Iyo inowanzo antibiotic,amoxicillin-clavulanate, inogona kuvandudza ura hudiki muvana vari kusangana nekukanganisika kwekufamba, maererano neongororo inobuda muChikumi chakadhindwa edition ye Journal of Pediatric Gastroenterology and Nutrition kubva kuNationalwide Children's Hospital.
Amoxicillan-clavulanate, inozivikanwawo seAugmentin, inonyanya kunyorerwa kurapa kana kudzivirira kutapukira kunokonzerwa nemabhakitiriya.Nekudaro, yakanzi zvakare inowedzera diki bowel motility muvanhu vane hutano uye yakashandiswa kurapa kuwedzera kwebhakitiriya muvarwere vane manyoka asingaperi.
Zviratidzo zvepamusoro zvegumbo zvakadai sekusvotwa, kurutsa, kurwadziwa mudumbu, kutanga kuguta uye kutsemuka kwedumbu zvinowanzoitika muvana.Zvisinei nekufambira mberi muhunyanzvi hwekuongorora kusagadzikana kwekufamba, kunoramba kuine kushomeka kwemishonga inowanikwa yekurapa kwepamusoro gastrointestinal tract motor basa.
"Pane kudiwa kwakakosha kwemishonga mitsva yekurapa zviratidzo zvepamusoro zvegumbo muvana," akadaro Carlo Di Lorenzo, MD, mukuru weGastroenterology, Hepatology uye Nutrition paNationalwide Children's Hospital uye mumwe wevanyori vekudzidza."Mishonga inoshandiswa pari zvino inowanzowanikwa chete payakaganhurirwa, ine mhedzisiro yakakura kana isingashande zvakakwana paura diki nehukuru."
Kuti vaongorore kana amoxicillin-clavulanate ingashanda sechisarudzo chitsva chekurapa chepamusoro chegomarara remudumbu, vaongorori vepaNyika Yese Vana vakaongorora varwere makumi maviri vakarongerwa kuongororwa antroduodenal manometry.Mushure mekuisa catheter, timu yakaongorora mafambiro emwana wega wega panguva yekutsanya kweanenge maawa matatu.Vana vakabva vapihwa imwe dose yeamoxicillin-clavulanatemukati, ingave awa imwe chete isati yadya kana awa imwe mushure mekudya uyezve motility inotariswa kweawa imwe inotevera.
Chidzidzo chacho chakaratidza izvozvoamoxicillin-clavulanateyakakonzera mapoka ezvibvumirano zvakapararira mukati memukati mudiki, zvakafanana neaya akaonekwa panguva yeduodenal phase III ye interdigestive motility process.Mhinduro iyi yakaitika muvazhinji vevatori vechikamu muchidzidzo mukati memaminitsi gumi kusvika makumi maviri ekutanga uye yainyanya kuoneka apo amoxicillin-clavulanate yakapihwa vasati vadya.
"Inducing preprandial duodenal phase III inogona kukurumidza kufamba kwemukati, kukanganisa gut microbiome uye kuita basa rekudzivirira kukura kwehutachiwana huduku hwebhakitiriya," akadaro Dr. Di Lorenzo.
Dr. Di Lorenzo anoti amoxicillin-clavulanate inogona kunyanya kushanda kune varwere vane shanduko ye duodenal phase III, zvisingaperi zviratidzo zvemukati pseudo-kuvharidzirwa uye avo vanodyiswa zvakananga mudumbu duku ne gastrojejunal nasojejunal feeding tubes kana jejunostomy yekuvhiya.
Kunyangwe amoxicillin-clavulanate ichiita seinonyanyo kanganisa ura hudiki, maitiro ayo ainoshanda nawo haana kujeka.Dr. Di Lorenzo anotaurawo kuti zvinobvira pasi pekushandisa amoxicillin-clavulanate seprokinetic agent zvinosanganisira kuiswa kwebhakitiriya rekudzivirira, kunyanya kubva ku gram-negative mabhakitiriya akadai seE. coli neKlebsiella uye kukonzera Clostridium difficile induced colitis.
Zvakadaro, anoti kumwe kuferefetwa kweamoxicillin-clavulanate yenguva refu mabhenefiti mune gastrointestinal kiriniki mamiriro akakosha."Kushomeka kwemaitiro ekurapa aripo iye zvino kunogona kupembedza kushandiswa kweamoxicillin-clavulanate muvarwere vakasarudzwa vane mafomu akakomba ediki dysmotility mune mamwe mapindiro asina kushanda," akadaro.
Nguva yekutumira: May-11-2022