Varwere vanogona kunzwa kuravira kwakanyanya kunotevera kukurumidza kurongerwa kwechloramphenicot sodium succinate.
Overdosage
Charcoal haemoperfusion yakawanikwa ikanyanya kukunda kuisirwa ropa muremval ye chloramphenicol form blood, kunyangwe yakadzivirira kufa ma 7-week-old mfant ane grey baby syndrome zvichitevera kukanganisa kwecrosage.
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