ECanada: Abesifazane abakhulelwe, abanomlando wokungezwani ne-penicillin bakwazi ukukuqeda ngempumelelo ngomlomoi-amoxicillinizinselele ngaphandle kwesidingo sokuhlolwa kwesikhumba kwangaphambili, kusho isihloko esishicilelwe kuI-Journal of Allergy and Clinical Immunology: In Practice.
Emiphakathini eyahlukene yeziguli, i-penicillin yokungezwani komzimba ne-de-labeling itholakale iphephile futhi iyimpumelelo kubantu abasengozini encane.Ukuhlolwa kukhombisa ukuthi abantu abangaphezu kuka-90% abaguli kwasekuqaleni.Naphezu kweqiniso lokuthi ukukhulelwa akubandisi ingozi yokungezwani ne-penicillin, abesifazane abakhulelwe bavame ukushiywa ocwaningweni oluningi.Lolu cwaningo lwenziwe nguRaymond Mak nethimba ngokuphepha kweI-Amoxicillinkwabesifazane abakhulelwe.
Phakathi kukaJulayi 2019 noSepthemba 2021, odokotela base-BC Women's Hospital kanye Nesikhungo Sezempilo banikeze izinselelo zomlomo eziqondile kwabesifazane abakhulelwe abangama-207 abaphakathi kweminyaka engama-28 namaviki angama-36 okukhulelwa.Ngenxa yokuthi laba besifazane bonke babenamaphuzu e-PEN-FAST angu-0, ithuluzi lesinqumo sezokwelapha le-penicillin yokungezwani nesiguli elifakazelwe ukuthi lingase libe khona ithuba lokuhlolwa kwesikhumba, bonke babhekwa njengengozi ephansi kakhulu.Laba besifazane babonwa ihora elilodwa ngemuva kokuthatha ama-500 mgi-amoxicillinngomlomo.Odokotela bathatha izimpawu zabo ezibalulekile ekuqaleni, imizuzu eyi-15 kamuva, nehora kamuva.Iziguli ezingabonisi zimpawu zokusabela kwe-IgE-mediated zaxoshwa ngemiyalelo yokuxhumana nomtholampilo uma zikhathazekile ngokusabela okubambezelekile.
Okutholwe okubalulekile kwalolu cwaningo kube kanje:
1. Kwakungekho ukuzwela okusheshayo noma okubambezelekile ku-203 kulaba bantu.
2. Iziguli ezine ezisele (1.93%) zinemihuzuko enobungozi ye-maculopapular, eyalashwa nge-betamethasone valerate 0.1% yamafutha kanye nama-antihistamine.
3. Izinga lokuphendula elingu-1.93% liqhathaniswe nenani elibikwe ngaphambilini elingu-1.99% kubantu abadala abangakhulelwa kanye nenani elingu-2.5% labantu abakhulelwe.
4. Babengekho abantu ababedinga i-epinephrine noma abahlushwa i-anaphylaxis, futhi abekho abangeniswa esibhedlela ngenxa yokuhlolwa.
Sengiphetha, ngokusho kwabacwaningi, ukunciphisa imfuneko yokuhlolwa kwesikhumba se-penicillin kuzonciphisa izindleko ze-reagent, isikhathi somtholampilo, kanye nesidingo sokuvakashela uchwepheshe ongaphansi, konke okuzothuthukisa ukunakekelwa kwesiguli ngesikhathi sokubeletha nokubeletha.Ukuze uthole ubufakazi obuqinile obungeziwe, uphenyo olwengeziwe olukhulu luyadingeka.
ref:Mak, R., Zhang, BY, Paquette, V., Erdle, SC, Van Schalkwyk, JE, Wong, T., Watt, M., & Elwood, C. (2022).Ukuphepha Kwenselelo Eqondile Yomlomo ku-Amoxicillin Ezigulini Ezikhulelwe Esibhedlela Semfundo Ephakeme SaseCanada.KuThe Journal of Allergy and Clinical Immunology: In Practice.Elsevier BV.
Isikhathi sokuthumela: Apr-25-2022