Waad ku mahadsan tahay booqashada Nature.com.Nooca browser-ka aad isticmaalayso waxa uu leeyahay taageero xaddidan CSS. Waayo-aragnimada ugu fiican, waxaan kugula talineynaa inaad isticmaasho browserka la cusboonaysiiyay (ama dami qaabka ku habboonaanta ee Internet Explorer) inta ka horeysa, si loo xaqiijiyo Taageerada sii socota, waxaan soo bandhigi doonaa goobta aan lahayn qaabab iyo JavaScript.
In ka badan hal sano, Adeola Fowotade waxa ay isku dayaysay in ay dadka u qorto tijaabooyinka caafimaad ee COVID-19 Hadafkeedu waa in la helo 50 mutadawiciin ah - dadka laga helay COVID-19 kuwaas oo leh calaamado dhexdhexaad ah iyo kuwo daran oo laga yaabo inay ka faa'iidaystaan daroogada cocktail. Laakiin shaqaaleysiinta ayaa socotay xitaa iyadoo Nigeria ay aragtay kiisaska fayraska bilihii January iyo February. Siddeed bilood ka dib, waxay shaqaalaysay 44 qof oo keliya.
"Bukaannada qaarkood waxay diideen inay ka qaybqaataan daraasadda marka la soo dhawaado, qaarna waxay isku raaceen inay joojiyaan kala bar tijaabada," ayuu yiri Fowotade. Marka heerka kiisku bilaabay inuu hoos u dhaco bishii March, waxay ahayd mid aan macquul ahayn in la helo ka qaybgalayaasha. Taasi waxay samaysay tijaabada, oo la yaqaan NACOVID ahaan, way adagtahay in la dhamaystiro.” Ma buuxin kari waynay cabirka muunada ee qorshaysnaa,” ayay tidhi. Tijaabadu waxay dhamaatay Sebtembar oo ay ka gaabisay yoolkii shaqaalaysiinta.
Dhibaatooyinka Fowotade waxay muraayad u yihiin dhibaatooyinka ay la kulmaan tijaabooyinka kale ee Afrika - dhibaatada ugu weyn ee waddamada qaaradda ee aan helin tallaalka COVID-19 ee ku filan Nigeria. Nigeria, oo ah waddanka ugu dadka badan qaaradda, kaliya 2.7 boqolkiiba dadku waa ugu yaraan Qayb ahaan waa la tallaalay.Tani wax yar ayay ka hooseysaa celceliska wadamada dhaqaalahoodu hooseeyo.Qiyaasaha ayaa soo jeedinaya in wadamada Afrika aysan heli doonin qiyaaso ku filan si ay si buuxda u tallaalaan 70% dadka qaaradda ilaa ugu yaraan Sebtember 2022.
Taasi waxay ka dhigeysaa fursado yar oo lagula dagaallamo masiibada hadda. In kasta oo daawaynta sida monoclonal antibodies ama daawada fayraska remdesivir lagu isticmaalo wadamo hodan ah oo ka baxsan Afrika, dawooyinkan ayaa u baahan in lagu maamulo isbitaallada waana qaali. Shirkadda weyn ee dawooyinka Merck ayaa ogolaatay shati ay siiso dawada molnupiravir ee kaniiniga ku saleysan warshado si weyn loogu isticmaali karo, laakiin su'aalaha ayaa weli ah inta ay ku kici doonto haddii la ansixiyo Culayska cudurrada ee hababka daryeelka caafimaadka, iyo dhimista dhimashada.
Ku dhawaad 2,000 oo tijaabo ah oo hadda sahaminta daawaynta dawada ee COVID-19, kaliya 150 ka mid ah ayaa ka diiwaan gashan Afrika, inta badan Masar iyo Koonfur Afrika, sida laga soo xigtay clinicaltrials.gov, xog ururin ay maamusho United Tijaabooyin la'aantu waa dhibaato, ayuu yidhi Adeniyi Olagunju, oo ku takhasusay dawooyinka dawooyinka ee Jaamacadda Liverpool ee UK iyo cilmi-baadhaha hoggaanka NACOVID. Aad u xaddidan, ayuu yidhi. "Ku dar taas helitaanka aadka u hooseeya ee tallaallada," Oragonju ayaa yidhi."In ka badan qaarad kasta oo kale, Afrika waxay u baahan tahay daaweyn waxtar leh oo COVID-19 ah oo ah ikhtiyaari."
Ururada qaar ayaa isku dayaya in ay ka soo kabtaan waxyaabaha dhiman Daraasad kale oo loo yaqaan Dib-u-celinta Ka-hortagga Caabuqa ee COVID-19 Therapy (ReACT) - oo ay isku duba-rideen aasaaska aan faa'iido doonka ahayn Daawooyinka Duumada Venture - waxay tijaabin doontaa badbaadada iyo waxtarka dib-u-soo-celinta daawooyinka ee Koonfur Afrika. Laakiin caqabadaha sharciyeynta, la'aanta Kaabayaasha dhaqaalaha, iyo dhibaatooyinka xagga qoritaanka ka qaybgalayaasha tijaabada ah ayaa caqabado waaweyn ku ah dadaalladan.
"Dalka Saxaraha ka hooseeya, nidaamkayaga daryeelka caafimaadku wuu burburay," ayuu yiri Samba Sow, oo ah cilmi-baare heer qaran ah oo ka tirsan ANTICOV ee Mali.Taasi waxay ka dhigaysaa tijaabooyin adag, laakiin aad loo baahan yahay, gaar ahaan aqoonsiga daawooyinka kuwaas oo caawin kara dadka marxaladaha hore ee cudurka. isaga iyo qaar kale oo badan oo cudurka baranaya, waa tartan dhimasho ah.” Ma sugi karno ilaa bukaanku si daran u bukoon karo,” ayuu yidhi.
Duduzile Ndwandwe oo ah khabiir ku takhasusay cilmiga tallaalka, Duduzile Ndwandwe, ayaa daba-gal ku sameeyay cilmi-baadhis ku saabsan daawaynta tijaabada ah ee Cochrane South Africa, oo qayb ka ah urur caalami ah oo dib u eegis ku sameeya caddaynta caafimaadka, waxaanu yidhi Pan-African Clinical Trials Registry waxa ay diwaangelisay 606 tijaabo caafimaad sanadka 2020 , marka la barbar dhigo 2019 408 (fiiri 'tijaabooyinka kiliinikada ee Afrika').Bishii Ogosto ee sanadkan, waxa ay diiwaangelisay 271 tijaabo, oo ay ku jiraan tijaabooyin tallaal iyo dawooyin.Ndwandwe wuxuu yiri: "Waxaan aragnay tijaabooyin badan oo ballaarinaya baaxadda COVID-19."
Si kastaba ha ahaatee, tijaabooyinka daawaynta coronavirus ayaa wali maqan Caqabada ah in daryeelka caafimaadka la gaarsiiyo bukaanada aadka u xanuunsan ayaa ka ilaalisay wadamada intooda badan inay ku biiraan, ayay tiri Quarraisha Abdool Karim, oo ah khabiir ku takhasusay cudurrada faafa ee Jaamacadda Columbia ee magaalada New York, xarunteeduna tahay Durban, Koonfur Afrika. Waxay tidhi, laakiin waxay dejinaysaa marxaladda tijaabooyin badan oo daawaynta COVID-19. Bishii Ogosto, Ururka Caafimaadka Adduunka wuxuu ku dhawaaqay wajiga xiga ee tijaabada midnimada, kaas oo tijaabin doona saddex daawo oo kale. Shan waddan oo Afrikaan ah ayaa ka qaybqaatay.
Tijaabada NACOVID ee Fowotade waxay ujeedadeedu tahay in lagu tijaabiyo daaweynta isku dhafka ah ee 98 qof oo ku nool Ibadan iyo saddex goobood oo kale oo Nigeria ah.Dadka daraasadda lagu sameeyay waxaa la siiyay dawooyinka ka hortagga retroviral atazanavir iyo ritonavir, iyo sidoo kale daawada antiparasitic ee loo yaqaan nitazoxanide.In kasta oo bartilmaameedka qoritaanka uu ahaa lama kulmin, Olagunju wuxuu sheegay in kooxdu ay diyaarinayso qoraal-gacmeed si loo daabaco waxaana rajeynaya in xogta ay bixin doonto fikrado ku saabsan waxtarka daawada.
Tijaabada ReACT ee Koonfur Afrika, oo ay kafaalo-qaadday Seoul oo ay leedahay shirkadda dawooyinka ee Kuuriyada Koonfureed Shin Poong Pharmaceutical, waxay rabta in ay tijaabiso afar isku darka dawooyinka dib loo soo celiyay: daawaynta ka hortagga duumada artesunate-amodiaquine iyo pyrrolidine-artesunate;Favipiravir, daawada fayruska ka-hortagga hargabka ee loo isticmaalo isku-darka nitre;iyo sofosbuvir iyo daclatasvir, oo ah isku darka fayraska ka hortaga ee inta badan loo isticmaalo daawaynta cagaarshowga C.
Isticmaalka dawooyinka dib loo soo celiyay ayaa aad u soo jiidanaya cilmi-baarayaal badan sababtoo ah waxay noqon kartaa dariiqa ugu macquulsan ee si degdeg ah loogu heli karo daawaynta si fudud loo qaybin karo.La'aanta Afrika ee kaabayaasha cilmi-baarista, horumarinta iyo wax-soo-saarka daroogada waxay la macno tahay dalalku si fudud uma tijaabin karaan xeryahooda cusub iyo dawooyin badan oo soo saara. Dadaalkaasi waa halis, ayay tiri Nadia Sam-Agudu, oo ku takhasustay cudurrada faafa ee carruurta kana tirsan Jaamacadda Maryland oo ka shaqeysa Machadka Nigeria Institute of Human Virology ee Abuja. suurto gal [joojin] gudbinta sii socota," ayay raacisay.
Tijaabada ugu weyn qaaradda, ANTICOV, ayaa la bilaabay Sebtembar 2020 iyadoo la rajaynayo in daawaynta hore ay ka hortagi karto COVID-19 in uu dhaafo nidaamyada daryeelka caafimaadka jilicsan ee Afrika. Waxa ay hadda shaqaaleysiinaysaa in ka badan 500 oo kaqeybgale ah 14 goobood oo ku yaal Jamhuuriyadda Dimuqraadiga ah ee Congo, Burkina Faso. Faso, Guinea, Mali, Ghana, Kenya iyo Mozambique.Waxay hiigsaneysaa in ay ugu dambeyntii qorto 3,000 oo kaqeybgale ah 13 wadan.
Shaqaale jooga qabuuraha ku yaal Dakar, Senegal, bishii Ogosto sida mowjad saddexaad oo ah infekshannada COVID-19 ayaa ku dhacay. Lahaanshaha sawirka: John Wessels/AFP/Getty
ANTICOV waxay tijaabinaysaa waxtarka laba daawaynta isku dhafan oo natiijooyin isku dhafan meelo kale ka helay. Midka kowaad wuxuu isku daraa nitazoxanide iyo ciclesonide la neefsado, corticosteroid oo loo isticmaalo daaweynta neefta. Midka labaad wuxuu isku daraa artesunate-amodiaquine iyo daawada antiparasitic ivermectin.
Isticmaalka ivermectin ee daawaynta xoolaha iyo daawaynta qaar ka mid ah cudurrada kulaylaha ee la dayacay ee bini'aadamka ayaa dhaliyay muran wadamo badan. Shakhsiyaadka iyo siyaasiyiinta ayaa dalbanayay isticmaalkeeda si loogu daweeyo COVID-19 sababtoo ah caddayn aan ku filnayn iyo caddayn cilmi ah oo ku saabsan waxtarkeeda. Xogta taageereysa isticmaalkeeda ayaa ah mid la is weydiinayo.Masar, daraasad ballaaran oo lagu taageerayo isticmaalka ivermectin ee bukaannada COVID-19 ayaa laga saaray server-ka preprint ka dib markii la daabacay iyada oo ay jirto eedeymo la xiriira xog-darro iyo been abuur. daabacayaashu ma aysan siin fursad ay isku difaacaan Nidaamka Rev. 7, CD015017; 2021).
Nathalie Strub-Wourgaft, oo maamusha ololaha DNDi ee COVID-19, ayaa sheegtay inay jirto sabab sharci ah oo lagu tijaabiyo dawada Afrika dhexdeeda. Iyada iyo asxaabteeda waxay rajeynayaan inay u dhaqmi karto sida ka hortagga bararka marka lagu qaato daawada ka hortagga duumada. la ogaaday inay maqan tahay, DNDi waxay diyaar u tahay inay tijaabiso daawooyinka kale.
"Arrinta ivermectin waa la siyaasadeeyay," ayuu yiri Salim Abdool Karim, oo ah khabiir ku takhasusay cudurrada faafa isla markaana ah maamulaha Xarunta Cilmi-baarista AIDS-ka ee fadhigeedu yahay Durban ee Koonfur Afrika (CAPRISA)." Laakiin haddii tijaabooyinka Afrika ay gacan ka geysan karaan xallinta dhibaatadan ama wax ku biirin muhiim ah , markaa waa fikrad wanaagsan."
Iyada oo ku saleysan xogta la hayo ilaa maanta, isku darka nitazoxanide iyo ciclesonide waxay u muuqataa rajo, Strub-Wourgaft ayaa yiri. -Wourgaft wuxuu sheegay in ANTICOV ay isku diyaarinayso inay tijaabiso cudud cusub ayna sii wadi doonto isticmaalka laba gacmood oo daawaynta ah.
Bilawga tijaabada waxay ahayd caqabad, xitaa DNDi oo leh khibrad shaqo oo ballaaran oo ku saabsan qaarada Afrika. Oggolaanshaha sharciyeynta waa cilad weyn, ayuu yiri Strub-Wourgaft. Sidaa darteed, ANTICOV, oo kaashanaysa WHO's African Vaccine Regulatory Forum (AVAREF), ayaa sameeyay xaalad degdeg ah. habraaca lagu sameeyo dib u eegis wadajir ah oo ku saabsan daraasadaha kiliinikada ee dalalka 13. Tani waxay soo dedejin kartaa ansixinta sharciyeynta iyo anshaxeedka. "Waxay noo ogolaataa inaan isu keeno dawladaha, sharciyeeyayaasha iyo xubnaha guddiga dib u eegista anshaxa," ayuu yiri Strub-Wourgaft.
Nick White, oo ah khabiir ku takhasusay dawada kulaylaha oo madax ka ah dalada cilmi baarista kiliinikada ee COVID-19, iskaashiga caalamiga ah si xal loogu helo COVID-19 ee wadamada dakhligoodu hooseeyo, ayaa sheegay in in kasta oo hindisaha WHO uu ahaa mid wanaagsan, laakiin wali waxay qaadanaysaa waqti dheer in la helo ogolaanshaha , iyo cilmi baarista wadamada dakhligoodu hooseeyo iyo kuwa dhexdhexaadka ah ayaa ka wanaagsan cilmi baarista wadamada qaniga ah.Sababaha waxaa ka mid ah nidaamyada adag ee sharciyeynta ee wadamadan, iyo sidoo kale maamulada aan ku wanaagsaneyn in ay sameeyaan baaritaan anshaxa iyo sharciyeed. Taasi waa inay isbedelaan, Caddaan "Haddii waddamadu rabaan inay xal u helaan COVID-19, waa inay caawiyaan cilmi-baarayaashooda inay sameeyaan cilmi-baaris lagama maarmaanka ah, oo aysan ka hor istaagin."
Laakiin caqabadaha halkaas kuma eka. Marka ay tijaabadu bilaabato, saadka iyo koronta la'aanta ayaa hor istaagi karta horumarka, ayay tidhi Fowotade. Waxay ku kaydisay muunada COVID-19 qaboojiyaha -20 °C inta lagu guda jiro korontadu ee cisbitaalka Ibadan. Waxa kale oo ay u baahan tahay in shaybaarada loo qaado Xarunta Ed, oo laba saacadood u jirta, si loo falanqeeyo.
Olagunju wuxuu intaas ku daray in markii gobollada qaar ay joojiyeen maalgelinta xarumaha go'doominta ee COVID-19 ee isbitaalladooda, qoritaanka kaqeybgaleyaasha tijaabada ayaa noqotay mid aad u adag. mas'uuliyadda maalgelinta go'doominta iyo xarumaha daaweynta.Qofna ma fileyn in la carqaladeeyo,” Olagunju ayaa yiri.
In kasta oo ay guud ahaan si fiican u kheyr badan tahay, haddana Nigeria sida cad kama qayb qaadanayso ANTICOV. "Qof kastaa wuu ka fogaanayaa tijaabooyinka caafimaad ee Nigeria sababtoo ah ma lihin ururka," ayuu yidhi Oyewale Tomori, khabiir ku takhasusay fayrasyada iyo guddoomiyaha La-talinta Wasiirka COVID-19 ee Nigeria Guddiga khubarada, kaas oo ka shaqeeya sidii loo aqoonsan lahaa xeelado wax ku ool ah iyo hababka ugu wanaagsan ee lagula tacaali karo COVID-19.
Babatunde Salako, oo ah maamulaha Machadka Cilmi-baarista Caafimaadka ee Nigeria ee Lagos, ayaa khilaafsan.Salako wuxuu sheegay in Nigeria ay leedahay aqoonta ay ku sameyso tijaabooyin caafimaad, iyo sidoo kale qoritaanka isbitaalka iyo guddiga dib u eegista anshaxa firfircoon ee isku dubaridi doonta oggolaanshaha tijaabooyinka caafimaad ee Nigeria. xagga kaabayaasha, haa, way daciifi kartaa;weli way taageeri kartaa tijaabooyinka caafimaad,” ayuu yidhi.
Ndwandwe waxay doonaysaa inay dhiirigeliso cilmi-baarayaal Afrikaan ah oo dheeraad ah si ay ugu biiraan tijaabooyinka bukaan-socodka si ay muwaadiniinteedu u helaan sinnaan si ay u helaan daaweyn rajo leh. , maareeyaha tijaabooyinka kiliinikada ee Barnaamijka Cilmi-baarista ee Wellcome Trust ee Machadka Cilmi-baarista Caafimaadka Kenya ee Kilifi.
"COVID-19 waa cudur faafa oo cusub, sidaas darteed waxaan u baahanahay tijaabooyin caafimaad si aan u fahanno sida waxqabadyadani ay ugu shaqeyn doonaan dadka Afrikaanka ah," Ndwandwe ayaa ku daray.
Salim Abdul Karim waxa uu rajeynayaa in dhibaatadu ay dhiiri galin doonto saynis yahanada Afrikaanka ah si ay u dhisaan qaar ka mid ah kaabayaasha cilmi baarista ee loo dhisay si loola dagaalamo cudurka HIV/AIDS-ka.”Wadamada qaar sida Kenya, Uganda iyo Koonfur Afrika ayaa leh kaabayaal horumarsan.Laakiin wuu ku yar yahay meelaha kale,” ayuu yidhi.
Si loo xoojiyo tijaabooyinka caafimaad ee daawaynta COVID-19 ee Afrika, Salim Abdool Karim waxa uu soo jeedinayaa abuurista wakaalad sida Dalladda Tijaabada Caafimaad ee Tallaalka COVID-19 (CONCVACT; oo ay abuurtay Xarumaha Afrika ee Xakamaynta iyo Kahortagga Cudurrada bishii Luulyo 2020) Midowga Afrika – oo ah ururka qaaradaha ee ka wakiil ah 55 waddan oo Afrikaan ah – ayaa si wanaagsan loo meel-mariyey mas’uuliyaddan. ayuu yiri Saalim Cabdul Kariim.
Faafida COVID-19 waxa kaliya oo lagaga gudbi karaa iskaashi caalami ah iyo iskaashi cadaalad ah, ayuu yidhi Sow.” Dagaalka caalamiga ah ee ka dhanka ah cudurrada faafa, waddan waligii kali ma noqon karo - xitaa qaarad ma noqon karo,” ayuu yidhi.
11/10/2021 Caddeyn: Nooc hore oo maqaalkan ah ayaa sheegay in barnaamijka ANTICOV ay maamusho DNdi. Dhab ahaantii, DNDi waxay isku dubariday ANTICOV, oo ay maamulaan 26 la-hawlgalayaal.
Waqtiga boostada: Abriil-07-2022