Chloramphenicol sodium succinateke phofo e tšoeu kapa e mosehla-tšoeu ea hygroscopic.1.4 g ea ntho ea monograph e batla e lekana le 1 g ea chloramphenicol.
Tlhokomelo
Chtoramphenicot e hanyetsanoa ho bakuli ba nang le nalane ea hypersensitivity kapa karabelo e chefo ho sethethefatsi.Ha ea lokela ho fanoa ka mokhoa oa tsamaiso bakeng sa tšoaetso e nyenyane kapa bakeng sa prophylaxis.Tšebeliso e ts'oanang ea chtoramphenicot le lithethefatsi tse ling tse loketseng ho thefula lesapo la moko o lokela ho qojoa.Likoahelo tse fokotsehileng li lokela ho fuoa bakuli ba nang le ts'ebetso ea sebete e sa sebetseng hantle.Chloramphemcol e ka kena-kenana le nts'etsopele ea ho itšireletsa mafung 'me ha ea lokela ho fanoa nakong ea ente e sebetsang.
Litšebelisano
Chloramphenicol e sebetsa ka har'a sebete, ka hona, e ka sebelisana le lithethefatsi tse sebelisoang ke li-enzyme tsa hepatic microsomal.Ka mohlala, chloramphenicol e ntlafatsa liphello tsa li-anticoagulants tsa coumarm tse kang dicoumarol le warfarin sodium, hypoglycemic e itseng e kang chlorpropamide le tolbutamide, le antiepiteptics tse kang phenytoin, 'me e ka fokotsa metabolism ea cuctophosphamufe hore e be sebopeho sa eona se sebetsang.Ka lehlakoreng le leng, metabolism ea chloramphemcol e ka 'na ea eketsoa ke li-enzyme tsa sebete tse kang phenobarbitone kapa nfampicin.Liphetho tse hanyetsanang li tlalehiloe ka paracetamol le phenytoin.Chloramphenicol e ka fokotsa litlamorao tsa tšepe le vithamine Bi2 ho bakuli ba phokolo ea mali le ho sitisa tšebetso ea lithibela-pelehi tse nooang.
Ketso ea Antimicrobial
Chloramphe.nicol ke g bacteriostatic lithibela-mafu tse nang le tšebetso e pharaletseng khahlanong le libaktheria tsa Gram-posi-tive le Gram-negative, hammoho le likokoana-hloko tse ling.
Lisebelisoa le Tsamaiso
V Boikarabello, ba chloranphenicol ho hlahisa liphello tse kotsi tse kotsi bophelong, haholo-holo bone-mar-row aplasia,.e fokolitse haholo molemo oa eona oa bongaka, le hoja e ntse e sebelisoa haholo linaheng tse ling.Le ka mohla ha ea lokela ho ba giyen ka mokhoa o hlophisitsoeng, hobane ts'oaetso e nyane le lipalo tse tloaelehileng tsa mali hangata li eletsoa nakong ea kalafo.Li-cephalosporins tsa moloko oa boraro li se li ratoa bakeng sa matšoao a pele a chlorampheniclo.Ka lebaka leo, ho na le matšoao a fokolang a hlakileng a tšebeliso ea chloramphenicol.E 'nile ea sebelisoa ho typhoid e matla le mafu a mang a salmonella, le hoja e sa felise boemo ba moputso.Chloramphenicol ke mofuta o mong ho feta oa moloko oa boraro oa cephalosporin kalafong ea bacterial meningitis, ka bobeli ka matla le khahlano le likokoana-hloko tse utloang bohloko joalo ka Haemophtlus tnfluenzae.E 'nile ea sebelisoa ho phekola mafu a matla a anaerobic, patricularly abscesses boko, le tšoaetsong e ka tlaase ho diaphragm moo Bacteroides fragitis e atisang ho ameha teng;leha ho le joalo, hangata ho khethoa lithethefatsi tse ling.Le hoja li-tetracycline e ntse e le eona phekolo e khethiloeng ho mafu a rickettsial a kang typhus le s, potted fevers, chforamphenicol e boetse e sebelisoa e le mokhoa o mong moo tetracyclines, e ke keng ea fanoa.
Mafu a mang a baktheria ao chloramphenicol e ka sebelisoang ho ona ho fapana le lithethefatsi tse ling a kenyelletsa koatsi, tšoaetso e matla ea systemic Campylobacter fetus, ehrlichiosis, gastro-ententis e matla, gas gangrene, granuloma inguinale, mafu a matla a Haemophitus influenzae ntle le meningitis (mohlala epiglottitis), listeriosis, metioidosis e matla, lefu la seoa (haholo-holo haeba meningitis e hlaha), psittacosis, tularaemia (haholo-holo[y ha ho belaelloa meningitis), le lefu la Whipple.Bakeng sa, lintlha tsa ts'oaetso ena le kalafo ea tsona..
Chioramphenicol e sebelisoa haholo kalafong ea li-topical, ea litsebe le, ka ho khetheha, mafu a mahlo, ho sa tsotellehe hore tse ngata tsa tsona li bonolo ebile li na le selflimitmg.E boetse e sebelisoa ka holimo ho kalafo ea mafu a skm.Litekanyetso li hlahisoa ka litekanyo tsa chloramphenicol base 'me li tšoana ho sa tsotellehe hore na li tsamaisoa ka molomo kapa ka methapo.Bakeng sa batho ba baholo le bana, tekanyetso e tloaelehileng ke 5O mg ka kilo ea boima ba 'mele letsatsi le leng le le leng ka litekanyetso tse arohaneng lihora tse ling le tse ling tse 6;ho fihlela ho 100 mg ka kg ka letsatsi ho ka fuoa m meningitis kapa tšoaetso e matla ka lebaka la likokoana-hloko tse hanyetsanang ka mokhoa o itekanetseng, le hoja litekanyetso tsena tse phahameng li lokela ho fokotsoa kapele kamoo ho ka khonehang.Ho fokotsa ts'oaetso ea ho khutlela mokhoeng ho khothalelitsoe hore kalafo e fetisetsoe ka mor'a hore mocheso oa mokuli o khutlele ho tloaelehileng bakeng sa matsatsi a mang a 4 a mafu a nckettsial le matsatsi a 8 ho isa ho a 10 ho lever ea typhoid.
Haeba ho se na mokhoa o mong oa tšebeliso ea çhloramphenicol, pele ho nako le ka botlalo, masea a ka fuoa litekanyetso tsa letsatsi le letsatsi tsa 25 mg ka kilo ea boima ba 'mele le masea a nako e telele a fetang libeke tse 2, a ka fuoa ho fihla ho 50 mg. ka k'hilograma ka letsatsi, m 4 litekanyetso li arotsoe: Ho bohlokoa haholo ho qoba ho chefo ho feta tekano ea plasma.
Ho bakuli ba nang le ts'ebetso e sa sebetseng hantle ea renal kapa renal inipainnent, lethal dose ea chloramphenicol e ka 'na ea hloka ho fokotsoa ka lebaka la ho fokotseha kapa ho tsoa ha renal.
Ha ho phekoloa mahlo a mahlo, chloramphenicol hangata e sebelisoa e le tharollo ea 0.5% kapa e le mafura a 1%.
Liphello Tse Mpe
Chloramphemcol e ka baka litlamorao tse mpe ka linako tse ling tse mpe.E 'ngoe ea chefo ea eona ho nahanoa hore e bakoa ke litlamorao tsa protheine ea mitochondnal.Phello e mpe ka ho fetisisa ea senous ea chloramphemcol ke ho tepella maikutlo ha moko oa masapo, o ka nkang mefuta e 2 e fapaneng.Ea pele ke ho tepella maikutlo ho tloaelehileng ho amanang le lethal dose hangata ho etsahalang ha plasma-chloramphenicol concentrations feta 25 ug permL 'me e tšoauoa ka morphological chapges m moko oa lesapo, fokotseha tshebediso ya tšepe, reticulocylopenia khaello ea mali, leukopenia le thrombocytopenia.Phello ena e ka ba ka lebaka la ho thibela protheine synthesis ka mitochomária ea lisele tsa moko oa lesapo.Anaphylaxis e etsahetse empa e sa tloaeleha, maikutlo a kang Jansch-Herxheimer le ona a ka hlaha.Matšoao a ka mpeng a kenyeletsang ho nyekeloa ke pelo, ho hlatsa le letšollo a ka latela tsamaiso ea molomo.Litšitiso tsa limela tsa molomo le tsa mala, li ka baka stomatitis, glossitis, le ho hlohlona ha rectal, Bakuli ba ka ba le tatso e bohloko haholo ka mor'a tsamaiso e potlakileng ea methapo ea chloramphenicot sodium succinate.
Tekanyetso e feteletseng
Charcoal haemoperfusion e ile ea fumanoa e phahametse hole ho fapanyetsana tšelo ea mali ka remval ea chloramphenicol form mali, le hoja e ile ea thibela lefu la ma 7-week-old mfant le lefu la grey baby ka mor'a phoso ea crosage.
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