Uphononongo kwiimpuku lucebisa ukuba ukuthathaivithamin Cinokunceda ukuchasana nokumoshakala kwezihlunu, isiphumo esiqhelekileyo seyeza lechemotherapy idoxorubicin.Nangona izifundo zeklinikhi ziyafuneka ukumisela ukhuseleko kunye nokusebenza ngokufanelekileyo kokuthatha ivithamin C ngexesha lonyango lwe-doxorubicin, iziphumo zibonisa ukuba ivithamin C inokumela ithuba elithembisayo lokunciphisa ezinye zeziphumo ebezingalindelekanga zechiza.
Iziphumo zethu zibonisa ukuba ivithamin C yonyango enokubakho yokunceda ukunyanga isifo sezihlunu zeperipheral kulandela unyango lwe-doxorubicin, ngaloo ndlela iphucula amandla okusebenza kunye nomgangatho wobomi kunye nokunciphisa ukufa.
U-Antonio Viana do Nascimento Filho, M.Sc., Universidad Nova de Julio (UNINOVE), eBrazil, umbhali wokuqala wokufunda, uya kubonisa iziphumo kwintlanganiso yonyaka ye-American Physiological Society ngexesha le-2022 Experimental Biology (EB) intlanganiso e Philadelphia, April 2-5.
I-Doxorubicin liyeza le-anthracycline chemotherapy elihlala lisetyenziswa kunye namanye amachiza echemotherapy ukunyanga umhlaza wamabele, umhlaza wesinyi, i-lymphoma, i-leukemia, kunye nezinye iintlobo zomhlaza.Nangona ilichiza elisebenzayo lokulwa nomhlaza, i-doxorubicin inokubangela iingxaki ezinzulu zentliziyo kunye nokonakala kwezihlunu, ezineziphumo ezihlala ixesha elide kumandla omzimba amaxhoba kunye nomgangatho wobomi.
Ezi ziphumo zecala zicingelwa ukuba zibangelwa ukuveliswa ngokugqithiseleyo kwezinto ezisebenza nge-oxygen okanye "i-radicals yamahhala" emzimbeni.Ivithamin Ci-antioxidant yendalo enokunceda ukunciphisa uxinzelelo lwe-oxidative, uhlobo lomonakalo obangelwa yi-radicals yamahhala.
Kuphononongo lwangaphambili kunye neYunivesithi yaseManitoba eCanada, iqela lafumanisa ukuba i-vitamin C iphucule iimpawu zempilo yentliziyo kunye nokusinda kwiigundane ezinikwe i-doxorubicin, ngokuyinhloko ngokunciphisa uxinzelelo lwe-oxidative kunye nokuvuvukala.Kuphononongo olutsha, bavavanye ukuba ingaba ivithamin C inokunceda na ukuthintela iziphumo ezibi ze-doxorubicin kwisihlunu samathambo.
Abaphandi baqhathanisa ubunzima be-skeletal muscle kunye namanqaku oxinzelelo lwe-oxidative kumaqela amane eegundane, nganye kwi-8 kwizilwanyana ze-10.Elinye iqela labathatha omabiniivithamin Ckunye ne-doxorubicin, iqela lesibini lathatha kuphela i-vitamin C, iqela lesithathu lathatha kuphela i-doxorubicin, kwaye iqela lesine alizange lithathe nokuba.Iimpuku ezinikwe ivithamin C kunye ne-doxorubicin zibonise ubungqina bokuncitshiswa koxinzelelo lwe-oxidative kunye nobunzima bezihlunu obungcono xa kuthelekiswa neempuku ezinikwe i-doxorubicin kodwa ingeyiyo ivithamin C.
Kuyavuyisa ukuba unyango lwe-prophylactic kunye nonyango oluhambelana ne-vitamin C olunikwe iveki enye ngaphambi kwe-doxorubicin kunye neeveki ezimbini emva kokuba i-doxorubicin yanele ukunciphisa iziphumo ebezingalindelekanga zeli chiza kwi-skeletal muscle, ngaloo ndlela kuncitshiswe isiphumo esihle esikhulu kwisihlunu samathambo.Ukufundisisa impilo yezilwanyana,” utsho uNascimento Filho.”Umsebenzi wethu ubonisa ukuba unyango lwevithamin C lunciphisa ukuphulukana nezihlunu kwaye luphucula iimpawu ezininzi zokungalingani kweradical yasimahla kwiimpuku ezifumene idoxorubicin.”
Izazinzulu ziqaphele ukuba uphando olongezelelweyo, kubandakanywa nolingo lweklinikhi olungahleliwe, luyafuneka ukuze kuqinisekiswe ukuba ukuthatha i-vitamin C ngexesha lonyango lwe-doxorubicin luncedo kwizigulane zabantu kunye nokumisela idosi efanelekileyo kunye nexesha.Uphando lwangaphambili lubonisa ukuba i-vitamin C inokuphazamisa imiphumo ye-chemotherapy drug, ngoko izigulane azicetyiswa ukuba zithathe izongezo ze-vitamin C ngexesha lonyango lomhlaza ngaphandle kokuba ziyalelwe ngugqirha wazo.
Ixesha lokuposa: Apr-26-2022