Vacheche nevana 9 mwedzi kusvika kumakore e4 vane kudya kwesimbi-inoshaya anemia yakave nekuwedzera kukuru kwehemoglobin concentration ne ferrous sulfate kupfuura ne iron-polysaccharide complexes pamasvondo e12, maererano nekuongorora kwekliniki yakabudiswa muJAMA.Big.
Iron-deficiency anemia muvacheche nevana vadiki - inowanzokonzerwa nekunyanya kunwa mukaka wemombe kana kuyamwisa kwenguva refu pasina iron supplementation - yakabata vanhu vanopfuura bhiriyoni pasi rose muna 2010, 3% yavo vaive vane makore 1 kusvika maviri ekuzvarwa muAmerica. .Inowanzoitika muvana vanokura nokukurumidza uye inogona kukonzera kutsamwa, malaise, pica, uye pfupi-uye kwenguva refu neurodevelopmental disorders.
Ferrous sulfate, munyu wesimbi, ndiyo nzira yekurapa kwekudya kwesimbi-inoshaya anemia.Zvisinei, iron-polysaccharide complex ine ferric iron (NovaFerrum, Gensavis Pharmaceuticals) inogona kushandiswa seimwe nzira nokuti inogona kuvandudza kushivirira uye kuravira.
"Kukundikana kwekurapa kunowanzoitika nekuda kwekusateerera kwemishonga, migumisiro yakaipa inobatanidza nekuwedzeredza, uye kushayikwa kweuchapupu-based management guidelines," akadaro Jacquelyn M. Powers, MD, MS, School of Medicine, Baylor Assistant Purofesa wePediatrics uye Hematology. /Oncology, uye vaanoshanda navo vakanyora."Mashoma mashoma ekiriniki miedzo inozivisa kuumbwa kwesimbi kusarudzwa, dosing regimen, uye nguva yekurapa, zvisinei neiyo etiology, zera, kana kuti bonde revanhu vakabatwa."
Masimba uye vashandi vakaongorora iron-polysaccharide complexes mu80 vacheche nevana 9 kusvika 48 mwedzi (yepakati zera, 22 mwedzi; 55% varume; 61% white Hispanic) ine chikafu chinovaka muviri chekushaya anemia Inoshanda kupfuuraferrous sulfatekuwedzera hemoglobin concentration.
Pakati paSeptember 2013 naNovember 2015, vatsvakurudzi vakangoerekana vapa vana kuti vagamuchire 3 mg / kg ye elemental iron kamwe chete pazuva se ferrous sulfate madonhwe (n = 40) kana iron-polysaccharide yakaoma madonhwe (n = 40) = 40) kwemavhiki gumi nemaviri. .
Vabereki kana vatarisiri vakarayirwa kuti vape muyero wezuva nezuva panguva yekurara, kuti varege kusanganisa dosi nechikafu chipi nechipi kana chinwiwa, uye kudzivisa mukaka kweawa 1 mushure mekushandiswa kwemishonga yekudzidza. huwandu hwe600ml pazuva.
Shanduko yehemoglobin pamasvondo e12 yakashanda sechinhu chekutanga chekupedzisira.Secondary endpoints yaisanganisira kugadziriswa kwakakwana kwesimbi inoshaya anemia, kuchinja kweserum ferritin mazinga uye simba rose re-iron-binding, nemigumisiro yakaipa.
Vatori vechikamu makumi mashanu nevapfumbamwe vakapedza kutongwa, makumi maviri nemasere kubva kuboka referrous sulfate uye 31 kubva kuboka re iron-polysaccharide yakaoma.
Kubva pakutanga kusvika pavhiki 12, zvinoreva kuti hemoglobin yakawedzera kubva pa7.9 g/dL kusvika 11.9 g/dL muferrous sulfate group uye kubva 7.7 g/dL kusvika 11.1 g/dL mu iron-polysaccharide complex group, musiyano mukuru we1 g/ dL (95% CI, 0.4-1.6; P <.001) ine ferrous sulfate.
Zvichienzaniswa neboka re iron polysaccharide, vacheche nevana vari muboka re ferrous sulfate vaiva nemazinga akakwirira ekuregererwa kwakakwana kwesimbi inoshaya anemia (29% vs 6%; P = .04) . 15.6 ng / mL muboka re ferrous sulfate uye kubva 2 ng / mL kusvika 7.5 ng / mL mu iron-polysaccharide yakaoma boka, ine musiyano mukuru we 10.2 ng / mL (95 ng / mL).% CI, 6.2-14.1;P <.001) ine ferrous sulfate.
Iyo yepakati yesimbi-yekusunga simba yakadzikira kubva pa501 µg/dL kusvika 389 µg/dL, nepo ferrous sulfate yakaderera kubva pa506 µg/dL kusvika 417 µg/dL, uye iron-polysaccharide yakaoma yaive -50 µg/dC (95% dC). , -86 kusvika -14; P <.001) uye ferrous sulfate.
Diarrhea yaiwanzoonekwa ne iron-polysaccharide complexes pane ferrous sulfate (58% vs 35%; P = .04).
Vatsvakurudzi vakacherechedza kuti 50 muzana yevabereki nevachengeti vakarondedzera kuoma kwekugadzirisa iron-polysaccharide complex, zvichienzaniswa ne65 muzana yeferrous sulfate boka.
Kuganhurirwa kwechidzidzo kwaisanganisira kuti yakaitwa pachipatara chevana vechikoro chepamusoro uye yakanga ine chikamu chisingaenzaniswi chevarwere vane mari shoma uye vashoma vane anemia yakakomba, vanenge 23% vavo vaida kuwedzerwa ropa vasati vanyoresa.
"Izvi zvabuda zvinofanirwa kubatsira kusimudzira mimwe miedzo yekiriniki kuti iongorore kuderera kana kushoma kwedosi remuromo iron," Powers nevamwe vaanoshanda navo vakanyora." Zvinotarisirwa mhedzisiro zvinogona kusanganisira kunatsiridzwa kwekuteerera kwemurwere uye kuwedzera kunyudzwa kwesimbi, zvichikonzera mhinduro yakanaka yehematologic."– Chuck Gormley
Kuburitswa pachena: Gensavis Pharmaceuticals ndivo vakapa chidzidzo ichi mari.
Nguva yekutumira: Mar-21-2022