Izinsana kanye nezingane ezinezinyanga ezingu-9 kuya eminyakeni engu-4 ubudala ezine-anemia yokuntuleka kwensimbi enomsoco zibe nokwanda okukhulu kwe-hemoglobin ene-ferrous sulfate kunezinkimbinkimbi ze-iron-polysaccharide emavikini angu-12, ngokusho kocwaningo lomtholampilo olungahleliwe olwanyatheliswa ku-JAMA.Okukhulu.
I-anemia yokuntuleka kwe-iron ezinsaneni nasezinganeni ezincane - okuvame ukubangelwa ukusetshenziswa ngokweqile kobisi lwenkomo noma ukuncelisa ibele isikhathi eside ngaphandle kokufakwa okusansimbi okufanele - kuthinte abantu abangaphezu kwebhiliyoni elilodwa emhlabeni jikelele ngo-2010, u-3% wabo owayeneminyaka engu-1 kuya kwemibili ubudala eMelika. .Ngokuvamile ukwenzeka ezinganeni ezikhula ngokushesha futhi kungabangela ukucasuka, ukungezwani komzimba, i-pica, kanye neziyaluyalu ze-neurodevelopmental zesikhathi esifushane nezesikhathi eside.
I-ferrous sulfate, usawoti wensimbi, ukwelapha okujwayelekile kwe-anemia yokuntuleka kwensimbi okunomsoco.Nokho, i-iron-polysaccharide complex equkethe i-ferric iron (NovaFerrum, Gensavis Pharmaceuticals) ingasetshenziswa njengenye indlela ngoba ingase ithuthukise ukubekezelelana nokunambitha.
"Ukwehluleka kokwelashwa kuvamile ngenxa yokungalandelwa kwemithi, imiphumela emibi ehambisana nokusetshenziswa ngokweqile, nokuntuleka kweziqondiso zokuphatha ezisekelwe ebufakazini," kusho uJacquelyn M. Powers, MD, MS, School of Medicine, uProfessor Assistant Baylor wePediatrics and Hematology. /Oncology, kanye nozakwabo babhala.”Zimbalwa izivivinyo zomtholampilo ezingahleliwe ezazisa ukukhethwa kokwakhiwa kwensimbi, uhlobo lwemithamo, kanye nobude besikhathi sokwelashwa, kungakhathaliseki ukuthi i-etiology eyisisekelo, ubudala, noma ubulili babantu abathintekile.
Amandla kanye nozakwethu bahlola i-iron-polysaccharide complexes ezinganeni ezingu-80 nezingane ezineminyaka engu-9 kuya kwezingu-48 (iminyaka ephakathi, izinyanga ezingu-22; 55% wesilisa; 61% iSpanishi emhlophe) ene-anemia yokushoda kwensimbi okunomsoco Ingabe iphumelela kakhului-ferrous sulfateukwandisa ukuhlushwa kwe-hemoglobin.
Phakathi kukaSepthemba 2013 noNovemba 2015, abacwaningi babela izingane ngokungahleliwe ukuthi zithole i-3 mg/kg yensimbi eyisisekelo kanye ngosuku njengamaconsi e-ferrous sulfate (n = 40) noma amaconsi e-iron-polysaccharide complex (n = 40) = 40) amaviki angu-12. .
Abazali noma abanakekeli bayalwa ukuba basebenzise umthamo wansuku zonke ngesikhathi sokulala, ukugwema ukuxuba umthamo nanoma yikuphi ukudla noma isiphuzo, futhi bagweme ubisi ihora eli-1 ngemva kokuphathwa komuthi wocwaningo. umthamo omkhulu - 600 ml ngosuku.
Ushintsho ku-hemoglobin emasontweni angu-12 lwalusebenza njengesiphetho esiyinhloko.Iziphetho zesibili zihlanganisa ukuxazulula okuphelele kwe-anemia yokuntuleka kwensimbi, izinguquko kumazinga e-serum ferritin kanye namandla okubopha insimbi okuphelele, kanye nemiphumela emibi.
Abahlanganyeli abangamashumi amahlanu nesishiyagalolunye baphothule lolu cwaningo, abangu-28 beqembu le-ferrous sulfate kanye nabangu-31 beqembu eliyinkimbinkimbi ye-iron-polysaccharide.
Kusukela ekuqaleni kuya evikini le-12, i-hemoglobin emaphakathi inyuke isuka ku-7.9 g/dL yaya ku-11.9 g/dL eqenjini le-ferrous sulfate futhi isuka ku-7.7 g/dL yaya ku-11.1 g/dL eqenjini eliyinkimbinkimbi ye-iron-polysaccharide, umehluko omkhulu we-1 g / dL (95% CI, 0.4-1.6; P <.001) ene-ferrous sulfate.
Uma kuqhathaniswa neqembu le-iron polysaccharide, izinsana kanye nezingane eziseqenjini le-ferrous sulfate babe namazinga aphezulu okukhululwa okuphelele kwe-anemia yokuntuleka kwensimbi (29% vs 6%; P = .04).Izinga le-serum ferritin elimaphakathi lenyuke lisuka ku-3 ng/mL laya I-15.6 ng/mL eqenjini le-ferrous sulfate futhi isuka ku-2 ng/mL iye ku-7.5 ng/mL eqenjini eliyinkimbinkimbi ye-iron-polysaccharide, elinomehluko omkhulu we-10.2 ng/mL (95 ng/mL).% CI, 6.2-14.1;P <.001) ene-ferrous sulfate.
Ingqikithi yomthamo wokubopha insimbi yehla isuka ku-501 µg/dL yaya ku-389 µg/dL, kuyilapho i-ferrous sulfate yehla isuka ku-506 µg/dL yaya ku-417 µg/dL, kanye ne-iron-polysaccharide complex yaba -50 µg/dC (95% dC). , -86 kuya ku-14; P <.001) kanye ne-ferrous sulfate.
Uhudo lwaluvame kakhulu nge-iron-polysaccharide complexes kune-ferrous sulfate (58% vs 35%; P = .04).
Abacwaningi baphawula ukuthi amaphesenti angu-50 abazali nabanakekeli babike ubunzima bokuphatha i-iron-polysaccharide complex, uma kuqhathaniswa namaphesenti angu-65 weqembu le-ferrous sulfate.
Imikhawulo yalolu cwaningo yayihlanganisa nokuthi lwenziwa esibhedlela sezingane ezinakekelwa imfundo ephakeme futhi inenani elilinganiselwe leziguli ezihola kancane nezimbalwa ezine-anemia enzima, cishe amaphesenti angu-23 azo ayedinga ukumpontshelwa igazi ngaphambi kokubhaliswa.
"Le miphumela kufanele isize ekuqhubekiseni ezinye izivivinyo zomtholampilo zokuhlola imithamo ephansi noma engaphansi evamile yensimbi yomlomo," u-Powers nozakwabo babhala." Imiphumela elindelekile ingase ihlanganise ukuthobela kwesiguli okuthuthukisiwe kanye nokumuncwa kwensimbi okuthuthukisiwe, okuholela ekuphenduleni okuhle kwe-hematological."– Chuck Gormley
Ukudalula: I-Gensavis Pharmaceuticals ixhase lolu cwaningo ngezimali.Abacwaningi babika akukho ukudalulwa kwezimali okufanele.
Isikhathi sokuthumela: Mar-21-2022