News.pharmnet.com.cn 2021-11-25 Shabakadda Wararka Shiinaha
Noofambar 23, Chongqing GAOJIN Biotechnology Co., Ltd. Daawooyinka boron ee ugu horreeya ee BPA boron ee burooyinka halista ah sida melanoma, kansarka maskaxda iyo glioma, taas oo lagu daaweeyay BNCT, oo ah boron neutron qabashada therapy Ilaa 30 daqiiqo waxay daweyn kartaa noocyo kala duwan oo kansar ah.
BNCT waa mid ka mid ah hababka daaweynta kansarka ugu horumarsan ee adduunka.Waxay burburisaa unugyada kansarka iyada oo loo marayo fal-celinta nukliyeerka ee unugyada burooyinka.Mabda'eeda daawaynta waa: marka hore ku duri boron aan sun ahayn oo aan waxyeello lahayn oo ay ku jirto daawada bukaanka.Ka dib marka daawadu gasho jidhka bini'aadamka, waxay si dhakhso ah u bartilmaameedsanaysaa oo ku ururtay unugyada kansarka ee gaarka ah.Waqtigaan, raajo neutron ah oo waxyeelo yar u geysta jirka bini'aadamka ayaa loo isticmaalaa shucaaca.Ka dib markii neutronku ay isku dhacaan boron soo galaya unugyada kansarka, "falcelin nukliyeer ah" oo xooggan ayaa abuurma, oo sii daaya rayn culus oo aad u khatar ah.Kala duwanaanshaha fallaadhku aad buu u gaaban yahay, kaas oo dili kara oo keliya unugyada kansarka iyada oo aan waxyeello u geysan unugyada ku xeeran.Tiknooloojiyada shucaaca ee bartilmaameedka ah ee la xushay oo kaliya disha unugyada kansarka iyada oo aan waxyeello u geysan unugyada caadiga ah waxaa loo yaqaan daawaynta qabsashada boron neutron.
Waqtigan xaadirka ah, dawada boron ee BPA ee leh GAOJIN code bayooloji ee "gjb01" waxay dhamaystirtay cilmi baarista dawada ee API iyo diyaarinta, waxayna dhamaystirtay xaqiijinta habka diyaarinta cabirka tijaabada.Later, waxaa loo isticmaali karaa xarumaha R & D ee BNCT qalabka daaweynta neutron ee Shiinaha si loo sameeyo cilmi-baaris ku habboon, tijaabo iyo codsi caafimaad.Waxa xusid mudan in wax-soo-saarka tijaabada ahi uu yahay xidhiidh lama huraan u ah isu-beddelka guulaha cilmi-baadhiseed iyo teknoloojiyadda oo loo beddelo cudud wax-soo-saar leh, waxaana guusha iyo guul-darrida warshadaynta guulaha ay inta badan ku xidhan tahay guusha ama guul-darrada soo-saarka duuliyaha.
Bishii Maarso 2020, steboronine, oo ah qalabkii ugu horreeyay ee BNCT ee adduunka iyo dawadii boron-ka ahayd ee ugu horreysay adduunka, ayaa loo oggolaaday suuq-geynta Japan ee kansarka madaxa iyo qoorta ee soo noqnoqda.Intaa waxaa dheer, boqolaal tijaabo caafimaad ah ayaa lagu sameeyay burooyinka maskaxda, melanoma malignant, kansarka sambabada, mesothelioma pleural, kansarka beerka, iyo kansarka naasaha, iyo xog daaweyn wanaagsan ayaa la helay.
Cai Shaohui, ku xigeenka maareeyaha guud iyo hogaamiyaha mashruuca ee bayoloji GAOJIN, ayaa sheegay in tusaha guud ee "gjb01" uu si buuxda ula jaan qaadayo daawooyinka steboronine ee ku qoran Japan, iyo waxqabadka kharashka ayaa ka sarreeya.Waxaa la filayaa in loo isticmaalo bukaan-socod sanadka 2023 waxaana la filayaa inay noqoto dawada boron-ka-hortagga ee BNCT ee ugu horreysa ee Shiinaha.
Cai Shaohui ayaa yiri, "dabeecada sare ee daaweynta BNCT waa mid aan shaki lahayn.Xuddunta waa daawada boron.Hadafka sare ee bayooloojiyada Jin waa in la sameeyo daawaynta Shiinaha ee BNCT inay gaadho heerka ugu horreeya ee adduunka.Qiimaha daawaynta waxaa si wax ku ool ah loo xakameyn karaa ilaa 100 kun oo Yuan, si bukaanada qaba kansarka ay u helaan daaweyn caafimaad oo ay u helaan lacag ay ku daweeyaan."
"Daawaynta BNCT waxaa loogu yeeri karaa 'luul taajka' ee daaweynta kansarka sababtoo ah qiimaha jaban, koorsada gaaban ee daaweynta (30-60 daqiiqo mar kasta, daaweynta ugu dhaqsaha badan waxaa lagu daweyn karaa hal ama laba jeer oo keliya), tilmaamo ballaaran iyo hoose waxyeellooyinkeeda.”Wang Jian, oo ah maamulaha GAOJIN bayooloji, ayaa sheegay in furaha ugu muhiimsan uu yahay bartilmaameedka iyo habka diyaarinta daawooyinka boron, Waxay go'aamisaa in daawadu ay si ka wanaagsan oo sax ah u daaweyn karto noocyo badan oo kansar ah.
Waqtiga boostada: Nov-25-2021