News.pharmnet.com.cn 2021-11-25 China News Network
Musi wa23 Mbudzi, Chongqing GAOJIN Biotechnology Co., Ltd. (yakazonzi “GAOJIN biotechnology”) yeNational Biological industry base yeChongqing high tech Zone yakazivisa kuti zvichibva pane isiri radioactive isotope boron-10, yakanga yabudirira kugadzira yekutanga BPA boron mushonga wemamota akashata senge melanoma, kenza yeuropi uye glioma, iyo yakarapwa neBNCT, inova boron neutron capture therapy Kusvika maminitsi makumi matatu inogona kurapa akasiyana siyana egomarara.
BNCT ndiyo imwe yenzira dzepamusoro-soro dzekurapa cancer munyika.Inoparadza maseru egomarara kuburikidza neatomu yenyukireya kuita mumamota masero.Chirevo chayo chekurapa ndechekuti: tanga kubaya boron isina chepfu uye isingakuvadzi ine mushonga mumurwere.Mushure mekunge mushonga wapinda mumuviri wemunhu, unokurumidza kunanga uye kuunganidza mune chaiwo cancer maseru.Panguva ino, neutron ray ine zvishoma kukuvadza kumuviri wemunhu inoshandiswa pakuvhenekesa.Mushure mekunge neutron yadhumhana neboron ichipinda mumasero egomarara, "nuclear reaction" yakasimba inogadzirwa, ichiburitsa iro rinouraya rinorema ion ray.Huwandu hwemwaranzi hupfupi kwazvo, hunogona kungouraya maseru egomarara pasina kukuvadza matishu akatenderedza.Iyi yakasarudzika yakanangwa radiotherapy tekinoroji inongouraya maseru egomarara pasina kukuvadza akajairwa matishu inonzi boron neutron capture therapy.
Parizvino, mushonga weBPA boron une GAOJIN biological code ye "gjb01" wapedza tsvakiridzo yemishonga yeAPI nekugadzirira, uye wapedza kuongorora gadziriro yepilot scale.Gare gare, inogona kushandiswa muR & D masangano eBNCT neutron therapy zvishandiso muChina kuita tsvakiridzo yakakodzera, kuyedza uye kiriniki application.Zvakakosha kucherechedza kuti kugadzirwa kwemutyairi ndiyo chinongedzo chinodiwa cheshanduko yebudiriro yesainzi uye tekinoroji kuita masimba anogadzira, uye kubudirira kana kutadza kwemaindasitiri ezviwanikwa zvinonyanya kuenderana nekubudirira kana kutadza kwemutyairi wekugadzira.
Muna Kurume 2020, steboronine, yekutanga pasi rose BNCT mudziyo uye yekutanga pasi rose mushonga weboron, yakatenderwa kushambadzira muJapan kune isingarambike munharaunda kana kenza yemusoro nemutsipa.Pamusoro pezvo, mazana emiedzo yekiriniki yakaitwa mumamota ehuropi, melanoma yakaipa, kenza yemapapu, pleural mesothelioma, kenza yechiropa, uye kenza yemazamu, uye data rakanaka rekurapa rawanikwa.
Cai Shaohui, mutevedzeri wamaneja mukuru uye mutungamiri weprojekiti yeGAOJIN biology, akataura kuti index yese ye "gjb01" inopindirana zvachose nemishonga yesteboronine yakanyorwa muJapan, uye mutengo wekuita wakakwira.Inotarisirwa kushandiswa mukiriniki muna 2023 uye inotarisirwa kuve yekutanga kunyorwa BNCT anti-cancer boron drug muChina.
Cai Shaohui akati, "maitiro epamberi ekurapa kweBNCT haana kupokana.Iyo yakakosha mushonga weboron.Chinangwa chepamusoro cheJin biology ndechekuita kuti kurapwa kweBNCT kweChina kusvike padanho rinotungamira pasirese.Mutengo wekurapa unogona kudzorwa nemazvo kunosvika zviuru zana zveyuan, kuitira kuti varwere vane gomarara varapwe uye vawane mari yekurapa.
"Kurapa kweBNCT kunogona kunzi 'parera pakorona' yekurapa kenza nekuda kwekudhura kwayo, kosi pfupi yekurapa (30-60 maminetsi nguva imwe neimwe, kurapa kwekukurumidza kunogona kurapwa kamwe chete kana kaviri), zviratidzo zvakakura uye zvakaderera. side effects.”Wang Jian, CEO weGAOJIN biology, akati kiyi yakakosha ndeye kunanga nekugadzirira maitiro emishonga yeboron, Inotaridza kana kurapa kuchigona kurapa mamwe marudzi egomarara.
Nguva yekutumira: Nov-25-2021