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Kweanopfuura gore, Adeola Fowotade anga achiedza kuunganidza vanhu kuti vaedze kurapwa kweCCIDID-19. Sechiremba wehutachiona hwehutachiona paUniversity College Hospital, Ibadan, Nigeria, akapinda mukuedza muna Nyamavhuvhu 2020 kuyedza kushanda kwe-off- Chinangwa chake ndechekutsvaga vanozvipira makumi mashanu - vanhu vakawanikwa vaine COVID-19 vane zviratidzo zviri pakati nepakati uye vangangobatsirikana neiyo cocktail yemishonga. muna January naFebruary. Pashure pemwedzi misere, akanga apinza basa vanhu 44 chete.
"Vamwe varwere vakaramba kutora chikamu muchidzidzo pavakasvika, uye vamwe vakabvuma kumira pakati pekutongwa," akadaro Fowotade.Kamwe nyaya yacho yakatanga kudonha muna March, zvakanga zvisingakwanisi kuwana vatori vechikamu.Izvo zvakaita kuti kutongwa, kuzivikanwe, kunozivikanwa. seNACOVID, yakaoma kupedzisa."Hatina kukwanisa kuzadzisa saizi yedu yatakaronga," akadaro. Mhosva yakapera munaGunyana uye yakatadza kusvika payanga yakananga kupinza vanhu basa.
Matambudziko aFowotade anoratidza matambudziko akatarisana nemimwe miedzo muAfrica - dambudziko guru kune nyika dziri mukondinendi iyo isingakwanise kuwana mishonga yekudzivirira yeCCIDID-19. vanobaiwa nhomba. Izvi zviri pasi zvishoma paavhareji yenyika dzine hupfumi hwepasi. Zvinofungidzirwa kuti nyika dzemuAfrica hadzizove nemishonga yakakwana yekubaya 70% yehuwandu hwevanhu vekondinendi kusvika munaGunyana 2022.
Izvi zvinosiya nzira shoma dzekurwisa denda pari zvino.Kunyangwe mishonga yakadai semonoclonal antibodies kana antiviral drug remdesivir yakashandiswa munyika dzakapfuma dziri kunze kweAfrica, mishonga iyi inofanirwa kupihwa muzvipatara uye inodhura.Mushonga mukuru wemishonga Merck akabvuma rezinesi repiritsi-based drug molnupiravir kune vagadziri kwarinogona kushandiswa zvakanyanya, asi mibvunzo inoramba yekuti ichaita marii kana ikabvumidzwa. Nekuda kweizvozvo, Africa iri kuwana mishonga isingadhuri, inowanikwa zviri nyore inogona kuderedza zviratidzo zveCOVID-19, kuderedza kuremerwa kwechirwere pahurongwa hwehutano, uye kuderedza kufa.
Kutsvaga uku kwakasangana nezvipingamupinyi zvakawanda. Pamiyedzo ingangosvika zviuru zviviri iri kuongorora kurapwa kwemishonga yeCCIDID-19, vangangosvika zana nemakumi mashanu chete vakanyoreswa muAfrica, ruzhinji muEgypt neSouth Africa, sekureva kwekiriniki.gov, dhatabhesi inotungamirwa neUnited. States.Kushaikwa kwemiedzo idambudziko, anodaro Adeniyi Olagunju, chiremba wezvemishonga paUniversity yeLiverpool kuUK uye NACOVID lead research zvishoma, akadaro. "Wedzerai pakuwanikwa kwakadzikira kwemishonga," Oragonju akadaro.
Mamwe masangano ari kuyedza kugadzirisa kushomeka uku.ANTICOV, chirongwa chinofambiswa nesangano reDrugs for Neglected Diseases Initiative (DNDi), pari zvino ndicho chiyedzo chikuru muAfrica. Imwe ongororo inonzi Repurposing Anti-Infectives yeCOVID-19 Therapy (ReACT) - yakarongwa nesangano risingabatsiri reMedicines for Malaria Venture - ichaedza kuchengetedzwa uye kushanda kwemishonga yekudzorerazve mishonga muSouth Africa. yezvivakwa, uye kuomerwa mukutora vatori vechikamu muyedzo zvipingamupinyi zvikuru kune izvi kuedza.
"MuAfrica kumaodzanyemba kweSahara, hutano hwedu hwehutano hwakaputsika," akadaro Samba Sow, muongorori wenyika yose paANTICOV muMali.Izvo zvinoita kuti miedzo yakaoma, asi inonyanya kukosha, kunyanya pakuziva mishonga inogona kubatsira vanhu mukutanga kwechirwere. uye kudzivirira kupinda muchipatara. Kwaari nevamwe vakawanda vari kudzidza nezvechirwere ichi, mujaho wekurwisa rufu.” Hatingamirire kusvika murwere arwara zvakaipisisa,” akadaro.
Denda reCoronavirus rawedzera tsvakiridzo yekiriniki mukondinendi yeAfrica. Nyanzvi yeVaccinologist Duduzile Ndwandwe anoteedzera tsvakiridzo yekurapa kwekuyedza kuCochrane South Africa, chikamu chesangano repasi rose rinoongorora humbowo hwehutano, ndokuti Pan-African Clinical Trials Registry yakanyoresa 606 miedzo yekiriniki muna 2020. , zvichienzaniswa ne2019 408 (ona 'Clinical trials in Africa').Pakazosvika Nyamavhuvhu gore rino, yakanga yanyoresa miedzo 271, kusanganisira yekudzivirira zvirwere nemishonga.Ndwandwe akati: "Takaona miedzo yakawanda ichiwedzera huwandu hweCOVID-19."
Nekudaro, miyedzo yekurapa coronavirus ichiri kushaikwa. Muna Kurume 2020, World Health Organisation (WHO) yakatanga mureza wayo weSolidarity Trial, ongororo yepasi rose yezvina zvinogona kurapwa zveCOVID-19. Nyika mbiri chete dzemuAfrica dzakapinda muchikamu chekutanga chekudzidza. .Dambudziko rekuendesa hutano kuvarwere vari kurwara zvakanyanya raita kuti nyika zhinji dzisabatana, akadaro Quarraisha Abdool Karim, chiremba wezvirwere zvezvirwere paColumbia University muNew York City, muDurban, South Africa. akadaro, asi zvinotanga danho rekuedzwa kwakawanda kwekurapwa kweCCIDID-19. Muna Nyamavhuvhu, World Health Organisation yakazivisa chikamu chinotevera cheyedzo yekubatana, iyo ichaedza mimwe mishonga mitatu. Dzimwe nyika shanu dzemuAfrica dzakatora chikamu.
Muyedzo weNACOVID wakaitwa naFowotade une chinangwa chekuyedza kurapa kwemusanganiswa pavanhu makumi mapfumbamwe nevasere muIbadan nedzimwe nzvimbo nhatu muNigeria. Vanhu vari muongororo iyi vakapihwa mishonga yema antiretroviral atazanavir ne ritonavir, pamwe nemushonga weantiparasitic unonzi nitazoxanide.Kunyangwe chinangwa chekunyoresa chaive zvisati zvasangana, Olagunju akati timu iri kugadzirira chinyorwa kuti chibudiswe uye inotarisira kuti data ichapa mamwe manzwisisiro ekushanda kwemushonga.
Muedzo weSouth Africa ReACT, unotsigirwa muSeoul nekambani yemishonga yekuSouth Korea yeShin Poong Pharmaceutical, une chinangwa chekuedza misanganiswa yemishonga mina yakadzokororwa zvakare: mishonga yekurwisa marariya atesunate-amodiaquine uye pyrrolidine-artesunate;Favipiravir, mushonga wefuruwenza unoshandiswa musanganiswa ne nitre;uye sofosbuvir uye daclatasvir, mushonga unorwisa utachiona unowanzoshandiswa kurapa hepatitis C.
Kushandisa mishonga yakadzorerwa kunokwezva zvikuru kuvatsvakurudzi vakawanda nokuti inogona kunge iri nzira inogoneka yekukurumidza kutsvaga marapirwo anogona kuparadzirwa zviri nyore.Kushaikwa kweAfrica kwezvivakwa zvekutsvaga zvinodhaka, kusimudzira nekugadzira kunoreva kuti nyika hadzigone kuedza nyore makomboni matsva nemishonga inogadzirwa nevakawanda. .Kuedza ikoko kwakakosha, anodaro Nadia Sam-Agudu, nyanzvi yezvirwere zvinotapukira zvevana paUniversity yeMaryland anoshanda paNigeria Institute of Human Virology muAbuja.” Kana zvikabudirira, marapiro aya anogona kudzivirira kurwara kwakakomba uye kuiswa muchipatara, uyewo pamwe [mira] kuenderera mberi nekutapurirana," akawedzera.
Muyedzo mukuru wekondinendi, ANTICOV, yakatangwa munaGunyana 2020 paine tarisiro yekuti kurapwa kwekutanga kunogona kudzivirira COVID-19 kubva mukuremedza hutano hwehutano hweAfrica. Parizvino iri kutora vanhu vanopfuura mazana mashanu munzvimbo gumi neina muDemocratic Republic of Congo, Burkina. Faso, Guinea, Mali, Ghana, Kenya neMozambique ine chinangwa chekupinza vanhu zviuru zvitatu munyika gumi nenhatu.
Mushandi pamakuva muDakar, Senegal, muna Nyamavhuvhu sechikamu chechitatu chehutachiona hweCCIDID-19 chakarova.Mufananidzo wechikwereti: John Wessels/AFP/Getty
ANTICOV iri kuedza kushanda kwemishonga miviri yakasanganiswa yakave nemigumisiro yakasanganiswa kune imwe nzvimbo.Yekutanga inosanganisa nitazoxanide neine inhaled ciclesonide, corticosteroid inoshandiswa kurapa asima.Yechipiri inosanganisa artesunate-amodiaquine ne antiparasitic drug ivermectin.
Kushandiswa kweivermectin mukurapa kwezvipfuyo uye kurapwa kwezvimwe zvisina kutarisirwa zvirwere zvinopisa muvanhu kwakonzera gakava munyika dzakawanda. iyo data inotsigira kushandiswa kwayo ine mubvunzo.MuEgypt, chidzidzo chikuru chinotsigira kushandiswa kweivermectin muCOVID-19 varwere chakabviswa nepreprint server mushure mekunge yaburitswa pakati pekupomerwa kusarongeka kwedata uye kuba.(Vanyori vechidzidzo ichi vanopokana kuti vabudisi havana kuvapa mukana wekuzvidzivirira.) Ongororo ichangobva kuitika yeCochrane Infectious Diseases Group yakawana humbowo hunotsigira kushandiswa kweivermectin mukurapa hutachiona hweCOVID-19 (M. Popp et al. Cochrane Database Syst. Rev. 7, CD015017; 2021).
Nathalie Strub-Wourgaft, anomhanyisa chirongwa cheDDi's COVID-19, akati pane chikonzero chiri pamutemo chekuyedza mushonga uyu muAfrica. yakawanikwa ichishaikwa, DNDi yakagadzirira kuedza mimwe mishonga.
"Nyaya yeivermectin yakaitwa zvematongerwo enyika," akadaro Salim Abdool Karim, chiremba wechirwere chechirwere uye director weDurban-based Center for AIDS Research muSouth Africa (CAPRISA)." , zvino ipfungwa yakanaka.”
Kubva pane data iripo kusvika nhasi, kusanganiswa kwe nitazoxanide uye ciclesonide kunoratidzika kuvimbisa, Strub-Wourgaft akati. -Wourgaft akati ANTICOV iri kugadzirira kuyedza ruoko rutsva uye icharamba ichishandisa maoko maviri aripo ekurapa.
Kutanga kuyedza kwaive kwakaoma, kunyangwe kuDNDi ine ruzivo rwakakura rwebasa mukondinendi yeAfrica.Kubvumidzwa kwemutemo idambudziko guru, akadaro Strub-Wourgaft. Naizvozvo, ANTICOV, yakabatana neWHO's African Vaccine Regulatory Forum (AVAREF), yakamisa dambudziko nzira yekuita ongororo yakabatana yezvidzidzo zvekiriniki munyika dze13. Izvi zvinogona kukurumidza kubvumidzwa kwemitemo uye tsika. "Inotibvumira kuunza pamwe chete nyika, vatungamiri uye nhengo dzebhodhi rekuongorora maitiro," akadaro Strub-Wourgaft.
Nick White, nyanzvi yemushonga wekupisa anosachigaro weCCIDID-19 Clinical Research Consortium, mubatanidzwa wepasi rose kutsvaga mhinduro kuCCIDID-19 munyika dzine mari yakaderera, akataura kuti kunyangwe danho reWHO raive rakanaka, Asi zvinotora nguva yakareba kuti uwane mvumo. , uye tsvakurudzo munyika dzine mari yakaderera uye yepakati zviri nani pane tsvakurudzo munyika dzakapfuma.Zvikonzero zvinosanganisira mitemo yakasimba yekutonga munyika idzi, pamwe chete nemasimba asina kunaka pakuita kuongorora kwehutsika nekugadzirisa.Izvo zvinofanira kuchinja, White akati.
Asi matambudziko haagumire ipapo. Kana kutongwa kwatanga, kushaikwa kwezvinhu uye magetsi zvinogona kukanganisa kufambira mberi, akadaro Fowotade. Akachengeta masampuli eCCIDID-19 mufiriji -20 °C panguva yekudzima kwemagetsi muchipatara cheIbadan. inodawo kutakura masampuli kuenda kuEd Center, kwemaawa maviri nekutyaira, kuti aongororwe.
Olagunju akawedzera kuti dzimwe nyika padzakamira kupa mari nzvimbo dzekuzviparadzanisa nevamwe dzeCCIDID-19 muzvipatara zvavo, kutora vatori vechikamu mukutongwa kwakawedzera kunetsa. Pasina zviwanikwa izvi, varwere chete vanokwanisa kubhadhara ndivo vanobvumidzwa. mari yekuzviparadzanisa nevamwe uye nzvimbo dzekurapa.Hapana aitarisira kuvhiringwa,” akadaro Olagunju.
Kunyangwe iine zviwanikwa zvakanaka, zviri pachena kuti Nigeria haisi kutora chikamu muANTICOV. ”Munhu wese ari kunzvenga miedzo yekiriniki muNigeria nekuti isu hatina sangano,” akadaro Oyewale Tomori, chiremba wehutachiona uye sachigaro weNigeria's COVID-19 Ministerial Advisory. Komiti yeNyanzvi, inoshanda kuona mazano anoshanda uye maitiro akanakisa ekubata neCOVID-19.
Babatunde Salako, mutungamiriri weNigerian Institute of Medical Research muLagos, haabvumirani nazvo.Salako akati Nigeria ine ruzivo rwekuita ongororo dzekiriniki, pamwe nekutora vanhu muchipatara uye komiti ine simba yekuongorora tsika inoronga kubvumidzwa kwemiedzo yekiriniki muNigeria. mazwi ezvivakwa, hongu, anogona kunge asina simba;ichiri kukwanisa kutsigira miedzo yekiriniki,” akadaro.
Ndwandwe anoda kukurudzira vatsvakurudzi vakawanda vemuAfrica kuti vapinde muzviedzo zvekiriniki kuitira kuti vagari vemo vawane mikana yakaenzana yekurapa kunovimbisa.Kuedza kwemuno kunogona kubatsira vatsvakurudzi kuona marapirwo anobatsira.Vanogona kugadzirisa zvinodikanwa munzvimbo dzisina zviwanikwa uye kubatsira kuvandudza hutano, anodaro Hellen Mnjalla. , maneja emiedzo yekiriniki yeWellcome Trust Research Program paKenya Institute of Medical Research muKilifi.
"COVID-19 chirwere chitsva chinotapukira, saka tinoda miedzo yekiriniki kuti tinzwisise kuti mapindiro aya achashanda sei muvanhu vemuAfrica," Ndwandwe akawedzera.
Salim Abdul Karim vanotarisira kuti dambudziko iri richakurudzira masayendisiti emuAfrica kuti vavake pane zvimwe zvivakwa zvekutsvagisa zvakavakwa kurwisa denda reHIV/AIDS.” Dzimwe nyika dzakaita seKenya, Uganda neSouth Africa dzine zvivakwa zvakasimukira.Asi kune dzimwe nzvimbo hadzina kubudirira,” vakadaro.
Kuwedzera miedzo yekiriniki yeCCIDID-19 kurapwa muAfrica, Salim Abdool Karim anokurudzira kuumbwa kwesangano rakadai seConsortium for Clinical Trials yeCOVID-19 Vaccines (CONCVACT; yakagadzirwa neAfrican Centers for Disease Control and Prevention muna Chikunguru 2020) Sangano reAfrican Union - dare rekondinendi rinomirira nyika makumi mashanu neshanu dzenhengo dzeAfrica - rakagadzwa kuti ritakure basa iri." akadaro Salim Abdul Karim.
Denda reCCIDID-19 rinogona chete kukundwa kuburikidza nekudyidzana nedzimwe nyika uye kudyidzana kwakanaka, Sow akadaro.
11/10/2021 Tsanangudzo: Imwe vhezheni yekutanga yechinyorwa ichi yakataura kuti chirongwa cheANTICOV chaifambiswa neDNDi.
Nguva yekutumira: Kubvumbi-07-2022