News.pharmnet.com.cn 2021-11-25 China News Network
Ngomhla zingama-23 kuNovemba, iChongqing GAOJIN Biotechnology Co., Ltd. (ngemuva kwalokhu ebizwa ngokuthi “GAOJIN biotechnology”) yesizinda semboni yebhayoloji kazwelonke yaseChongqing high tech Zone yamemezela ukuthi ngokususelwa ku-isotope ye-boron-10 engeyona imisebe, isithuthukise ngempumelelo Umuthi wokuqala we-BPA we-boron wezimila eziyingozi njenge-melanoma, umdlavuza wobuchopho kanye ne-glioma, owalashwa yi-BNCT, okungukuthi i-boron neutron capture therapy Kuze kube yimizuzu engama-30 ingakwazi ukwelapha izinhlobo ezithile zomdlavuza.
I-BNCT ingenye yezindlela ezithuthuke kakhulu zokwelapha umdlavuza emhlabeni.Ibhubhisa amangqamuzana omdlavuza ngokusabela kwe-athomu yenuzi kumaseli wesimila.Umgomo wayo wokwelapha uthi: qala ngokujova i-boron engenabuthi nengenabungozi esigulini.Ngemuva kokuthi umuthi usungene emzimbeni womuntu, uqondisa ngokushesha futhi unqwabelane kumaseli athile omdlavuza.Ngalesi sikhathi, umsebe we-neutron onomonakalo omncane emzimbeni womuntu usetshenziselwa ukukhipha imisebe.Ngemuva kokuthi i-neutron ishayisane ne-boron ingena kumangqamuzana omdlavuza, kukhiqizwa "ukusabela kwenyukliya" okuqinile, kukhiphe umsebe we-ion osindayo obulala kakhulu.Uhla lomsebe lufushane kakhulu, olungabulala amangqamuzana omdlavuza kuphela ngaphandle kokulimaza izicubu ezizungezile.Lobu buchwepheshe obukhethiwe obuqondiswe nge-radiotherapy obubulala kuphela amangqamuzana omdlavuza ngaphandle kokulimaza izicubu ezivamile bubizwa ngokuthi i-boron neutron capture therapy.
Njengamanje, umuthi we-BPA boron onekhodi yebhayoloji ye-GAOJIN ethi “gjb01″ uqedele ucwaningo lwezemithi lwe-API nokulungiselela, futhi uqedele ukuqinisekiswa kwenqubo yokulungiselela isikali sokuhlola.Kamuva, ingasetshenziswa ezikhungweni ze-R & D ze-BNCT neutron therapy amadivayisi e-China ukwenza ucwaningo olufanele, ukuhlolwa kanye nokusetshenziswa komtholampilo.Kuyaphawuleka ukuthi ukukhiqizwa kokuhlola kuyisixhumanisi esidingekayo sokuguqulwa kwezimpumelelo zesayensi nezobuchwepheshe zibe amandla okukhiqiza, futhi impumelelo noma ukwehluleka kokuthuthukiswa kwezimboni zezimpumelelo ikakhulukazi kuncike empumelelweni noma ekuhlulekeni kokukhiqizwa kokuhlola.
NgoMashi 2020, i-steboronine, idivayisi yokuqala emhlabeni ye-BNCT kanye nomuthi wokuqala emhlabeni we-boron, yagunyazwa ukuthi imakethwe e-Japan ngomdlavuza wekhanda nowentamo ongaxazululeki endaweni yangakini ophindelelayo.Ngaphezu kwalokho, kuye kwenziwa izivivinyo zomtholampilo ezingamakhulu ebuchosheni, i-melanoma eyingozi, umdlavuza wamaphaphu, i-pleural mesothelioma, umdlavuza wesibindi, nomdlavuza wamabele, kanye nedatha yokwelapha enhle itholakele.
U-Cai Shaohui, isekela lomphathi jikelele kanye nomholi wephrojekthi ye-GAOJIN biology, uthe inkomba iyonke ye-“gjb01″ ihambisana ngokuphelele nezidakamizwa ze-steboronine ezisohlwini lwase-Japan, futhi ukusebenza kwezindleko kuphezulu.Kulindeleke ukuthi isetshenziswe emtholampilo ngo-2023 futhi kulindeleke ukuthi ibe isidakamizwa sokuqala esisohlwini se-BNCT anti-cancer boron eChina.
UCai Shaohui uthe, "isimo esithuthukile sokwelashwa kwe-BNCT akungabazeki.Umnyombo umuthi we-boron.Umgomo webhayoloji ye-Jin ephezulu ukwenza ukwelashwa kwe-BNCT yaseChina kufinyelele ezingeni elihamba phambili emhlabeni.Izindleko zokwelashwa zingalawulwa ngempumelelo cishe ngama-yuan ayizinkulungwane eziyi-100, ukuze iziguli ezinomdlavuza zithole ukwelashwa futhi zibe nemali yokwelapha.”
"Ukwelashwa kwe-BNCT kungabizwa ngokuthi 'iparele emqheleni' wokwelashwa komdlavuza ngenxa yezindleko zakho eziphansi, ukwelashwa okufushane (imizuzu engama-30-60 isikhathi ngasinye, ukwelashwa okushesha kakhulu kungelapheka kanye noma kabili), izinkomba ezibanzi futhi eziphansi. okuqhamuka uma udla imishanguzo."U-Wang Jian, oyi-CEO ye-GAOJIN biology, uthe ukhiye obaluleke kakhulu inqubo yokukhomba nokulungiswa kwezidakamizwa ze-boron, Inquma ukuthi ukwelapha kungakwazi yini ukwelapha kangcono futhi ngokunembile izinhlobo eziningi zomdlavuza.
Isikhathi sokuthumela: Nov-25-2021