News.pharmnet.com.cn 2021-11-25 China News Network
Ngomhla wama-23 kuNovemba, iChongqing GAOJIN Biotechnology Co., Ltd. (emva koku ebizwa ngokuba yi-“GAOJIN biotechnology”) yesiseko soshishino lwebhayoloji yesizwe yeChongqing high tech Zone yabhengeza ukuba ngokusekwe kwi-isotope ye-boron-10 engekho mitha, iphuhlise ngempumelelo ichiza lokuqala BPA boron amathumba eziyingozi ezifana melanoma, umhlaza wobuchopho kunye glioma, nto leyo yaphathwa BNCT, ezizezi boron neutron ukubamba unyango Ukuya kuthi ga kwimizuzu engama-30 inokunyanga iintlobo zomhlaza ezithile.
I-BNCT yenye yeendlela eziphambili zonyango zomhlaza kwihlabathi.Itshabalalisa iiseli zomhlaza nge-atomic reaction reaction kwiiseli zethumba.Umgaqo wayo wonyango ngulo: qala ngokutofa i-boron engeyotyhefu nengenabungozi equlathe ichiza kwisigulana.Emva kokuba ichiza lingene emzimbeni womntu, lijolise ngokukhawuleza kwaye liqokelele kwiiseli ezithile zomhlaza.Ngeli xesha, imitha ye-neutron enomonakalo omncinci kumzimba womntu isetyenziselwa i-irradiation.Emva kokuba i-neutron ingqubane ne-boron ingena kwiiseli zomhlaza, kuye kuvele “intshukumo yenyukliya” eyomeleleyo, ikhupha imitha ye-ion eyingozi kakhulu.Uluhlu lwe-ray lufutshane kakhulu, olunokuthi lubulale kuphela iiseli zomhlaza ngaphandle kokonakalisa izicubu ezijikelezileyo.Le teknoloji ye-radiotherapy ekujoliswe kuyo ebulala kuphela iiseli zomhlaza ngaphandle kokonakalisa izihlunu eziqhelekileyo ibizwa ngokuba yi-boron neutron capture therapy.
Okwangoku, ichiza le-boron ye-BPA kunye nekhowudi yebhayoloji ye-GAOJIN ye-"gjb01" ilugqibile uphando lwamayeza lwe-API kunye nolungiselelo, kwaye yagqiba inkqubo yokulungiselela isikali sokulinga.Kamva, inokusetyenziswa kumaziko e-R & D e-BNCT izixhobo zonyango lwe-neutron e-China ukwenza uphando olufanelekileyo, uvavanyo kunye nesicelo seklinikhi.Kuyafaneleka ukuqaphela ukuba imveliso yokulinga iyikhonkco eyimfuneko yokuguqulwa kweempumelelo zenzululwazi kunye nezobuchwepheshe zibe yimikhosi evelisayo, kunye nokuphumelela okanye ukungaphumeleli kwe-industrialization of achievements ikakhulu kuxhomekeke kwimpumelelo okanye ukungaphumeleli kwemveliso yokulinga.
NgoMatshi ka-2020, i-steboronine, isixhobo sokuqala se-BNCT sehlabathi kunye neyokuqala yehlabathi ye-boron ichiza, yamkelwa ukuba ithengiswe e-Japan ngenxa yokungachasekiyo kwindawo eqhubela phambili okanye umhlaza wentloko kunye nomhlaza ovela ekuhlaleni.Ukongeza, amakhulu ovavanyo lweklinikhi luye lwenziwa kumathumba engqondo, i-melanoma enobungozi, umhlaza wemiphunga, i-mesothelioma ye-pleural, umhlaza wesibindi, kunye nomhlaza wamabele, kunye nedatha elungileyo yokunyanga ifunyenwe.
UCai Shaohui, usekela-manejala jikelele kunye nenkokeli yeprojekthi ye-GAOJIN biology, uthe isalathiso sisonke se-"gjb01" sihambelana ngokupheleleyo namachiza e-steboronine adweliswe eJapan, kwaye ukusebenza kweendleko kuphezulu.Kulindeleke ukuba isetyenziswe eklinikhi ngo-2023 kwaye kulindeleke ukuba ibe yeyokuqala kuluhlu lwe-BNCT ye-boron ichiza elichasene nomhlaza eTshayina.
UCai Shaohui uthe, "imeko ephucukileyo yonyango lwe-BNCT ayinamathandabuzo.Undoqo liyeza lebhoron.Injongo yebhayoloji ye-Jin ephezulu kukwenza unyango lwaseTshayina lwe-BNCT lufikelele kwinqanaba eliphambili kwihlabathi.Iindleko zonyango zinokulawulwa ngokufanelekileyo malunga ne-100 lamawaka eyuan, ukuze abaguli abanomhlaza bafumane unyango kwaye babe nemali yokunyanga. "
"Unyango lwe-BNCT lunokubizwa ngokuba 'yiperile kwisithsaba' sonyango lomhlaza ngenxa yeendleko eziphantsi, unyango olufutshane (imizuzu engama-30-60 ngexesha ngalinye, unyango olukhawulezayo lunokunyangwa kanye okanye kabini kuphela), izibonakaliso ezibanzi kunye nezantsi. imiphumela."Wang Jian, i-CEO ye-GAOJIN yebhayoloji, wathi eyona nto ibalulekileyo kukujolisa kunye nenkqubo yokulungiselela iziyobisi ze-boron, Inquma ukuba unyango lunokuphatha ngcono kwaye ngokuchanekileyo iintlobo ezininzi zomhlaza.
Ixesha lokuposa: Nov-25-2021