Dhallaanka iyo carruurta da'doodu u dhaxayso 9 bilood ilaa 4 sano jir ee qaba dhiig-yarida birta-yarida nafaqeynta ayaa kor u kac weyn ku yeeshay uruurinta haemoglobin oo leh ferrous sulfate marka loo eego dhismooyinka birta-polysaccharide ee toddobaadyada 12, marka loo eego tijaabo caafimaad oo la kala soocay oo lagu daabacay JAMA.Wayn
Dhiig-yarida birta-yarida dhallaanka iyo carruurta yaryar - inta badan waxaa sababa isticmaalka xad-dhaafka ah ee caanaha lo'da ama naas-nuujinta dheeraadka ah iyada oo aan la helin birta ku habboon - waxay saamaysay in ka badan 1 bilyan oo qof adduunka oo dhan sannadkii 2010, kuwaas oo 3% ka mid ah ay ahaayeen 1 ilaa 2 sano Carruurta Maraykanka Waxay caadi ahaan ku dhacdaa carruurta si degdeg ah u koraysa waxayna sababi kartaa xanaaq, calool-xumo, pica, iyo xanuunada korriinka neerfaha ee muddada-gaaban iyo muddada dheer.
Ferrous sulfate, cusbo bir ah, waa daaweynta caadiga ah ee nafaqo-yarida dhiig-yaraanta birta. Si kastaba ha ahaatee, iskudhafka birta-polysaccharide ee ka kooban birta ferric (NovaFerrum, Gensavis Pharmaceuticals) ayaa loo isticmaali karaa beddelka sababtoo ah waxay hagaajin kartaa dulqaadka iyo dhadhanka.
"Daawaynta fashilantay waa wax caadi ah sababtoo ah daawadu waxay u hoggaansami la'dahay, saameynaha xun ee la xidhiidha xad-dhaafka ah, iyo la'aanta tilmaamaha maaraynta caddaynta ku salaysan," ayuu yiri Jacquelyn M. Powers, MD, MS, Dugsiga Daawada, Kaaliyaha Baylor Barfasoor ee Caafimaadka Carruurta iyo Hematology / Oncology, iyo asxaabtiisuba way qoreen." Tijaabooyin caafimaad oo yar oo la kala soocay ayaa sheegaya xulashada qaabaynta birta, habka qiyaasta, iyo muddada daawaynta, iyada oo aan loo eegin etiology-ga hoose, da'da, ama jinsiga shakhsiyaadka ay saamaysay."
Awoodaha iyo asxaabtu waxay qiimeeyeen dhismayaasha birta-polysaccharide ee 80 dhallaanka ah iyo carruurta 9 ilaa 48 bilood (da'da dhexe, 22 bilood; 55% lab; 61% Hisbaanik cad) oo leh dhiig-yarida birta nafaqeynta miyuu ka waxtar badan yahayferrous sulfatesi loo kordhiyo xoogga haemoglobin.
Intii u dhaxaysay Sebtembar 2013 iyo Noofambar 2015, cilmi-baarayaashu waxay si aan kala sooc lahayn ugu qoondeeyeen carruurta inay helaan 3 mg/kg oo birta curiyaha ah hal mar maalin kasta sida dhibco sulfate ah oo sulfate ah (n = 40) ama dhibciyada isku dhafan ee iron-polysaccharide (n = 40) = 40) muddo 12 toddobaad ah. .
Waalidiinta ama daryeelayaasha waxaa lagu wargeliyay inay maamulaan qiyaasta maalinlaha ah xilliga hurdada, si ay uga fogaadaan inay ku daraan qiyaasta cunto ama cabitaan kasta, iyo inay ka fogaadaan caanaha 1 saac ka dib maamulka daroogada. ugu badnaan 600ml maalintii.
Isbeddelka hemoglobin ee toddobaadyada 12 ayaa u adeegay sidii barta ugu dambeysa ee asaasiga ah. Dhibcaha labaad waxaa ka mid ah xallinta dhammaystiran ee dhiig-yaraanta birta, isbeddelka heerarka ferritin ee serum iyo guud ahaan awoodda isku-xidhka birta, iyo saameynta xun.
Konton iyo sagaal ka qaybgalayaashu waxay dhammeeyeen tijaabada, 28 ka socda kooxda ferrous sulfate iyo 31 oo ka socda kooxda isku dhafan ee birta-polysaccharide.
Laga soo bilaabo gundhigga ilaa toddobaadka 12, celceliska haemoglobin wuxuu kordhay min 7.9 g/dL ilaa 11.9 g/dL ee kooxda ferrous sulfate iyo min 7.7 g/dL ilaa 11.1 g/dL ee kooxda kakaxan birta-polysaccharide, farqi weyn oo ah 1 g / dL (95% CI, 0.4-1.6; P <.001) oo leh ferrous sulfate.
Marka la barbar dhigo kooxda polysaccharide birta, dhallaanka iyo carruurta ku jira kooxda ferrous sulfate waxay lahaayeen heerar sare oo dhammaystiran oo ah cafiska yaraanta birta (29% vs 6%; P = .04) 15.6 ng/mL ee kooxda ferrous sulfate iyo laga bilaabo 2 ng / mL ilaa 7.5 ng / mL ee kooxda adag ee birta-polysaccharide, oo leh farqi weyn oo ah 10.2 ng / mL (95 ng / mL).% CI, 6.2-14.1;P <.001) oo leh ferrous sulfate.
Wadarta celceliska awoodda isku-xidhka birta ayaa hoos uga dhacday 501 µg/dL ilaa 389 µg/dL, halka ferrous sulfate uu hoos uga dhacay 506 µg/dL ilaa 417 µg/dL, iyo isku dhafka birta-polysaccharide wuxuu ahaa -50 μg/dL (95% CI). , -86 ilaa -14; P <.001) iyo ferrous sulfate.
Shubanku wuxuu aad ugu badan yahay isku-dhafyada birta-polysaccharide marka loo eego ferrous sulfate (58% vs 35%; P = .04).
Cilmi-baadhayaashu waxay xuseen in boqolkiiba 50 waalidiinta iyo daryeel-bixiyeyaasha ay sheegeen in ay ku adag tahay maareynta isku-dhafka birta-polysaccharide, marka la barbardhigo 65 boqolkiiba kooxda ferrous sulfate.
Xaddidaadda daraasadda waxaa ka mid ahaa in lagu sameeyay isbitaal carruurta lagu xanaaneeyo oo aan la qiyaasi karin oo ah bukaannada dakhligoodu hooseeyo iyo kuwa laga tirada badan yahay ee qaba dhiig-yaraan daran, qiyaastii 23% kuwaas oo u baahday dhiig ku shubista ka hor isdiiwaangelinta.
"Natiijooyinkani waa inay caawiyaan soo dedejinta tijaabooyin caafimaad oo dheeraad ah si loo qiimeeyo qiyaasta hoose ama ka yar ee birta afka ah," Awoodaha iyo asxaabtu waxay qoreen."- Chuck Gormley
Shaacinta: Gensavis Pharmaceuticals ayaa maalgelisay daraasaddan. Cilmi-baadhayaashu ma soo sheegaan wax caddayn dhaqaale ah oo khuseeya.
Waqtiga boostada: Mar-21-2022