Iintsana kunye nabantwana kwiinyanga ezi-9 ukuya kwi-4 yeminyaka ubudala abane-anemia ye-iron-iron enomsoco ibe nokunyuka okukhulu kwi-hemoglobin concentration kunye ne-ferrous sulfate kune-iron-polysaccharide complexes kwiiveki ze-12, ngokutsho kovavanyo lweklinikhi olupapashwe kwi-JAMA.Enkulu.
I-anemia yokusilela kwe-iron kwiintsana nakubantwana abancinci - edla ngokubangelwa kukusetyenziswa kakhulu kobisi lwenkomo okanye ukuncancisa ixesha elide ngaphandle kokuxhaswa kwentsimbi okufanelekileyo - kuchaphazele abantu abangaphezu kwebhiliyoni e-1 kwihlabathi liphela ngo-2010, i-3% yabo ibineminyaka eyi-1 ukuya kwe-2 ubudala eMelika. .Ngokuqhelekileyo kwenzeka kubantwana abakhula ngokukhawuleza kwaye kunokubangela ukucaphuka, i-malaise, i-pica, kunye ne-neurodevelopmental disorders yexesha elifutshane kunye nexesha elide.
I-Ferrous sulfate, ityuwa yentsimbi, yonyango oluqhelekileyo lwe-anemia ye-iron-iron-deficiency.Nangona kunjalo, i-iron-polysaccharide complex equkethe i-iron ferric (NovaFerrum, iGensavis Pharmaceuticals) ingasetyenziselwa njengenye indlela kuba inokuphucula ukunyamezela kunye nokunambitha.
"Ukungaphumeleli kwonyango kuqhelekileyo ngenxa yokunganyangeki kweyeza, imiphumo emibi ehambelana nokugqithisa, kunye nokungabikho kwezikhokelo zolawulo olusekelwe kubungqina," kusho uJacquelyn M. Powers, MD, MS, School of Medicine, uProfesa oNcedisayo waseBaylor wePediatrics kunye neHematology. / I-Oncology, kunye noogxa babhala."Zimbalwa iimvavanyo zeklinikhi ezingakhethiyo ezichaza ukhetho lwe-iron formulation, irejimeni yedosi, kunye nobude bonyango, kungakhathaliseki ukuba i-etiology esisiseko, ubudala, okanye isini sabantu abachaphazelekayo."
Amandla kunye noogxa bavavanya i-iron-polysaccharide complexes kwiintsana ezingama-80 kunye nabantwana kwi-9 ukuya kwiinyanga ezingama-48 (ubudala obuphakathi, iinyanga ezingama-22; i-55% yamadoda; i-61% emhlophe yaseSpanishi) kunye ne-anemia yezondlo zentsimbi.i-ferrous sulfateukwandisa uxinzelelo lwe-hemoglobin.
Phakathi kukaSeptemba 2013 kunye noNovemba 2015, abaphandi babela abantwana ukuba bafumane i-3 mg / kg yentsimbi ye-elemental kanye ngosuku njenge-ferrous sulfate drops (n = 40) okanye i-iron-polysaccharide complex drops (n = 40) = 40) kwiiveki ze-12 .
Abazali okanye abanonophelo bayalelwa ukuba basebenzise idosi yemihla ngemihla ngexesha lokulala, ukuphepha ukuxuba umthamo kunye nakuphi na ukutya okanye isiselo, kunye nokuphepha ubisi ngeyure eyi-1 emva kokulawulwa kweyeza lokufunda. ubuninzi be-600ml ngosuku.
Utshintsho kwi-hemoglobin kwiiveki ze-12 zisebenza njengeyona nto iphambili ekupheleni.Iziphelo zesibini zibandakanya isisombululo esipheleleyo se-anemia ye-iron, utshintsho kumanqanaba e-serum ferritin kunye ne-iron-binding capacity, kunye nemiphumo emibi.
Abathathi-nxaxheba abangamashumi amahlanu anesithoba bagqiba uvavanyo, i-28 kwiqela le-ferrous sulfate kunye ne-31 kwiqela eliyinkimbinkimbi ye-iron-polysaccharide.
Ukususela kwisiseko ukuya kwiveki ye-12, i-hemoglobin ithetha i-7.9 g / dL ukuya kwi-11.9 g / dL kwiqela le-ferrous sulfate kunye ne-7.7 g / dL ukuya kwi-11.1 g / dL kwiqela eliyinkimbinkimbi ye-iron-polysaccharide, umehluko omkhulu we-1 g / dL (95% CI, 0.4-1.6; P <.001) kunye ne-ferrous sulfate.
Xa kuthelekiswa neqela le-iron polysaccharide, iintsana kunye nabantwana kwiqela le-ferrous sulfate banamazinga aphezulu okuxolelwa okupheleleyo kwe-anemia ye-iron (29% vs 6%; P = .04) .Inqanaba le-serum ferritin lenyuka ukusuka kwi-3 ng / mL ukuya I-15.6 ng / mL kwiqela le-ferrous sulfate kunye ne-2 ng / mL ukuya kwi-7.5 ng / mL kwiqela le-iron-polysaccharide eliyinkimbinkimbi, kunye nokwahlukana okukhulu kwe-10.2 ng / mL (95 ng / mL).% CI, 6.2-14.1;P <.001) nge-ferrous sulfate.
Umyinge we-iron-binding umthamo wehla ukusuka kwi-501 µg/dL ukuya kwi-389 µg/dL, ngelixa i-ferrous sulfate yehla ukusuka kwi-506 µg/dL ukuya kwi-417 µg/dL, kunye ne-iron-polysaccharide complex -50 µg/dCL (95%). , -86 ukuya -14; P <.001) kunye ne-ferrous sulfate.
I-diarrhea yayixhaphake kakhulu nge-iron-polysaccharide complexes kune-ferrous sulfate (58% vs 35%; P = .04).
Abaphandi baqaphela ukuba i-50 ekhulwini yabazali kunye nabanonophelo babika ubunzima bokulawula i-iron-polysaccharide complex, xa kuthelekiswa neepesenti ze-65 zeqela le-ferrous sulfate.
Ukulinganiselwa kolu phando kwakubandakanya ukuba kuqhutywe kwisibhedlele sabantwana benqanaba eliphezulu kwaye babe nenani elilinganayo lezigulane eziphantsi kunye nezincinci ezine-anemia enzima, malunga ne-23% efuna utofelo-gazi ngaphambi kokubhaliswa.
"Ezi ziphumo kufuneka zincede ukuqhubela phambili izilingo zeklinikhi zokuvavanya idosi ephantsi okanye engaphantsi rhoqo yentsimbi yomlomo," Amandla kunye noogxa babhala." Iziphumo ezilindelekileyo zingabandakanya ukuphuculwa kokuthotyelwa kwesigulane kunye nokunyuswa kwentsimbi, okukhokelela ekuphenduleni okulungileyo kwi-hematologic.-UChuck Gormley
Ukubhengeza: IGensavis Pharmaceuticals ixhase ngemali olu phononongo. Abaphandi baxela ukuba akukho ludizo lwemali olufanelekileyo.
Ixesha lokuposa: Mar-21-2022