Chidzidzo mumakonzo chinoratidza kuti kutoravitamini Cinogona kubatsira kurwisa kutambisa tsandanyama, zvakajairika mhedzisiro yechemotherapy drug doxorubicin.Kunyange zvazvo zvidzidzo zvekiriniki zvichidiwa kuona kuchengetedzwa uye kushanda zvakanaka kwekutora vhitamini C panguva yekurapa doxorubicin, zvakawanikwa zvinoratidza kuti vhitamini C inogona kumiririra mukana unovimbisa wekudzikisa mamwe emushonga anonyanya kukanganisa mhedzisiro.
Zvatinowana zvinoratidza kuti vhitamini C ingangoita chirairo chekubatsira kurapa chirwere chetsandanyama chinotevera kurapwa kwe doxorubicin, nekudaro kuvandudza kugona kwehupenyu nehupenyu uye kuderedza kufa.
Antonio Viana do Nascimento Filho, M.Sc., Universidad Nova de Julio (UNINOVE), Brazil, munyori wekutanga wechidzidzo ichi, achapa zvakawanikwa pamusangano wepagore weAmerican Physiological Society panguva yemusangano we2022 Experimental Biology (EB) muPhiladelphia, Kubvumbi 2-5.
Doxorubicin is anthracycline chemotherapy drug iyo inowanzoshandiswa pamwe nemamwe chemotherapy mishonga kurapa gomarara rezamu, dundira, lymphoma, leukemia, uye mamwe akati wandei mamwe marudzi egomarara.Kunyange zvazvo chiri mushonga unorwisa gomarara, doxorubicin inogona kukonzera matambudziko akakomba emwoyo uye kupera kwemhasuru, zvine mhedzisiro yekusimba kwemuviri wevasara uye hupenyu hwehupenyu.
Izvi zvinokonzerwa nemigumisiro inofungidzirwa kuti inokonzerwa nekugadzirwa kwakanyanya kweokisijeni-reactive zvinhu kana "mahara radicals" mumuviri.Vitamin Cndeye yakasikwa antioxidant iyo inogona kubatsira kuderedza oxidative kusagadzikana, rudzi rwekukuvara kunokonzerwa nemahara radicals.
Muchidzidzo chakapfuura neYunivhesiti yeManitoba muCanada, timu yakaona kuti vhitamini C yakavandudza mavanga ehutano hwemoyo uye kurarama mumakonzo akapihwa doxorubicin, kunyanya nekudzikisa oxidative kusagadzikana uye kuzvimba.Muchidzidzo chitsva ichi, vakaongorora kana vhitamini C ingabatsirawo kudzivirira yakashata mhedzisiro yedoxorubicin pane skeletal tsandanyama.
Vatsvakurudzi vakafananidza skeletal muscle mass uye zviratidzo zve oxidative stress mumapoka mana emakonzo, rimwe nerimwe re8 kusvika kumhuka dze10.Boka rimwe rakatora ose ari mavirivitamini Cuye doxorubicin, boka rechipiri rakangotora vhitamini C, boka rechitatu rakangotora doxorubicin, uye boka rechina harina kutora chero.Mbeva dzakapihwa vhitamini C uye doxorubicin dzakaratidza humbowo hwekudzikira oxidative kusagadzikana uye nani tsandanyama misa zvichienzaniswa nembeva dzakapihwa doxorubicin asi kwete vhitamini C.
"Zvinofadza kuti prophylactic uye concomitant kurapwa nevhitamini C yakapihwa svondo rimwe chete doxorubicin isati yasvika uye mavhiki maviri mushure medoxorubicin inokwana kudzikisa mhedzisiro yemushonga uyu paskeletal tsandanyama, nekudaro ichidzikisa Huge yakanaka mhedzisiro paskeletal tsandanyama.Kudzidza nezveutano hwemhuka,” anodaro Nascimento Filho.” Basa redu rinoratidza kuti kurapwa kwevhitamini C kunoderedza kurasikirwa kwetsandanyama uye kunonatsiridza zviratidzo zvakawanda zvemahara radical kusaenzana kwemakonzo akagamuchira doxorubicin.”
Masayendisiti akacherekedza kuti kumwe kutsvagisa, kusanganisira zviyedzo zvekiriniki, zvinodikanwa kusimbisa kana kutora vhitamini C panguva yekurapa doxorubicin kunobatsira muvarwere vevanhu uye kuona dhigirii yakakodzera uye nguva.Ongororo yapfuura inoratidza kuti vhitamini C inogona kukanganisa mhedzisiro yechemotherapy mishonga, saka varwere havakurudzirwe kutora vitamin C yekuwedzera panguva yekurapa cancer kunze kwekunge varairwa nachiremba wavo.
Nguva yekutumira: Kubvumbi-26-2022