I-antibiotic ejwayelekile,i-amoxicillin-clavulanate, ingase ithuthukise ukusebenza kwamathumbu amancane ezinganeni ezinenkinga yokuphazamiseka kokuhamba, ngokocwaningo oluvela kumagazini onyathelisiwe kaJuni we-Journal of Pediatric Gastroenterology and Nutrition evela ku-Nationwide Children's Hospital.
I-Amoxicillan-clavulanate, eyaziwa nangokuthi i-Augmentin, inqunyelwe ukwelapha noma ukuvimbela izifo ezibangelwa amagciwane.Kodwa-ke, kuphinde kwabikwa ukuthi kwandisa ukuhamba kwamathumbu amancane kubantu abanempilo futhi iye yasetshenziselwa ukwelapha ukwanda kwamagciwane ezigulini ezinesifo sohudo esingamahlalakhona.
Izimpawu zamathumbu aphezulu anjengokucanuzela kwenhliziyo, ukuhlanza, ubuhlungu besisu, ukusutha kusenesikhathi kanye nokuqunjelwa kwesisu zivamile ezinganeni.Naphezu kwentuthuko yobuchwepheshe bokuxilonga ukuphazamiseka kwe-motility, kuyaqhubeka nokuntuleka kwemithi etholakalayo yokwelapha ukusebenza kwe-motor motor ye-gastrointestinal.
"Kunesidingo esibalulekile semithi emisha yokwelapha izimpawu eziphezulu zesisu ezinganeni," kusho uCarlo Di Lorenzo, MD, isikhulu se-Gastroenterology, Hepatology and Nutrition at Nationalwide Children's Hospital kanye nomunye wabalobi bocwaningo."Izidakamizwa ezisetshenziswa njengamanje zivame ukutholakala kuphela ngesisekelo esikhawulelwe, zinemiphumela emibi kakhulu noma zingasebenzi ngokwanele emathunjini amancane namakhulu."
Ukuhlola ukuthi i-amoxicillin-clavulanate ingase isebenze njengendlela entsha yokwelapha ukusebenza kwemigudu yomzila wesisu ongenhla, abaphenyi e-Nationwide Children's bahlola iziguli ezingu-20 okwakuhlelelwe ukuthi zihlolwe i-antroduodenal manometry.Ngemva kokufakwa kwe-catheter, ithimba laqapha ukuhamba kwengane ngayinye ngesikhathi sokuzila ukudla okungenani amahora amathathu.Izingane zabe zithole umthamo owodwai-amoxicillin-clavulanateNgokuvamile, ihora elilodwa ngaphambi kokudla noma ihora elilodwa ngemva kokudla bese igadwa i-motility ihora elilodwa elilandelayo.
Ucwaningo lwabonisa lokhoi-amoxicillin-clavulanatekwaqala amaqembu okufinyela okusakazekile ngaphakathi kwamathumbu amancane, afana nalawo abonwa ngesikhathi sesigaba III se-duodenal yenqubo ye-interdigestive motility.Le mpendulo yenzeka kwabaningi babahlanganyeli bocwaningo phakathi nemizuzu yokuqala eyi-10-20 futhi yabonakala kakhulu lapho i-amoxicillin-clavulanate inikezwa ngaphambi kokudla.
"Ukwenza i-preprandial duodenal phase III kungase kusheshise ukuhamba kwamathumbu amancane, kuthonye i-gut microbiome futhi kube nendima ekuvimbeleni ukuthuthukiswa kokukhula kwebhaktheriya emathunjini amancane," kusho uDkt. Di Lorenzo.
UDkt. Di Lorenzo uthi i-amoxicillin-clavulanate ingase isebenze kakhulu ezigulini ezinezinguquko zesigaba III se-duodenal, izimpawu ezingapheli zokuvinjelwa kwamathumbu emathunjini kanye nalezo ezincelwa ngqo ethunjini elincane ngamashubhu okuphakela i-gastrojejunal nasojejunal noma i-jejunostomy yokuhlinzwa.
Yize i-amoxicillin-clavulanate ibonakala ithinta kakhulu ithumbu elincane, izindlela esebenza ngazo azicacile.UDkt. Di Lorenzo uphinde athi ukwehla okungaba khona kokusebenzisa i-amoxicillin-clavulanate njenge-ejenti ye-prokinetic kuhlanganisa ukungeniswa kokumelana namagciwane, ikakhulukazi asuka kumagciwane e-gram negative afana no-E. coli ne-Klebsiella futhi abangele i-Clostridium difficile induced colitis.
Noma kunjalo, uthi uphenyo olwengeziwe lwezinzuzo zesikhathi eside ze-amoxicillin-clavulanate ezimweni zomtholampilo wesisu lubalulekile."Ukushoda kwezindlela zokwelapha ezitholakalayo njengamanje kungase kuthethelele ukusetshenziswa kwe-amoxicillin-clavulanate ezigulini ezikhethiwe ezinezinhlobo ezinzima ze-dysmotility yamathumbu amancane lapho okunye ukungenelela kungazange kusebenze," esho.
Isikhathi sokuthumela: May-11-2022