Madomasi anobereka zvawovitamini Dprecursors.Kuvhara nzira yekuishandura kuita mamwe makemikari kunogona kutungamirira kune precursor accumulation.
Gene-yakagadziridzwa madomasi zvidyarwa zvinogadzira vhitamini D precursors rimwe zuva zvinogona kupa mhuka-isina sosi yekudya kwakakosha.
Inofungidzirwa kuti 1 bhiriyoni vanhu havawani vhitamini D yakakwana - mamiriro ezvinhu anogona kutungamirira kumatambudziko akasiyana-siyana ehutano, kusanganisira zvirwere zvekudzivirira uye zvetsinga.vitamini Dkubva muzvigadzirwa zvemhuka zvakaita semazai, nyama, nemukaka.
Apo madomasi akagadzirwa nemagene anotsanangurwa muNature Plants musi wa23 Chivabvu akaoneswa ultraviolet chiedza murabhoritari, mamwe maprecursors anonzi vitamin D3 akashandurwa kuita vitamin D3. kuti vachazvibata sei kana vakura kunze.
Zvakadaro, anodaro nyanzvi yezvipenyu zvezvirimwa, Johnathan Napier weRothamsted Research muHarpenden, UK, uyu muenzaniso unokurudzira uye usingajairiki wekushandisa gene editing kuvandudza kunaka kwezvirimwa.Zvinoda kunzwisisa kwakadzama nezve biochemistry yemadomasi. zvaunonzwisisa," akadaro.
Gene editing inzira inobvumira vatsvakurudzi kuita shanduko dzakanangidzirwa kugenome yechinhu uye yakarumbidzwa senzira inogoneka yekugadzira zvirimwa zviri nani.Kunyange zvazvo zvirimwa zvakagadziridzwa zvinogadzirwa nekuisa majini mugenome yechirimwa kazhinji zvinofanirwa kuongororwa zvakanyanya nevatongi vehurumende, nyika zhinji dzakagadzirisa maitirwo ezvirimwa zvekugadzirisa genome-chero kugadziridza kuri nyore uye mhedzisiro inokonzeresa inogona kunge iine machinjiro anongoitika .
Asi Napier akati kune nzira shoma dzekushandisa rudzi urwu rwekugadzirisa majini kuvandudza kudya kwezvirimwa.Kunyange zvazvo kugadzirisa kwemajini kuchigona kushandiswa kuvhara majini nenzira dzinobatsira mutengi — semuenzaniso, nekubvisa mishonga yezvirimwa inogona. kukonzera kusawirirana nemuviri—zvakanyanya kuoma kuwana shanduko yejini inoguma nejena.new kudya.” Kuti uwedzere kudya kunovaka muviri, unofanira kudzokera shure wofunga kuti, chishandiso ichi chingabatsire sei?”Napier akadaro.
Kunyange zvazvo zvimwe zvinomera zvichigadzira chimiro chevhitamini D, inowanzoshandurwa gare gare kuva kemikari inodzora kukura kwechirimwa. Kuvhara nzira yekushandura kunotungamirira kukuunganidza kwevhitamini D precursors, asiwo kune kuderera kwechirimwa kukura. kana uchida kugadzira zvirimwa zvinobereka zvakawanda,” anodaro Cathie Martin, nyanzvi yezvezvinomera paJohn Innes Center muNorwich, UK.
Asi manightshades anewo anoenderana biochemical nzira inoshandura provitamin D3 kuita inodzivirira makomisheni.Martin nevamwe vake vakatora mukana uyu kune mainjiniya zvirimwa zvinogadzira vhitamini D3: Vakaona kuti kuvhara nzira kwakatungamira mukuunganidzwa kwevitamini Dprecursors pasina kukanganisa kukura kwechirimwa mulabhu.
Dominique Van Der Straeten, anoongorora zvipenyu zvezvirimwa paGhent University kuBelgium, akati vaongorori vanofanirwa kuona kana kuvharidzira kugadzirwa kwemakomisheni ekudzivirira kana akakura kunze kwerabhoritari kunokanganisa kugona kwemadomasi kurarama nekushushikana kwezvakatipoteredza.
Martin nevamwe vake vanoronga kudzidza izvi uye vakatowana mvumo yekurima madomasi avo akaiswa jena mumunda.Chikwata ichi chaidawo kuyera mhedzisiro yekunze kweUV kuratidzwa pakushandurwa kwevhitamini D3 kuita vhitamini D3 mumashizha emichero nemichero. ”MuUK, zvave kutoparara,” akadaro Martin achiseka, achitaura nezvemamiriro ekunze ekunaya kwemvura. Akataura kuti paakataura nemumwe aishanda kuItaly achimubvunza kana aigona kuita ongororo zuva rakazara, akapindura kuti zvaizoda. anenge makore maviri kuti awane regulatory clearance.
Kana matomatisi akaita zvakanaka muzvidzidzo zvemumunda, anogona kupedzisira abatana nechero mbesa dzinowanikwa kune vatengi.Asi Napier anoyambira kuti mugwagwa unoenda kumusika wakareba uye uzere nezvimhingamipinyi zvinosanganisirwa nenjere dzenjere, mitemo inodiwa uye matambudziko ekugadzirisa zvinhu. Mupunga - rudzi rwechirimwa rwakagadzirwa nevhitamini A - rwakatora makumi emakore kubva pamabhenji erebhu kuenda kumapurazi, usati wapihwa mvumo yekurima kuPhilippines gore rapfuura.
Van Der Straeten’s lab iri kukura zvirimwa zvakagadziridzwa izvo zvinoburitsa mwero wepamusoro wezvakasiyana siyana zvinovaka muviri, zvinosanganisira folate, vhitamini A uye vhitamini B2. Asi anokasira kutaura kuti chirimwa ichi chakasimba chinogona kugadzirisa kushomeka kwekudya. nzira dzatingabatsira nadzo vanhu," akadaro. "Zviripachena zvichatora matanho akasiyana."
Nguva yekutumira: May-25-2022