I-Amoxicillin-clavulanate inokuphucula ukusebenza kwamathumbu amancinci kubantwana abafumana ukuphazamiseka kokuhamba

I-antibiotic eqhelekileyo,amoxicillin-clavulanate, inokuphucula ukusebenza kwamathumbu amancinci kubantwana abafumana ukuphazamiseka kwe-motility, ngokutsho kophando oluvela kwi-Juni print edition ye-Journal ye-Pediatric Gastroenterology kunye neZondlo kwiSibhedlele seSizwe saBantwana.

I-Amoxicillan-clavulanate, ekwabizwa ngokuba yi-Augmentin, idla ngokumiselwa ukunyanga okanye ukuthintela usulelo olubangelwa ziibhaktheriya.Nangona kunjalo, kuye kwaxelwa ukuba yonyusa ukuhamba kwamathumbu amancinci kubantu abasempilweni kwaye isetyenziselwe ukunyanga ukukhula kwebhaktheriya kwizigulana ezinesifo sohudo esingapheliyo.

Iimpawu eziphezulu zesisu ezinjengesicaphucaphu, ukuhlanza, iintlungu zesisu, ukuhlutha kwangoko kunye nokuphazamiseka kwesisu zixhaphakile ebantwaneni.Ngaphandle kwenkqubela phambili yetekhnoloji yokufumanisa ukuphazamiseka kokuhamba, kusaqhubeka ukunqongophala kwamayeza afumanekayo kunyango lwendlela yokusebenza yentsholongwane yesisu.

"Kukho isidingo esibalulekileyo samachiza amatsha okunyanga iimpawu eziphezulu zesisu kubantwana," kusho uCarlo Di Lorenzo, MD, oyintloko ye-Gastroenterology, i-Hepatology kunye neZondlo kwiSibhedlele sabantwana beSizwe kunye nomnye wababhali bokufunda."Amachiza asetyenziswayo ngoku ahlala efumaneka kuphela kwisiseko esithintelweyo, aneziphumo ebezingalindelekanga ezibalulekileyo okanye awasebenzi ngokwaneleyo kumathumbu amancinci namakhulu."

Ukuphonononga ukuba ingaba i-amoxicillin-clavulanate inokusebenza njengokhetho olutsha lokunyanga ukusebenza komgudu wesisu esiswini, abaphandi kuBantwana beSizwe bavavanya izigulana ezingama-20 ebezicwangciselwe ukwenza uvavanyo lwemanometry ye-antroduodenal.Emva kokufakwa kwe-catheter, iqela lijonge ukuhamba komntwana ngamnye ngexesha lokuzila ukutya ubuncinane iiyure ezintathu.Abantwana ke bafumana idosi enyeamoxicillin-clavulanatengokungenanjongo, nokuba yiyure enye phambi kokutya okanye iyure enye emva kokutya kwaye emva koko ube nokujongwa kokuhamba ngeyure enye elandelayo.

Uphononongo lwabonisa ukubaamoxicillin-clavulanatekwabangela amaqela okuxhuzula okwandisiweyo ngaphakathi kwamathumbu amancinci, afana nalawo abonwa ngexesha le-duodenal isigaba III senkqubo ye-interdigestive motility.Le mpendulo yenzeke kuninzi lwabathathi-nxaxheba kwimizuzu yokuqala ye-10-20 kwaye yabonakala kakhulu xa i-amoxicillin-clavulanate yanikwa ngaphambi kokutya.

"Ukunyanzeliswa kwe-preprandial duodenal phase III kunokukhawuleza ukuhamba kwamathumbu amancinci, kuthintele i-gut microbiome kwaye kudlale indima ekuthinteleni ukuphuhliswa kwebhaktheriya encinci," kusho uDkt Di Lorenzo.

UGqr. Di Lorenzo uthi i-amoxicillin-clavulanate inokusebenza kakhulu kwizigulana ezinotshintsho lwesigaba sesi-III se-duodenal, iimpawu ezingapheliyo ze-intestinal pseudo-obstruction kunye nezo zondliwa ngokuthe ngqo kwisisu esincinci kunye ne-gastrojejunal nasojejunal feeding tubes okanye i-jejunostomy yotyando.

Nangona i-amoxicillin-clavulanate ibonakala ichaphazela kakhulu amathumbu amancinci, iindlela esebenza ngazo azicacanga.UGqr. Di Lorenzo ukwatsho ukuba i-downsides enokwenzeka yokusebenzisa i-amoxicillin-clavulanate njenge-agent ye-prokinetic ibandakanya ukungeniswa kokuchasana kwebhaktheriya, ngakumbi kwiibhaktheriya zegram negative ezifana ne-E. coli kunye ne-Klebsiella kunye nokubangela i-Clostridium difficile induced colitis.

Sekunjalo, uthi uphando olongezelelweyo lwezibonelelo zexesha elide ze-amoxicillin-clavulanate kwiimeko zekliniki yesisu lufanelekile."Ukunqongophala kweendlela zonyango ezikhoyo ngoku kunokuthethelela ukusetyenziswa kwe-amoxicillin-clavulanate kwizigulana ezikhethiweyo ezineendlela ezinzima ze-bowel dysmotility encinci apho olunye ungenelelo lungakhange lusebenze," utshilo.