EKhanada: Abafazi abakhulelweyo, abanembali yokwaliwa yipenicillin bakwazi ukugqibezela ngempumelelo ngomlomo othe ngqoamoxicillinimiceli mngeni ngaphandle kwesidingo sokuvavanywa kwesikhumba kwangaphambili, ithi inqaku elipapashwe kwiIjenali ye-Allergy kunye ne-Clinical Immunology: Uziqhelanisa.
Kwiintlobo ngeentlobo zezigulana, ukuchazwa kwe-penicillin allergy de-labeling kufunyenwe kukhuselekile kwaye kuyimpumelelo kubantu abasengozini ephantsi.Uvavanyo lubonisa ukuba ngaphezu kwe-90% yabantu abalalisi kwasekuqaleni.Ngaphandle kwento yokuba ukukhulelwa akuwonyusi umngcipheko we-penicillin allergy, abafazi abakhulelweyo bahlala beshiywa kuphando oluninzi.Olu phononongo lwenziwe nguRaymond Mak kunye neqela kukhuseleko lweAmoxicillinkwabasetyhini abakhulelweyo.
Phakathi kukaJulayi ka-2019 kunye noSeptemba 2021, oogqirha kwisibhedlele sase-BC Women's Hospital kunye neZiko lezeMpilo banike imiceli mngeni yomlomo ngqo kubasetyhini abakhulelweyo abangama-207 abaphakathi kweminyaka engama-28 kunye neveki ezingama-36 zokukhulelwa.Ngenxa yokuba la manenekazi onke ayenamanqaku e-PEN-FAST ka-0, isixhobo se-penicillin esiqinisekisiweyo sokwaliwa nokwaliwa kwesixhobo sonyango esilindele ukuba nokwenzeka kovavanyo oluqinisekileyo lwesikhumba, bonke bagwetywe besemngciphekweni ophantsi kakhulu.La manenekazi babonwa iyure enye emva kokuthatha 500 mg ofamoxicillinngomlomo.Oogqirha bathatha iimpawu zabo ezibalulekileyo ekuqaleni, kwimizuzu eyi-15 kamva, kunye neyure emva koko.Izigulane ezingabonisi zimpawu zeempendulo ze-IgE-mediated zaye zagxothwa ngemiyalelo yokuqhagamshelana neklinikhi ukuba zinenkxalabo malunga nokusabela okulibazisekayo.
Iziphumo eziphambili zolu phononongo zibe ngolu hlobo lulandelayo:
1. Kwakungekho kwangoko okanye kulibaziseka i-hypersensitivity kwi-203 yaba bantu.
2. Izigulane ezine ezisele (1.93%) zineengqungquthela ze-maculopapular ezinobungozi, eziphathwe nge-betamethasone valerate i-0.1% ye-ointment kunye ne-antihistamines.
3. Izinga lokuphendula le-1.93% lithelekiseka nereyithi exelwe ngaphambili ye-1.99% kubantu abadala abangakhulelwanga kunye nezinga le-2.5% kubantu abakhulelweyo.
4. Kwakungekho bantu bafuna i-epinephrine okanye i-anaphylaxis, kwaye akukho namnye owangeniswa esibhedlele ngenxa yovavanyo.
Ukuqukumbela, ngokutsho kwabaphandi, ukunciphisa imfuno yovavanyo lwesikhumba sepenicillin kuya kunciphisa iindleko ze-reagent, ixesha leklinikhi, kunye nesidingo sokutyelela i-subspecialist, konke oko kuya kuphucula ukhathalelo lwesigulane ngexesha lomsebenzi kunye nokunikezelwa.Ukufumana ubungqina obunamandla ngakumbi, uphando olukhulu ngakumbi luyafuneka.
ref:Mak, R., Zhang, BY, Paquette, V., Erdle, SC, Van Schalkwyk, JE, Wong, T., Watt, M., & Elwood, C. (2022).UKhuseleko loMceli mngeni othe ngqo woMlomo kwi-Amoxicillin kwiZigulana ezikhulelweyo kwiSibhedlele saseKhanada saseKhanada.KwiJenali ye-Allergy kunye ne-Clinical Immunology: Uziqhelanisa.Elsevier BV.
Ixesha lokuposa: Apr-25-2022